Category: 19752-55-7

Adding a certain compound to certain chemical reactions, such as: 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19752-55-7, SDS of cas: 19752-55-7

EXAMPLE 2 27 Grams of powdery magnesium (purity 99.5percent) was dispersed in 200 ml of diethyl ether. A solution obtained by dissolving 226 g of 1-bromo-3,5-dichlorobenzene in 800 ml of diethyl ether was added dropwise to the dispersion heated at about 40° C., and after the addition, the mixture was stirred at the same temperature for 2 hours to react them whereby 3,5-dichlorophenylmagnesium bromide was produced.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-3,5-dichlorobenzene, and friends who are interested can also refer to it.

Reference:
Patent; Ishihara Sangyo Kaisha Limited; US4230642; (1980); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 19752-55-7, The chemical industry reduces the impact on the environment during synthesis 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, I believe this compound will play a more active role in future production and life.

N*3*-(3,5-Dichloro-phenyl)-l,N*5*-bis-(4-methoxy-benzyl)-N*5*-methyl-lH- [l,2,4]triazole-3,5-diamine In a 25 mL sealed tube, sodium tert-butoxide (97.9 mg, 1.02 mmol, Eq: 1.20), bis(dibenzylideneacetone)palladium (48.8 mg, 84.9 muiotaetaomicron, Eq: 0.1) and 2-di-tert-butylphosphino- 2′,4′,6′-triisopropylbiphenyl (36.0 mg, 84.9 muiotaetaomicron, Eq: 0.1) were combined with toluene (5 mL) to give a dark brown suspension. N5,l-bis(4-methoxybenzyl)-N5-methyl-lH-l,2,4-triazole-3,5- diamine (300 mg, 849 muiotaetaomicron, Eq: 1.00) and l-bromo-3,5-dichlorobenzene (230 mg, 1.02 mmol, Eq: 1.20) were added. The reaction mixture was degassed with argon for 15 min, and then heated to 110°C for 3 hours. The reaction mixture was cooled and diluted with EtOAc (50 mL), washed with H20 (25 mL) and brine (25 mL). The organic layer was dried over anhydrous MgS04, filtered and volatiles were removed under reduced pressure to yield an oil from which the compound was isolated by column chromatography (Hexanes/EtOAc = 70/30) to give an off- white solid 140 mg (33percent). MH+ 498.2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3,5-dichlorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DING, Qingjie; JIANG, Nan; WEIKERT, Robert James; WO2014/135472; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 19752-55-7,Some common heterocyclic compound, 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, molecular formula is C6H3BrCl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

It was dissolved in I-2 (68 g, 140 mmol) in a nitrogen environment in 500 mL tetrahydrofuran (THF), where the 1-bromo-3, 5-dichlorobenzene (38.0 g, 168.1 mmol) and tetrakis( triphenylphosphine) palladium was stirred into the (1.62 g, 1.4 mmol). Into a potassium carbonate (48.4 g, 350 mmol) in saturated water it was heated to reflux at 80°C for 12 hours. After the reaction was completed, the reaction solution into water and extracted with dichloromethane (DCM) and then water was removed with anhydrous MgSO4, filter and was concentrated under reduced pressure. Thus separated and purified the resulting residue was purified by flash column chromatography gave Compound I-3 (61.4 g, 87percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-3,5-dichlorobenzene, its application will become more common.

Reference:
Patent; Cheil Industries Co., Ltd; Lee, Han Ir; Yu, Uhn Sun; Kang, Dong Min; Kang, Uii Soo; Yang, Yong Tak; Oh, Jae Jin; Yu, Dong Gyu; Lee, Sang Sin; Jang, Yuna; Jung, Su Young; Han, Su Jin; Hong, Jin Suk; (59 pag.)KR2015/6758; (2015); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 19752-55-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

Under a nitrogen atmosphere, tert-butyllithium (1.3 Msolution in Pentane, 17.8 mL, 23.2 mmol) was added dropwise to a solution of 3,5-dichlorobenzene (5.0 g, 22.1mmol) in tetrahydrofuran (50 mL) over 30 min. The mixture was stirred for further 2 hours. Then threeEthyl fluoroacetate (3.30 g, 23.2 mmol) was added dropwise to the mixed solution, and the reaction was stirred for 2 hours while maintaining at -78 ° C. Remove low temperature,After gradually rising to room temperature, the reaction was kept at room temperature for 4 hours. The reaction was quenched by addition of saturated ammonium chloride solution (50 mL). Mixed solution usedThe organic phase was combined and washed with saturated brine (20 mL’2). The organic phase was separated and washed with waterDry over magnesium sulfate, filter and remove solvent. Vacuum distillation gave a colorless transparent liquid 1 (2.20 g), yield 41percent.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-3,5-dichlorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Jingmen Pharmaceutical Industry Technology Institute; Wang Yong; Li Liwei; Hu Jianmei; Gu Dongyun; Huang Daoyou; (12 pag.)CN107353189; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 19752-55-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

Under a nitrogen atmosphere, tert-butyllithium (1.3 Msolution in Pentane, 17.8 mL, 23.2 mmol) was added dropwise to a solution of 3,5-dichlorobenzene (5.0 g, 22.1mmol) in tetrahydrofuran (50 mL) over 30 min. The mixture was stirred for further 2 hours. Then threeEthyl fluoroacetate (3.30 g, 23.2 mmol) was added dropwise to the mixed solution, and the reaction was stirred for 2 hours while maintaining at -78 ° C. Remove low temperature,After gradually rising to room temperature, the reaction was kept at room temperature for 4 hours. The reaction was quenched by addition of saturated ammonium chloride solution (50 mL). Mixed solution usedThe organic phase was combined and washed with saturated brine (20 mL’2). The organic phase was separated and washed with waterDry over magnesium sulfate, filter and remove solvent. Vacuum distillation gave a colorless transparent liquid 1 (2.20 g), yield 41percent.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-3,5-dichlorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Jingmen Pharmaceutical Industry Technology Institute; Wang Yong; Li Liwei; Hu Jianmei; Gu Dongyun; Huang Daoyou; (12 pag.)CN107353189; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, A new synthetic method of this compound is introduced below., SDS of cas: 19752-55-7

3,5-dichlorobromobenzene (2.3 g, 10 mmol), 9-phenylcarbazole-3-boronic acid (2.5 g, 11 mmol) Sodium carbonate (5.1 g, 48 mmol), Pd2 (dba) 3 (0.4 g, 0.4 mmo 1), Toluene, ethanol, water 50ml in turn added to the reaction bottle, The reaction was refluxed under nitrogen for 10 hours, Cooled to room temperature, separated, and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, washed with saturated brine and water respectively. The organic layer was dried over magnesium sulfate, filtered, The column was silica gel to give 3.0 g of product, HPLC purity 99.2percent.

The synthetic route of 19752-55-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CECEP Wanrun Co., Ltd.; Li Chong; Yu Kaichao; Zhang Zhaochao; (42 pag.)CN107098918; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 19752-55-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

A 250 ml round-bottom flask was argonated and consecutively charged with Et2O (60 ml), Mg (1.31 g; 54.0 mmol), I2(one crystal), and a solution of 1-bromo-3,5-dichlorobenzene (12.54 g; 55.5 mmol) in Et2O (60 ml) was added in ca. 5 ml portions over 45 min. Stirring was continued for 3 h at RT, and a solution of 9c (9.52 g; 18.0 mmol) in hot toluene (60 ml, ca. 90 °C) was added slowly, and the mixture was heated to 40 °C for 15 h. A precipitate was decanted, washed with toluene (2 30 ml), treated with concd HClaq. (100 ml) at reflux for 3 h, and cooled to RT. The resulted precipitate was filtered, washedwith concd HClaq. (2 30 ml), and dried. Then, most of the beige solid was dissolved in a hot mixture of water (40 ml), concd HClaq. (120 ml) and ethanol (30 ml), resulted solution was decanted, cooled to RT, and part of the solvent (ca. 50 ml) wasslowly evaporated under reduced pressure. The resulted suspension was filtered, and collected filtrate was washed with concdHClaq. (2 30 ml), and dissolved in CH2Cl2 (150 ml). The organic phase was washed with brine (100 ml), and dried overMgSO4. Then, the mixture was filtered, n-heptane (40 ml) was added, and the mixture was slowly evaporated at 300 mbar (very slow rotations, no heating bath applied). The resulted precipitate was filtered, washed with n-hexane, and dried in vacuo. Filtrate was evaporated and the crystallization procedure was repeated. Both crops were collected and combined to obtain 10c (6.70 g; 9.07 mmol; 50percent calculated as a bromide) as a white solid.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-3,5-dichlorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Article; Grudzie?, Krzysztof; Basak, Tymoteusz; Barbasiewicz, Micha?; Wojciechowski, Tomasz M.; Fedory?ski, Micha?; Journal of Fluorine Chemistry; vol. 197; (2017); p. 106 – 110;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 19752-55-7, A common heterocyclic compound, 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, molecular formula is C6H3BrCl2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 7B (31.2 g, 55.57 mmol) and Reagent 4 (12.6 g, 55.57 mmol) were put into 300 ml of tetrahydrofuran under a nitrogen atmosphere, and the resulting mixture was stirred and refluxed. Thereafter, potassium carbonate (23.0 g, 167.70 mmol) was dissolved in 800 ml of water, the resulting solution was introduced into the mixture, the resulting mixture was sufficiently stirred, and then tetrakistriphenyl-phosphinopalladium (1.9 g, 1.67 mmol) was introduced thereinto. After the reaction for 12 hours, the temperature of the product was lowered to normal temperature and a produced solid was filtered. After the filtration, the solid was washed with 100 ml of tetrahydrofuran, 500 ml of ethyl acetate, 500 ml of water, and 300 ml of ethanol. The resulting product was dried to prepare Compound 7C (26 g, 80percent). Reagent 4 was purchased from Aldrich.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; LG Chem, Ltd.; Jung, Min Woo; Lee, Dong Hoon; Huh, Jungoh; Jang, Boonjae; Kang, Minyoung; Heo, Dong Uk; Han, Miyeon; (52 pag.)US2018/244630; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, This compound has unique chemical properties. The synthetic route is as follows., name: 1-Bromo-3,5-dichlorobenzene

In the environment of nitrogen dissolved in I-20(85 g, 179 mmol) 700 mL of tetrahydrofuran (THF), where the 1-bromo-3,5-dichlorobenzene(48.5 g, 215 mmol) and tetrakis( triphenylphosphine) palladium was stirred into the (2.07 g, 1.79 mmol).Into a saturated potassium carbonate in water (61.8 g, 448 mmol) was heated to reflux at 80 ° C for 7 hours. After the reaction was completed, the reaction solution into water and extracted with dichloromethane (DCM) and then water was removed with anhydrous MgSO4, filter and was concentrated under reduced pressure. Thus separated and purified theresulting residue was purified by flash column chromatography compound to obtain a I-21(72.6 g, 82percent)

According to the analysis of related databases, 19752-55-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Cheil Industries Co., Ltd; Lee, Han Ir; Yu, Uhn Sun; Kang, Dong Min; Kang, Uii Soo; Yang, Yong Tak; Oh, Jae Jin; Yu, Dong Gyu; Lee, Sang Sin; Jang, Yuna; Jung, Su Young; Han, Su Jin; Hong, Jin Suk; (59 pag.)KR2015/6758; (2015); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19752-55-7, category: chlorides-buliding-blocks

Example S.3: Synthesis of 3,5-dichloro-2,2,2-trifluoro acetophenone (Compound example no.2 of table C.1 ); To 5.1 g (0.209 mol) Magnesium turnings was added 0.45 g of a 1 molar solution of DIBAL in hexane at 6O0C. After 15 min, 3,5-dichloro-bromobenzene (5.0 g, 0.022 mol) and 25 mL THF were added and the mixture was stirred. After start up of the reaction a mixture of 45g (0.2 mol) 3,5-dichloro-bromobenzene and 250 mL THF was added under reflux. After completion of the reaction the mixture was cooled to 00C and 31.1 g (0.219 mol) ethyl trifluoroacetate was added. After 2 h an aqueous solution of NH4CI was added an the mixture was separated between MTBE and aqueous NH4CI solution. The organic layer was separated and the solvent was removed in vacuum. (34.3g brown oil; purity 70percent ace. to g.c; yield 50percent)1H-NMR (360 MHz, CDCI3): delta = 7.7 (s, 1 H), 7.9 (s, 2H) ppm.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; BASF SE; Rack, Michael; Koerber, Karsten; WO2010/125130; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics