Category: 19995-38-1

Margaretha, P. published the artcile< Synthesis by substitution of oxygen functionalities>, HPLC of Formula: 19995-38-1, the main research area is review chloroalkane preparation oxygen substitution organic synthesis.

A review of the preparation of chloroalkanes via substitution of oxygen functionalities.

Science of Synthesis published new progress about Chloroalkanes Role: SPN (Synthetic Preparation), PREP (Preparation). 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, HPLC of Formula: 19995-38-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Verma, Piyush Kumar; Prasad, K. Sujit; Varghese, Dominic; Geetharani, K. published the artcile< Cobalt(I)-Catalyzed Borylation of Unactivated Alkyl Bromides and Chlorides>, Recommanded Product: 2-(2-Chloroethyl)thiophene, the main research area is cobalt catalyzed borylation unactivated alkyl bromide chloride diboron reagent; alkyl boronic ester preparation.

A Co-complex-catalyzed borylation of a wide range of alkyl halides with a diboron reagent (B2pin2 or B2neop2) was developed under mild reaction conditions, demonstrating the 1st Co-mediated cross-coupling with alkyl electrophiles. This protocol allows alkyl boronic esters to be accessed from alkyl halides, including alkyl chlorides, which were used rarely as coupling partners. Mechanistic studies reveal the possible involvement of an alkyl radical intermediate in this Co-mediated catalytic cycle.

Organic Letters published new progress about Boronic acids, esters Role: SPN (Synthetic Preparation), PREP (Preparation) (alkyl boronic esters). 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, Recommanded Product: 2-(2-Chloroethyl)thiophene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Heck, Richard F. published the artcile< Aromatic haloethylation with palladium and copper halides>, COA of Formula: C6H7ClS, the main research area is aromatic haloethylation palladium halide; palladium halide aromatic haloethylation; haloethylation aromatic copper halide; copper halide aromatic haloethylation.

Aryl derivatives of Group VIII metal compounds, prepared from Group VIII metal salts and mercury, tin, or lead aryls, react with olefins in the presence of cupric halides to form 2-arylethyl halides. Chlorides are formed in higher yields than bromides. The most generally useful and readily obtainable reactants were arylmercuric halides, with lithium palladium chloride as the Group VIII metal compound Since only catalytic amounts of the palladium salt are required, this reaction provides a convenient method for introducing 2-haloethyl group into aromatic systems.

Journal of the American Chemical Society published new progress about Ethylation catalysts. 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, COA of Formula: C6H7ClS.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shegavi, Mahadev L.; Agarwal, Abhishek; Bose, Shubhankar Kumar published the artcile< Efficient synthesis of alkylboronic esters via magnetically recoverable copper nanoparticle-catalyzed borylation of alkyl chlorides and bromides>, Synthetic Route of 19995-38-1, the main research area is green chem alkyl boronic ester preparation; borylation copper nanoparticle catalyst alkyl chloride bromide green chem.

We report a magnetically separable Cu nanocatalyst (Fe-DOPA-Cu) for the borylation of alkyl halides with alkoxy diboron reagents, providing alkylboronic esters in high yields, with broad functional group tolerance under mild reaction conditions. The procedure is also applicable to the borylation of benzyl chlorides and bromides. Radical clock experiments support a radical-mediated process. Easy recycling of the catalyst resulted in no significant loss of activity up to ten runs.

Green Chemistry published new progress about Adsorption. 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, Synthetic Route of 19995-38-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bhansali, Pravin; Hanigan, Christin L.; Casero, Robert A.; Tillekeratne, L. M. Viranga published the artcile< Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: Synthesis and biological evaluation>, Computed Properties of 19995-38-1, the main research area is peptidomimetic largazole enantioselective synthesis antitumor structure activity chelator zinc; cyclopeptide histone deacetylase inhibitor tubulin acetylation colon carcinoma; cyclocondensation enzymic resolution Wittig reaction aldol condensation; conjugate addition acyl transfer coupling Yamaguchi esterification macrolactamization trityl; chiral auxiliary acetyl Nagao transition state structure.

The histone deacetylase inhibitor largazole was synthesized by a convergent approach that involved several efficient and high yielding single pot multistep protocols. Initial attempts using tert-Bu as thiol protecting group proved problematic, and synthesis was accomplished by switching to the trityl protecting group. This synthetic protocol provides a convenient approach to many new largazole analogs. Three side chain analogs with multiple heteroatoms for chelation with Zn2+ were synthesized, and their biol. activities were evaluated. They were less potent than largazole in growth inhibition of HCT116 colon carcinoma cell line and in inducing increases in global H3 acetylation. Largazole and the three side chain analogs had no effect on HDAC6, as indicated by the lack of increased acetylation of α-tubulin.

Journal of Medicinal Chemistry published new progress about Acetylation. 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, Computed Properties of 19995-38-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Siyu; Sun, Minghui; Zhang, Huan; Zhang, Juan; He, Yun; Feng, Zhang published the artcile< Iron-catalyzed borylation and silylation of unactivated tertiary, secondary, and primary alkyl chlorides>, SDS of cas: 19995-38-1, the main research area is tertiary secondary primary alkyl chloride iron catalysis borylation silylation.

Herein, we describe an iron-catalyzed borylation and silylation of unactivated alkyl chlorides, delivering the tertiary, secondary, and primary alkylboronic esters, and secondary, primary alkylsilanes with high efficiency. This protocol exhibits broad substrate scope and good functional group compatibility, allowing the efficient late-stage borylation of biorelevant compounds, thus offering an excellent platform in drug discovery and development. Preliminary mechanistic studies suggest that an alkyl radical was involved in this catalytic system.

CCS Chemistry published new progress about Alkylsilanes Role: PEP (Physical, Engineering or Chemical Process), PROC (Process). 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, SDS of cas: 19995-38-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bali, Sumit; Singh, Ajai K.; Sharma, Pankaj; Toscano, R. A.; Drake, J. E.; Hursthouse, M. B.; Light, M. E. published the artcile< 2-[2-(4-Methoxyphenyltelluro)ethyl]thiophene (L1) bis[2-(2-thienyl)ethyl] telluride (L2) and their metal complexes; crystal structure of trans-dichlorobis{2-(2-(4-methoxyphenyltelluro)ethyl)thiophene-Te}palladium(II) and {bis[2-(2-thienyl)ethyl] telluride}dichloro(p-cymene)ruthenium(II)>, Quality Control of 19995-38-1, the main research area is methoxyphenyltelluroethylthiophene preparation transition metal complex; crystal structure palladium methoxyphenyltelluroethylthiophene ruthenium; bisthienylethyltelluride preparation palladium ruthenium complex.

The reaction of ArTe- (Ar = 4-MeOC6H4) and Te2- generated in situ by borohydride reduction of Ar2Te2 and Te, resp., with 2-(2-thienyl)ethyl chloride resulted in 2-[2-(4-methoxyphenyltelluro)ethyl]thiophene (L1) and bis[2-(2-thienyl)ethyl] telluride (L2), resp. Their complexes [AgNO3(L1)] (1) [PdCl2(L1)2] (2) [PtCl2(L1)2] (3) [HgBr2(L1)]2 (4) [Ru(p-cymene)Cl2(L1)] (5) [Ru(p-cymene)Cl2(L2)] (6) and [PdCl2(L2)2] were synthesized. The ligands and complexes exhibit characteristic 1H and 13C{1H} NMR spectra. Both the ligands coordinate only through Te in all the complexes. The single crystals of 2 and 6 were characterized by x-ray diffraction. Compound 2 has square planar geometry around Pd and trans arrangement of ligands. The Pd-Te bond distances 2.5951(7) and 2.5872(7) Å are longer than the values expected due to strong trans influence. The unique intermol. secondary Te···Cl interaction (distance = 3.450/3.449 Å) between neighboring mols. was observed in the crystal structure of 2. The distance between Pd atoms of two neighboring mols. 3.2143(10) Å also was found less than the sum of van der Waals radii 3.26 Å. These secondary interactions in 2 gave a dimeric species, which remains intact even in the solution Compound 6 is a half sandwich having three coordination sites occupied by two Cl atoms and the Te atom of L2 with Ru-Te bond distance of 2.6528(9) Å and Ru-Cl, 2.415(2)/2.422(2) Å.

Journal of Organometallic Chemistry published new progress about Crystal structure. 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, Quality Control of 19995-38-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Salmeia, Khalifah A.; Hodali, Hamdallah A. published the artcile< Palladium complexes with some phosphorus-sulfur ligands>, COA of Formula: C6H7ClS, the main research area is phosphinoalkylthiophene preparation complexation palladium; thiomethylphenylphosphine preparation complexation palladium; palladium phosphinoalkylthiophene thiomethylphenylphosphine complex preparation.

The P-S asym. ligands 2-(2-diphenylphosphinoethyl)thiophene (P-S2), 2-(3-diphenylphosphinopropyl)thiophene (P-S3), and [2-[(methylthio)methyl]phenyl]diphenylphosphine (P-SM) were synthesized and characterized by IR, 1H-NMR, and 13C-NMR spectroscopy. Reaction of P-S2, P-S3 or P-SM with equimolar amount of [Pd(PhCN)2Cl2] gave [Pd(P-S2)Cl2], [Pd(P-SM)Cl2] and [Pd(P-S3)(μ-Cl)Cl]2, resp. However, reaction of P-S2 with [Pd(PhCN)2Cl2] in a molar ratio of 2:1 afforded [Pd(P-S2)2Cl2]. The above complexes were characterized by microelemental anal., IR, 1H-NMR and 13C-NMR.

Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry published new progress about 19995-38-1. 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, COA of Formula: C6H7ClS.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chevreuil, Francis; Landreau, Anne; Seraphin, Denis; Larcher, Gerald; Bouchara, Jean-Philippe; Richomme, Pascal published the artcile< Synthesis and antifungal activity of new thienyl and aryl conazoles>, HPLC of Formula: 19995-38-1, the main research area is fungicide synthesis thienyl aryl conazole Candida Apergillus resistance.

Recent studies reported that a first generation azole (tioconazole) was active against Candida glabrata petite mutants, a fluconazole- and voriconazole- resistant strain of fungi characterized as most azole resistant yeast by an overexpression of the efflux pumps. Therefore, monosubstituted 1-[2-(2,4-dichlorophenyl)ethyl]-1H-imidazoles differing from tioconazole by the nature of the linker and of the aromatic ring in their side-chain were synthesized and evaluated against the mutant and the wild-type strain of C. glabrata. New 2-aryl-1-azolyl-3-thienylbutan-2-ols were then designed and synthesized, and their antifungal activity was evaluated against both strains of C. glabrata and two other major human pathogenic fungi, C. albicans and Aspergillus fumigatus. These new compounds exhibited a broad spectrum activity, as well as good efficiency against the petite mutant, suggesting that they may overcome the increased expression of the efflux pumps usually observed in clin. yeast isolates resistant to current azoles.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Aspergillus fumigatus. 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, HPLC of Formula: 19995-38-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Iranpoor, N.; Firouzabadi, H.; Aghapour, Gh.; Vaez zadeh, A. R. published the artcile< Triphenylphosphine/2,3-dichloro-5,6-dicyanobenzoquinone as a new, selective and neutral system for the facile conversion of alcohols, thiols and selenols to alkyl halides in the presence of halide ions>, Name: 2-(2-Chloroethyl)thiophene, the main research area is selenol triphenylphosphine dichlorodicyanobenzoquinone halide; alc triphenylphosphine dichlorodicyanobenzoquinone halide; benzenemethanol triphenylphosphine dichlorodicyanobenzoquinone halide; benzyl alc triphenylphosphine dichlorodicyanobenzoquinone halide; DDQ triphenylphosphine halide alc selenol diol benzenemethanol; diol triphenylphosphine dichlorodicyanobenzoquinone halide; alkanethiol triphenylphosphine dichlorodicyanobenzoquinone halide; alkanol triphenylphosphine dichlorodicyanobenzoquinone halide; alkyl halide preparation alc triphenylphosphine dichlorodicyanobenzoquinone halide; chloromethyl benzene preparation triphenylphosphine dichlorodicyanobenzoquinone halide; ethanediol triphenylphosphine dichlorodicyanobenzoquinone halide dibromoethane preparation.

A mixture of triphenylphosphine (Ph3P) and 2,3-dichloro-5,6-dicyanobenzoquinone in CH2Cl2 affords a complex which in the presence of R4NX (X=Cl, Br, I) converts alcs., thiols and selenols into their corresponding alkyl halides in high yields at room temperature The method is highly selective for the conversion of 1° alcs. in the presence of 2° ones and also 1° and 2° alcs. in the presence of 3° alcs., thiols, epoxides, trimethylsilyl- and tetrahydropyranyl ethers, 1,3 dithianes, disulfides, and amides.

Tetrahedron published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, Name: 2-(2-Chloroethyl)thiophene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics