Wang, Hongjian; Lv, Kai; Li, Xiaoning; Wang, Bo; Wang, Apeng; Tao, Zeyu; Geng, Yunhe; Wang, Bin; Huang, Menghao; Liu, Mingliang; Guo, Huiyuan; Lu, Yu published an article on February 28 ,2019. The article was titled 《Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives》, and you may find the article in Chinese Chemical Letters.Category: chlorides-buliding-blocks The information in the text is summarized as follows:
A series of nitrobenzamide derivatives containing N-benzyl or N-pyridinylmethyl moieties I [R = H, 5-CF3, 5-F, etc.; R1 = F, 4-chloro-1-piperidyl, 4-(4-fluorophenyl)piperazin-1-yl, etc.; X = Y = CH; X = CH, Y = N; X = N, Y = CH] was designed and synthesized as new anti-tubercular agents. Many of synthesized compounds I exhibited potent in vitro antitubercular activity. Four compounds I [R = 5-NO2; R1 = 4-MeO, 4-(trifluoromethyl)-1-piperidyl, 4-chloro-1-piperidyl, 4-(4-fluorophenyl)piperazin-1-yl] had not only the same excellent MIC values against both drug-sensitive MTB strain H37Rv and two drug-resistant clin. isolates as PBTZ169 and the lead I [R = 5-NO2; R1 = 4-(trifluoromethyl)-1-piperidyl; X = Y = CH], but also acceptable safety indexes. In the part of experimental materials, we found many familiar compounds, such as 2,4-Dichloro-5-nitrobenzoic acid(cas: 19861-62-2Category: chlorides-buliding-blocks)
2,4-Dichloro-5-nitrobenzoic acid(cas: 19861-62-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Category: chlorides-buliding-blocks Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics