Category: 1968-05-4

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Ethylcellulose microparticles enhance 3,3′-diindolylmethane anti-hypernociceptive action in an animal model of acute inflammatory pain, the main research direction is diindolylmethane ethylcellulose microparticle drug delivery antihypernociceptive inflammatory pain; Microspheres; Von Frey filament; complete Freund’s adjuvant; drug delivery; indole-3-carbinol; inflammatory pain.Name: 3,3′-Diindolylmethane.

Aim The present work aimed at the DIM-loaded microparticles development and anti-hypernociceptive action evaluation. Method The formulations were prepared by O/W solvent emulsion-evaporation method and characterized by particle diameter, content and DIM encapsulation efficiency, drug release profile, thermal behavior and physicochem. state. The anti-hypernociceptive action was evaluated in the animal model of acute inflammatory pain. Result The MPs had a mean diameter in the micrometric range (368 ± 31μm), narrow size distribution, DIM content of 150 mg/g, encapsulation efficiency around 84% and prolonged compound release. Evaluations of the association form of DIM to MPs demonstrated the feasibility of the systems to incorporate DIM and increases its thermal stability. An improvement in the anti-hypernociceptive action of DIM was observed by its microencapsulation, because it was increased and prolonged. Conclusion Therefore, the MPs developed represent a promising formulation for oral administration of the DIM in the treatment of inflammatory pain.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3,3′-Diindolylmethane( cas:1968-05-4 ) is researched.Electric Literature of C17H14N2.Lu, Fengyi; Li, Xiaoming; Chi, Luping; Meng, Linghong; Wang, Bingui published the article 《A new acyclic peroxide from Aspergillus nidulans SD-531, a fungus obtained from deep-sea sediment of cold spring in the South China Sea》 about this compound( cas:1968-05-4 ) in Journal of Oceanology and Limnology. Keywords: Aspergillus acyclic peroxide asperoxide A. Let’s learn more about this compound (cas:1968-05-4).

Abstract: A new acyclic peroxide derivative asperoxide A (1), along with 13 known compounds, namely, microperfuranone (2), 9-hydroxymicroperfuranone (3), gibellulin A (4), lecanoric acid (5), terrequinone A (6), sterigmatocystin (7), isosecosterigmatocystin (8), arugosin C (9), curvularin (10), 3,3-diindolylmethane (11), austinol (12), austin (13), and dehydroaustin (14), were isolated and identified from the culture extract of Aspergillus nidulans SD-531, a fungus obtained from the deep-sea sediment of cold spring in the South China Sea. Their structures were determined based on detailed interpretation of NMR (NMR) spectroscopic and mass spectrometry data anal. All the isolated compounds were evaluated for antimicrobial activities against human and aquatic bacteria as well as plant pathogenic fungi. Compounds 1-28, 10, and 11 exhibited antimicrobial activities against some of the tested strains with min. inhibitory concentration (MIC) values ranging from 2 to 64μg/mL. Compounds 4 and 6 displayed strongest activities among the tested samples and might be used as promising mols. for the development of natural antimicrobial agents.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1968-05-4, is researched, Molecular C17H14N2, about 3,3-diindolylmethane (DIM): a nutritional intervention and its impact on breast density in healthy BRCA carriers. a prospective clinical trial, the main research direction is diindolylmethane nutritional intervention BRCA carrier breast density clin trial.Quality Control of 3,3′-Diindolylmethane.

Women who carry the BRCA mutation are at high lifetime risk of breast cancer, but there is no consensus regarding an effective and safe chemoprevention strategy. A large body of evidence suggests that 3,3-diindolylmethane (DIM), a dimer of indole-3-carbinol found in cruciferous vegetables, can potentially prevent carcinogenesis and tumor development. The primary aim of this prospective single-arm study was to investigate the effect of DIM supplementation on breast d., a recognized predictive factor of breast cancer risk. Participants were 23 healthy female BRCA carriers (median age 47 years; 78% postmenopausal) who were treated with oral DIM 100 mg x 1/day for 1 yr. The amount of fibroglandular tissue (FGT) and background parenchymal enhancement (BPE) on magnetic resonance imaging (MRI) performed before and after the intervention was scored by two independent expert radiologists using the Breast Imaging and Reporting Data System. The results showed a decrease in the average score for FGT amount from 2.8 ± 0.8 at the onset to 2.65 ± 0.84 after 1 yr (P = 0.031), with no significant change in BPE (P = 0.429). A group of DIM-untreated age- and menopausal-status-matched women from the BRCA clinic did not show a significant change in FGT amount (P = 0.33) or BPE (P = 0.814) in a parallel year. Mean estradiol level decreased from 159 to 102 pmol/l (P = 0.01), and mean testosterone level decreased from 0.42 to 0.31 pmol/l (P = 0.007). Side effects were grade 1. In conclusion, 1 yr′s supplementation with DIM 100 mg x 1/day in BRCA carriers was associated with a significant decline in FGT amount on MRI. Larger randomized studies are warranted to corroborate these findings.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 1968-05-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Employing dietary comparators to perform risk assessments for anti-androgens without using animal data.

This study investigated the use of androgen receptor (AR) reporter gene assay data in a non-animal exposure-led risk assessment in which in vitro antiandrogenic activity and exposure data were put into context using a naturally occurring comparator substance with a history of dietary consumption. First, several dietary components were screened to identify which selectively interfered with AR signaling in vitro, using the AR CALUX test. The IC50 values from these dose-response data together with measured or predicted human exposure levels were used to calculate exposure: activity ratios (EARs) for the dietary components and a number of other well-known antiandrogenic substances. Both diindolylmethane (DIM) and resveratrol are specifically acting dietary antiandrogens. The EARs for several antiandrogens were therefore expressed relative to the EAR of DIM, and how this ‘dietary comparator ratio’ (DCR) approach may be used to make safety decisions was assessed using an exposure-led case study for an antiandrogenic botanical ingredient. This highlights a pragmatic approach which allows novel chem. exposures to be put into context against dietary exposures to natural antiandrogenic substances. The DCR approach may have utility for other modes of action where appropriate comparators can be identified.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Anticancer Activity of 3,3′-Diindolylmethane and the Molecular Mechanism Involved in Various Cancer Cell Lines, the main research direction is review DIM anticancer pharmacol.COA of Formula: C17H14N2.

A review. Indole-3-carbinol is a natural compound present in cruciferous plants, which upon digestion, converts into 3,3′-diindolylmethane (DIM) under acidic pH of the stomach. In recent years, various methods have been developed to improve the synthesis of DIM and its analogs because of different pharmacol. activities like anticancer, antimicrobial, anti-inflammatory, etc. Among them, DIMs anticancer activity by modulation of protein expression in cell signaling pathways and other factors has widely studied. This describes the antiproliferative activity of DIMs and its mode of action, which resulted in apoptosis in various cancerous cells. We have performed a literature search on DIMs anticancer activity over the last ten years (2011-2020) and reported in this . Several fascinating DIM attributes against cancer suggest it as a potential candidate for further drug development programs. This will guide the medicinal chemist to find the mechanistic pathways involved in the inhibition of proliferation in cancerous cells by novel DIMs.

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Chlorides – an overview | ScienceDirect Topics

Safety of 3,3′-Diindolylmethane. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about 3,3′-diindolylmethane induces gastric cancer cells death via STIM1 mediated store-operated calcium entry. Author is Ye, Yang; Li, Xue; Wang, Zhihua; Ye, Fen; Xu, Wenrong; Lu, Rongzhu; Shen, Haijun; Miao, Shuhan.

3,3′-Diindolylmethane (DIM), a natural phytochems. isolated from cruciferous vegetables, has been reported to inhibit human gastric cancer cells proliferation and induce cells apoptosis as well as autophagy, but its mechanisms are still unclear. Store-operated calcium entry (SOCE) is a main Ca2+ influx pathway in various of cancers, which is activated by the depletion of endoplasmic reticulum (ER) Ca2+ store. Stromal interaction mol. 1 (STIM1) is the necessary component of SOCE. In this study, we focus on to examine the regulatory mechanism of SOCE on DIM-induced death in gastric cancer. After treating the human BGC-823 and SGC-7901 gastric cancer cells with DIM, cellular proliferation was determined by MTT, apoptosis and autophagy were detected by flow cytometry or Hoechst 33342 staining. The expression levels of related proteins were evaluated by Western blotting. Free cytosolilc Ca2+ level was assessed by fluorescence monitoring under a laser scanning confocal microscope. The data have shown that DIM could significantly inhibit proliferation and induce apoptosis as well as autophagy in two gastric cancer cell lines. After DIM treatment, the STIM1-mediated SOCE was activated by upregulating STIM1 and decreasing ER Ca2+ level. Knockdown STIM1 with siRNA or pharmacol. inhibition of SOCE attenuated DIM induced apoptosis and autophagy by inhibiting p-AMPK mediated ER stress pathway. Our data highlighted that the potential of SOCE as a promising target for treating cancers. Developing effective and selective activators targeting STIM1-mediated SOCE pathway will facilitate better therapeutic sensitivity of phytochems. acting on SOCE in gastric cancer. Moreover, more research should be performed to validate the efficacy of combination chemotherapy of anti-cancer drugs targeting SOCE for clin. application.

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Chlorides – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Nanoformulated bioactive compounds derived from different natural products combat pancreatic cancer cell proliferation, published in 2020, which mentions a compound: 1968-05-4, Name is 3,3′-Diindolylmethane, Molecular C17H14N2, HPLC of Formula: 1968-05-4.

This study was designed to determine the potential effect of nanoencapsulated bioactive compounds from different natural sources on human pancreatic cancer. Pancreatic cancer carries the highest fatality rate among all human cancers because of its high metastatic potential and late presentation at the time of diagnosis. Hence there is a need for improved methods to prevent and treat it. Natural products, such as 3, 3′-diindolylmethane (DIM) and ellagic acid (EA) demonstrated anticancer efficacy against various cancer types. However, DIM is insoluble Hence, using nanotechnol. to encapsulate these compounds in combination with EA might improve their phys. and chem. properties and their delivery to the cancer cells. Human pancreatic cancer cells, namely SUIT2-luciferase transfected, were used to examine the effects of DIM or EA and their nanoformulation in poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) [PLGA-PEG] nanoparticles (NPs) on SUIT2-luciferase cell viability/proliferation over 24 h. Addnl., effects on tumor weight and angiogenesis were determined using the chick chorioallantoic membrane (CAM) tumor implant model. Both DIM and EA PLGA-PEG NPs resulted in rapid suppression of pancreatic cancer cell viability/proliferation within 24 h (P < 0.01), while the non-encapsulated DIM and EA did not show any significant effect on SUIT2 cancer cell viability or cell proliferation (MTT assay). In the CAM pancreatic cancer cell (SUIT2) implant model, results showed a greater suppression of tumor weight (P < 0.01), tumor cell viability, and tumor angiogenesis (P < 0.01) for DIM NPs and EA NPs and their combinations vs. DIM or EA alone. Nanoformulation of DIM and EA resulted in a more effective suppression of pancreatic cancer cell viability, pancreatic tumor weight, implanted cancer cell viability, and tumor angiogenesis as compared with these bioactive compounds alone. From this literature《Nanoformulated bioactive compounds derived from different natural products combat pancreatic cancer cell proliferation》,we know some information about this compound(1968-05-4)HPLC of Formula: 1968-05-4, but this is not all information, there are many literatures related to this compound(1968-05-4).

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1968-05-4, is researched, Molecular C17H14N2, about 3,3′.Diindolylmethane mitigates lipopolysaccharide.induced acute kidney injury in mice by inhibiting NOX.mediated oxidative stress and the apoptosis of renal tubular epithelial cells, the main research direction is acute kidney injury renal tubular epithelial cell apoptosis NOX2; NOX4 DIM oxidative stress.Product Details of 1968-05-4.

3,3′-D iindolylmethane (DIM) is a naturally derived indole compound found in the Brassica family of vegetables. DIM has several beneficial effects, including anti-cancer, anti-inflammatory and anti-angiogenic functions. However, the effects of DIM on acute kidney injury (AKI) stimulated by lipopolysaccharide (LPS) are poorly studied. In this present study, male BALB/c mouse models of AKI were established using i.p. injections of 10 mg/kg LPS. DIM (40 mg/kg) was administered i.p. 24 and 2 h before LPS exposure. The results indicated that DIM significantly mitigated histopathol. changes in the kidneys and improved the levels of blood urea nitrogen and serum creatinine. DIM also suppressed the LPS-induced production of reactive oxygen species and cell apoptosis. Furthermore, DIM treatment significantly decreased the expression of NADPH oxidase 2 (NOX2) and NOX4 in LPS-treated mice. Therefore, DIM may exert its renoprotective actions by inhibiting NOX-mediated oxidative stress and the apoptosis of renal tubular epithelial cells.

There is still a lot of research devoted to this compound(SMILES：C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4)Product Details of 1968-05-4, and with the development of science, more effects of this compound(1968-05-4) can be discovered.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: 1968-05-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about 3,3′-Diindolylmethane Improves Intestinal Permeability Dysfunction in Cultured Human Intestinal Cells and the Model Animal Caenorhabditis elegans.

3,3′-Diindolylmethane (DIM), a digestive metabolite originating from cruciferous vegetables, has dietary potential for the treatment of various human intestinal diseases. Although intestinal permeability dysfunction is closely related to the initiation and progression of human intestinal inflammatory diseases (IBDs), the effect of DIM on intestinal permeability is unclear. We evaluated the effect of DIM on the intestinal permeability of human intestinal cell monolayers and the animal model Caenorhabditis elegans, which were treated with IL-1β and Pseudomonas aeruginosa, resp., to mimic IBD conditions. DIM substantially restored the intestinal permeability of differentiated Caco-2 cells by enhancing the expression of tight junction proteins (including occludin and ZO-1). Compared to the IL-1β single treatment (551.0 ± 49.0 Ω·cm2), DIM (10 μM) significantly increased the transepithelial elec. resistance (TEER) of Caco-2 cell monolayers (919.0 ± 66.4 Ω·cm2, p < 0.001). DIM also ameliorated the impaired intestinal permeability and extended the lifespan of C. elegans fed P. aeruginosa. The mean lifespan of DIM-treated worms (10.8 ± 1.3 days) was higher than that of control-treated worms (9.7 ± 1.1 days, p < 0.01). Thus, DIM is a potential nutraceutical candidate for the treatment of leaky gut syndrome by improving intestinal permeability. From this literature《3,3'-Diindolylmethane Improves Intestinal Permeability Dysfunction in Cultured Human Intestinal Cells and the Model Animal Caenorhabditis elegans》,we know some information about this compound(1968-05-4)HPLC of Formula: 1968-05-4, but this is not all information, there are many literatures related to this compound(1968-05-4).

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocks. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Pharmacophore-inspired discovery of FLT3 inhibitor from kimchi.

Globally consumed kimchi is manufactured through fermenting cruciferous vegetables containing indole glucosinolates (IG). But few reports describe the IG metabolism during the fermentation Here, we show that indole-3-carbinol (I3C), a breakdown product of IG, is transformed during the kimchi fermentation into 3,3-diindolylmethane (DIM) and 2-(indol-3-ylmethyl)-3,3-diindolylmethane (LTr1). LTr1 was found to kill the acute myeloid leukemia (AML) cells with FMS-like tyrosine kinase 3 (FLT3) receptor mutations, by inhibiting the FLT3 phosphorylation and the expression of downstream proteins (STAT5, ERK, and AKT). In the immune-depleted mice xenografted with human MV4-11 cells, LTr1 was demonstrated to reduce the tumor growth and synergize with sorafenib, an anti-AML agent in clinic. The work updates the chem. and biol. knowledge about kimchi, and in particular establishes LTr1 as an FLT3 inhibitor that is effective and synergistic with sorafenib in treating AML.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics