Electric Literature of 202925-05-1,Some common heterocyclic compound, 202925-05-1, name is 4-Chloro-3,5-dibromotoluene, molecular formula is C7H5Br2Cl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 7-10 4-[8-(4-Chloro-3,5-dicyclopropylbenzyl)-2-oxo-l-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoic acid, TFA saltStep 1. Synthesis of I,3-dibromo-5-(bromomethyI)-2~chlorobenzene To l,3-dibromo-2-chloro-5-methylbenzene (1000 mg, 3.52 mmol) was added NBS (688 mg, 3.87 mmol) and AIBN (57.7 mg, 0.352 mmol). The mixture was stirred at room temperature for 30 minutes and then heated to 80 C overnight. The solution was evaporated and the residue was purified by silica gel chromatography (0-5% EtOAc/heaxnes) to provide the title compound (740 mg) as a clear oil
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Chloro-3,5-dibromotoluene, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; DUFFY, Joseph, L.; BAO, Jianming; ONDEYKA, Debra, L.; TYAGARAJAN, Sriram; SHAO, Patrick; YE, Feng; KATIPALLY, Revathi; ZWICKER, Aaron; SHERER, Edward, C.; PLOTKIN, Michael A.; MONINGKA, Remond; HUSSIAN, Zahid; WOOD, Harold B.; UJJAINWALLA, Feroze; ROMERO, Anthony; FINKE, Paul; ZANG, Yi; LIU, Weiguo; WO2012/24183; (2012); A1;,
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