Category: 201849-17-4

Related Products of 201849-17-4, These common heterocyclic compound, 201849-17-4, name is 1-Bromo-2-chloro-5-fluoro-4-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-bromo-2-chloro-5-fluoro-4-methylbenzene (20.Og, 9Ommol), NBS(48.06g, 27Ommol) and BPO (2.18g, 9mmol) dissolved in 1,2-dichloroethane (250m1). Stirred at reflux until the starting material was consumed monitored by GO-MS and quenched with water and extracted with ethyl acetate. Organic phases collected and dried over magnesium sulfate, filtered and concentratedunder vacuum. Purified via column chromatography on silica gel with 1:1 ethyl acetate:hexaneas eluent to afford a brown oil. Yield: 32.50g (95%)1H NMR (700 MHz, 0D013) 67.91 (d, J = 7.1 Hz, 1H), 7.36 (d, J = 9.1 Hz, 1H), 6.80 (s, 1H).

Statistics shows that 1-Bromo-2-chloro-5-fluoro-4-methylbenzene is playing an increasingly important role. we look forward to future research findings about 201849-17-4.

Reference:
Patent; BASF SE; KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY; CHEN, Hu; ZHANG, Weimin; HURHANGEE, Michael; MCCULLOCH, Iain; HAYOZ, Pascal; KAELBLEIN, Daniel; (122 pag.)WO2018/104367; (2018); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 201849-17-4, These common heterocyclic compound, 201849-17-4, name is 1-Bromo-2-chloro-5-fluoro-4-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of isopropyl magnesium chloride in THF (2.0 M; 27.2 mL) was added dropwise to a mixture of 1-bromo-2-chloro-5-fluoro-4-methylbenzene (8.10 g) and THF (55 mL) at -10 C. under an argon atmosphere, followed by stirring at -10 C. for 45 minutes. A mixture of iodine (18.4 g) and THF (26 mL) was added dropwise to the reaction mixture at -75 C., followed by stirring at -75 C. for 3 hours. A saturated aqueous Na2S2O3 solution was added to the reaction mixture at -75 C., followed by stirring at room temperature for 15 minutes. Saturated aqueous sodium bicarbonate was added to the reaction mixture at room temperature, followed by extraction with EtOAc. The organic layer was washed with brine, dried over Na2SO4, and then concentrated under reduced pressure, thereby obtaining 1-chloro-4-fluoro-2-iodo-5-methylbenzene (9.71 g).

Statistics shows that 1-Bromo-2-chloro-5-fluoro-4-methylbenzene is playing an increasingly important role. we look forward to future research findings about 201849-17-4.

Reference:
Patent; ASTELLAS PHARMA INC.; ISHIHARA, Tsukasa; IKEGAI, Kazuhiro; KURIWAKI, Ikumi; HISAMICHI, Hiroyuki; TAKESHITA, Nobuaki; TAKEZAWA, Ryuichi; US2014/364421; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics