Category: 1968-05-4

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1968-05-4, is researched, SMILESS is C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4, Molecular C17H14N2Journal, Advanced Synthesis & Catalysis called Ruthenium Pincer Complex Catalyzed Selective Synthesis of C-3 Alkylated Indoles and Bisindolylmethanes Directly from Indoles and Alcohols, Author is Biswas, Nandita; Sharma, Rahul; Srimani, Dipankar, the main research direction is alkyl indole selective preparation; bis indolyl methane preparation; indole alc alkylation ruthenium pincer complex catalyst.Computed Properties of C17H14N2.

Herein, we presented Ru-SNS complex that served as a useful catalyst for the synthesis of alkyl-indoles I [R1 = H, 2-Me, 5-OMe, etc.; R2 = H, Me; R3 = Me, Et, Bn, etc.] via C-3 alkylation of 1H-indoles with various aliphatic primary and secondary alcs. including cyclic alcs. as well as benzylic alcs. The selective synthesis of bisindolylmethane derivatives II [R4 = H, Me, Ph, etc.] was also achieved from the same set of indole and alc. just by altering the reaction parameters. Furthermore, the sustainable synthesis of C-3 alkylated indoles directly from 2-(2-nitrophenyl)ethan-1-ol and alcs. catalyzed by a Ru-complex via ‘borrowing hydrogen’ strategy was reported. This protocol provided an atom-economical sustainable route to access structurally important compounds like arundine, vibrindole A and tryptamine based derivatives

If you want to learn more about this compound(3,3′-Diindolylmethane)Computed Properties of C17H14N2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1968-05-4).

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1968-05-4, is researched, Molecular C17H14N2, about Measuring the effects of bacteria and chemicals on the intestinal permeability of Caenorhabditis elegans, the main research direction is Caenorhabditis elegans diindolylmethane bacteria intestinal permeability.Category: chlorides-buliding-blocks.

In living organisms, intestinal hyperpermeability is a serious symptom that leads to many inflammatory bowel diseases (IBDs). Caenorhabditis elegans is a nonmammalian animal model that is widely used as an assay system due to its short lifespan, transparency, cost-effectiveness, and lack of animal ethics issues. In this study, a method was developed to investigate the effects of different bacteria and 3,3′-diindolylmethane (DIM) on the intestinal permeability of C. elegans with a high-throughput image anal. system. The worms were infected with different gut bacteria or cotreated with DIM for 48 h and fed with fluorescein isothiocyanate (FITC)-dextran overnight. Then, the intestinal permeability was examined by comparing the fluorescence images and the fluorescence intensity inside the worm bodies. This method may also have the potential to identify probiotic and pathogenic intestinal bacteria that affect intestinal permeability in the animal model and is effective for examining the effects of harmful or health-promoting chems. on intestinal permeability and intestinal health. However, this protocol also has some considerable limitations at the genetic level, especially for determining which genes are altered to control illness, because this method is mostly used for phenotypic determination In addition, this method is limited to determining exactly which pathogenic substrates cause inflammation or increase the permeability of the worms’ intestines during infection. Therefore, further in-depth studies, including investigation of the mol. genetic mechanism using mutant bacteria and nematodes as well as chem. component anal. of bacteria, are required to fully evaluate the function of bacteria and chems. in determining intestinal permeability.

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Mattiazzi, Juliane; Marcondes Sari, Marcel Henrique; Brum, Taine de Bastos; Araujo, Paulo Cesar Oliveira; Nadal, Jessica Mendes; Farago, Paulo Vitor; Nogueira, Cristina Wayne; Cruz, Leticia published an article about the compound: 3,3′-Diindolylmethane( cas:1968-05-4,SMILESS:C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4 ).SDS of cas: 1968-05-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1968-05-4) through the article.

This study aimed to characterize the physicochem. properties of (DIM)-loaded (NCs) as well as the antinociceptive effect using distinct animal models (hot plate test, formalin-induced nociception and complete Freud’s adjuvant induced paw inflammation). The physicochem. characterization demonstrated that DIM could be molecularly dispersed into the NCs, whose size was nanometric with a spherical shape. An improvement in thermal stability was achieved by its encapsulation and there were no interactions among the formula components. For the nociceptive evaluation, male adult Swiss mice were pretreated with the NCs or free DIM by the intragastric route at the dose of (time-response curve), (dose-response curve). Both free and nanoencapsulated DIM reduced the mech. hypernociception induced by CFA, mitigated nociceptive behavior of formalin-induced neurogenic and inflammatory pain and increased paw withdrawal latency assessed by the hot-plate test. Importantly, the nanoencapsulation promoted a rapid initiation and prolonged the bioactive antinociceptive action as well as reduced the ED in comparison to its free form. In summary, this study reported that the NCs had adequate nanometric size, increased DIM stability and its antinociceptive action in different animal models, suggesting that the formulation may be a possible therapeutic alternative to the management of pain and inflammatory-related pathologies.

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HPLC of Formula: 1968-05-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Anti-osteoclastogenic Effects of Indole Alkaloids Isolated from Barley (Hordeum vulgare Var. Hexastichon) Grass. Author is Ha, Manh Tuan; Tran, Phuong Thao; Tran, Huynh Nguyen Khanh; Kim, Okwha; Kim, Jeong Ah; Lee, Jeong-Hyung; Min, Byung Sun.

As part of our continuous program to identify new potential candidates for controlling osteolytic bone diseases from natural products, the alkaloid fraction of barley (Hordeum vulgare var. hexastichon) grass (HVA) significantly inhibited RANKL-induced osteoclast formation and protected mice from LPS-induced bone loss. A phytochem. investigation of HVA afforded nine indole alkaloids, including one new compound [hordeumin A (1)] and eight known analogs (2-9). Of them, four (1, 2, 4, and 5) were anti-osteoclastogenic compounds Of these four, compound 5 significantly suppressed RANKL-induced osteoclast formation, actin ring formation, and bone resorption in a concentration-dependent manner. It also suppressed the RANKL-induced NF-κB and MAPK signaling pathways and the activation of c-Fos and NFATc1. Compound 5 also reduced the expression levels of osteoclast-specific marker genes, including TRAP, CtsK, DC-STAMP, OSCAR, and MMP9. Our findings suggest that HVA and its alkaloid constituents could be valuable candidates for the prevention and treatment of osteolytic bone diseases.

Here is a brief introduction to this compound(1968-05-4)HPLC of Formula: 1968-05-4, if you want to know about other compounds related to this compound(1968-05-4), you can read my other articles.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3,3′-Diindolylmethane( cas:1968-05-4 ) is researched.Application In Synthesis of 3,3′-Diindolylmethane.Tsao, Chih-Wei; Li, Jia-Sin; Lin, Ya-Wen; Wu, Sheng-Tang; Cha, Tai-Lung; Liu, Chin-Yu published the article 《Regulation of carcinogenesis and mediation through Wnt/β-catenin signaling by 3,3-diindolylmethane in an enzalutamide-resistant prostate cancer cell line》 about this compound( cas:1968-05-4 ) in Scientific Reports. Keywords: enzalutamide Wnt diindolylmethane prostate cancer cell carcinogenesis. Let’s learn more about this compound (cas:1968-05-4).

Enzalutamide (ENZ) is an important drug used to treat castration-resistant prostate cancer (CRPC), which inhibits androgen receptor (AR) signaling. Previous study showed that 3,3-diindolylmethane (DIM) is an AR antagonist that also inhibits Wnt signaling and epithelial-mesenchymal transition (EMT). To investigate whether combined treatment with ENZ and DIM can overcome ENZ resistance by regulating Wnt signaling to inhibit AR signaling and EMT in ENZ-resistant prostate cancer cells, 22Rv1 cells were cultured in normal medium and treated with ENZ, DIM, and DIM with ENZ. Exposure of ENZ-resistant cells to both DIM and ENZ significantly inhibited cell proliferation without cytotoxicity and invasion in comparison with the control. DIM significantly increased the E-cadherin expression and inhibited the expressions of Vimentin and Fibronectin, subsequently inhibiting EMT. Co-treatment with ENZ and DIM significantly increased the expressions of GSK3β and APC and decreased the β-catenin protein expression, causing inhibition of Wnt signaling and AR expression, it also significantly decreased the AR-v7 expression and down-regulated AR signaling. Via suppression of Wnt and AR signaling, co-treatment increased the E-cadherin and decreased the Vimentin and Fibronectin RNA and protein expressions, then inhibited EMT. Co-treatment with DIM and ENZ regulated Wnt signaling to reduce not only the AR expression, but also the AR-v7 expression, indicating suppression of EMT that inhibits cancer cell proliferation, invasion and migration to ameliorate ENZ resistance.

Here is a brief introduction to this compound(1968-05-4)Application In Synthesis of 3,3′-Diindolylmethane, if you want to know about other compounds related to this compound(1968-05-4), you can read my other articles.

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Computed Properties of C17H14N2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Pentafluorophenyl substitution of natural di(indol-3-yl)methane strongly enhances growth inhibition and apoptosis induction in various cancer cell lines. Author is Ahmad, Aamir; Dandawate, Prasad; Schruefer, Sebastian; Padhye, Subhash; Sarkar, Fazlul H.; Schobert, Rainer; Biersack, Bernhard.

Di(indol-3-yl)methane (=3,3′-methanediyldi(1H-indole), DIM, (1)) is a known weakly antitumoral compound formed by digestion of indole-3-carbinol (=1H-indol-3-ylmethanol), an ingredient of various Brassica vegetables. Out of a series of nine fluoroaryl derivatives of 1, three pentafluorophenyl derivatives 2c, 2h, and 2i were identified that exhibited a two to five times greater anti-proliferative effect and an increased apoptosis induction when compared with 1 in the following carcinoma cell lines: BxPC-3 pancreas, LNCaP prostate, C4-2B prostate, PC3 prostate and the triple-neg. MDA-MB-231 breast carcinoma. Compound 2h was particularly efficacious against androgen-refractory C4-2B prostate cancer cells (IC50=6.4 μM) and 2i against androgen-responsive LNCaP cells (IC50=6.2 μM). In addition, 2c and 2h exhibited distinct activity in three cancer cell lines resistant to 1.

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HPLC of Formula: 1968-05-4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Efficient Sky-Blue Organic Light-Emitting Diodes Using a Highly Horizontally Oriented Thermally Activated Delayed Fluorescence Emitter. Author is Zhang, Zhen; Crovini, Ettore; dos Santos, Paloma L.; Naqvi, Bilal A.; Cordes, David B.; Slawin, Alexandra M. Z.; Sahay, Prakhar; Bruetting, Wolfgang; Samuel, Ifor D. W.; Braese, Stefan; Zysman-Colman, Eli.

Organic thermally activated delayed fluorescent (TADF) materials can harvest 100% of the elec. generated excitons as a result of their small singlet-triplet energy difference. However, maximizing the external quantum efficiency (EQE) of a device also requires enhancing the light out-coupling efficiency. This work presents a new acceptor-donor-acceptor (ADA) emitter employing an indolocarbazole donor and diphenyltriazine acceptors that show nearly-completely horizontal orientation regardless of the host matrix, leading to a sky-blue organic light-emitting diode (λEL = 483 nm, CIE coordinates of 0.17, 0.32) with EQEMAX of 22.1%, a maximum luminance of 7800 cd m-2, and blue emission.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called 3,3′-Diindolylmethane Inhibits TNF-α- and TGF-β-Induced Epithelial-Mesenchymal Transition in Breast Cancer Cells, published in 2019, which mentions a compound: 1968-05-4, mainly applied to breast cancer DIM EMT ERK1 Smad2 vimentin fibronectin phosphorylation, Application of 1968-05-4.

Epithelial-mesenchymal transition (EMT) is the initial event required by cancer cells. Thus, inhibition of the EMT process could have potential benefits for preventing the spread of cancers. The phytochems. have been reported to have inhibitory activity against the EMT process in breast cancers, but the mechanism behind this effect has not been fully elucidated.3,3′-Diindolylmethane (DIM) is a major indole derived from bioactive compounds in cruciferous vegetables. In this study, we examined the effects of DIM cotreatment together with TNF-α/TGF-β on the EMT process as well as the mechanisms underlying its effects on human breast cancer cells. DIM significantly enhanced the mRNA and protein expression of E-cadherin and occludin in MCF-7 cells. The protein expression levels of E-cadherin and occludin in MCF-7 cells were significantly decreased after TNF-α/TGF-β treatment alone, but these effects were reversed by the DIM co-treatment. Furthermore, DIM with TNF-α/TGF-β co-treatment attenuated the phosphorylation of Smad2/3 and ERK1/2 proteins. DIM significantly inhibited the TNF-α/TGF-β-induced migration of breast cancer cells. Taken together, the results indicated that DIM effectively suppressed EMT processes through the inhibition of TNF-α/TGF-β-associated signaling pathways in breast cancer cells. Thus, DIM may be a novel preventive and/or therapeutic approach for the treatment of breast cancers.

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