Category: 203436-45-7

Synthesis and properties of 2-guanidinopurines was written by Cesnek, Michal;Masojidkova, Milena;Holy, Antonin;Solinova, Veronika;Koval, Dusan;Kasicka, Vaclav. And the article was included in Collection of Czechoslovak Chemical Communications in 2006.Recommanded Product: 203436-45-7 This article mentions the following:

2-Guanidinopurines were prepared as derivatives of 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]-9H-purine (PMEDAP) (I), which shows an important antiviral activity. It completes earlier described synthesis of 6-guanidinopurine derivatives The title compounds were obtained by the reaction of the corresponding 2-chloropurines with guanidine. 2- And 6-guanidinopurines were used as model compounds for determination of dissociation constants (pK_a) of their ionogenic groups by capillary zone electrophoresis. The pK_a values of ionogenic groups of the above compounds were compared with those of the corresponding aminopurines. The pK_a of guanidino group at the purine moiety varies from 7.77 to 10.32. There is no protonation of N¹-position in contrast to aminopurines. None of these compounds showed any antiviral activity. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Recommanded Product: 203436-45-7).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 203436-45-7

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, characterization and in vitro cytotoxicity of the first palladium(II) oxalato complexes involving adenine-based ligands was written by Starha, Pavel;Travnicek, Zdenek;Popa, Igor. And the article was included in Journal of Inorganic Biochemistry in 2009.COA of Formula: C8H8Cl2N4 This article mentions the following:

The 1st [Pd(Lⁿ)₂(ox)]xH₂O oxalato (ox) complexes involving 2-chloro-N6-(benzyl)-9-isopropyladenine (L¹; complex 1), 2-chloro-N6-(4-methoxybenzyl)-9-isopropyladenine (L²; 2), 2-chloro-N6-(2,3-dimethoxybenzyl)-9-isopropyladenine (L³; 3), 2-chloro-N6-(2,4-dimethoxybenzyl)-9-isopropyladenine (L⁴; 4), and 2-chloro-N6-(4-methylbenzyl)-9-isopropyladenine (L⁵; 5) were synthesized by the reactions of potassium bis(oxalato)palladate(II) dihydrate, [K₂Pd(ox)₂]路2H₂O, with the mentioned organic compounds (H₂ox = oxalic acid; x = 0 for 1–3 and 5 or 2 for 4). Elemental analyses (C, H, N), FTIR, Raman and NMR (¹H, ¹³C, ¹⁵N) spectroscopies, conductivity measurements and thermal studies (TGA and DTA, TG/DTA) were used to characterize the prepared complexes. The mol. structures of [Pd(L²)₂(ox)] (2) and [Pd(L⁵)₂(ox)]路L⁵路Me₂CO (5路L⁵路Me₂CO) were determined by a single crystal x-ray anal. The geometry of these complexes is slightly distorted square-planar with two appropriate Lⁿ (n = 2 or 5) mols. mutually arranged in the head-to-head (2) or head-to-tail (5) orientation. The Lⁿ ligands are coordinated to the central Pd(II) ion via the N7 atoms. The same conclusions regarding the binding properties of L¹-L⁵ ligands can be made based on multinuclear NMR spectra. In vitro cytotoxicity of the complexes 1–5 was evaluated against human chronic myelogenous leukemia (K562) and human breast adenocarcinoma (MCF7) cancer cell lines. Significant cytotoxicity was determined for the complexes 3 (IC₅₀ = 6.2 渭M) and 5 (IC₅₀ = 6.8 渭M) on the MCF7 cell line, which is even better than that found for the known and widely-used platinum-bearing antineoplastic drugs, i.e. oxaliplatin and cisplatin. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7COA of Formula: C8H8Cl2N4).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C8H8Cl2N4

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

4-(1-Adamantylmethyl)-N-(2-chloro-9-isopropyl-9H-purin-6-yl)aniline was written by Rouchal, Michal;Necas, Marek;Vicha, Robert. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2009.Quality Control of 2,6-Dichloro-9-isopropyl-9H-purine This article mentions the following:

The asym. unit of 4-(1-adamantylmethyl)-N-(2-chloro-9-isopropyl-9H-purin-6-yl)aniline, C₂₅H₃₀ClN₅, consists of 2 mols. with slightly different geometrical parameters. The dihedral angles between the purine and benzene rings are 39.54(5) and 23.69(5)掳 in the 2 mols. The adamantane cages consist of 3 fused cyclohexane rings in classical chair conformations, with C-C-C angles of 108(2)-111(2)掳. In the crystal, mols. are linked into dimers via 2 N-H路路路N H bonds. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Quality Control of 2,6-Dichloro-9-isopropyl-9H-purine).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Quality Control of 2,6-Dichloro-9-isopropyl-9H-purine

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2-(1-Adamantyl)-1-{4-[(2-chloro-9-isopropyl-9H-purin-6-yl)aminomethyl]phenyl}ethanone was written by Rouchal, Michal;Necas, Marek;Pires de Carvalho, Fabiana;Vicha, Robert. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2009.Synthetic Route of C8H8Cl2N4 This article mentions the following:

The structure of the title compound, C₂₇H₃₂ClN₅O, consists of two crystallog. independent conformers differing slightly in all geometric parameters. Both contain nearly planar purine and benzene ring systems [maximum deviations of 0.046 (3) and 0.005 (2) 脜, resp.], the dihedral angles between them being 76.44 (6) and 82.39 (6)掳, and an adamantane cage consisting of three fused cyclohexane rings in almost ideal chair conformations, with C-C-C angles in the range 108.7 (2)-110.6 (2)掳. The carbonyl plane and the benzene ring are almost coplanar [dihedral angles of 6.43 (9) and 0.64 (8)掳 in the two conformers]. The crystal structure is stabilized by intermol. N-H…N interactions that link adjacent mols. into dimers and by some non-bonding contacts of the C-H…Cl type. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Synthetic Route of C8H8Cl2N4).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Synthetic Route of C8H8Cl2N4

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In vitro biotransformation of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine by mouse liver microsomes was written by Rypka, M.;Vesely, J.;Chmela, Z.;Riegrova, D.;Cervenkova, K.;Havlicek, L.;Lemr, K.;Hanus, J.;Cerny, B.;Lukes, J.;Michalikova, K.. And the article was included in Xenobiotica in 2002.Product Details of 203436-45-7 This article mentions the following:

1. Biotransformation pathways of the cyclin-dependent kinase inhibitor 6-benzylamino-2-(3-hydroxypropylamino)-9-isopropylpurine (bohemine) by mouse liver microsomes in vitro were investigated. 2. Metabolite profiles of [8-3H]-labeled bohemine were established by TLC/3H-autoradiog. and enzymic and MS analyses were used to elucidate the chem. structures of the metabolites. The structures of the main primary metabolites were confirmed by synthesis of authentic compounds 3. A schema of the primary NADPH-dependent pathways has been proposed involving N2- and N9-dealkylation, N6-debenzylation, aromatic hydroxylation, and C2 side chain oxidation of bohemine. Three of the primary metabolites detected, 6-(benzylamino)-2-(3-hydroxypropylamino)purine (M4), 6-amino-2-(3-hydroxypropylamino)-9-isopropylpurine (M5) and 6-(4-hydroxybenzylamino)-2-(3-hydroxypropylamino)-9-isopropylpurine (M6), all retaining their parent primary hydroxyl group, were subsequently shown to be converted, by a liver cytosolic NAD⁺-dependent system, into their corresponding carboxylic acids. M6 was subject to microsomal glycosidations requiring UDP-sugar donors. NADPH-dependent conversion of M6 into M5 by microsomes was also demonstrated. 4. Cytochrome P 450 (CYP) enzymes-selective inhibitors were used to identify CYPs involved in bohemine biotransformation. The findings suggested that CYP2A and CYP3A substantially contributed to the NADPH-dependent bohemine transformation in vitro. 5. The findings will facilitate experiments designed to dissect enzymic systems catalyzing clearance of C2,C6,N9-trisubstituted purine compounds from mammalian tissues. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Product Details of 203436-45-7).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 203436-45-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2-Chloro-9-isopropyl-N,N-dimethyl-9H-purin-6-amine was written by Rouchal, Michal;Necas, Marek;Vicha, Robert. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2010.Category: chlorides-buliding-blocks This article mentions the following:

In the title compound, C₁₀H₁₄ClN₅, the imidazole and pyrimidine rings are essentially planar [maximum deviation = 0.0013 (14) and 0.0207 (13) Å, resp.]. In the crystal, the mols. are linked by weak C-H…N interactions into chains parallel to the c axis and the crystal packing is stabilized by addnl. weak C-H…N and C-H…Cl interactions. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Category: chlorides-buliding-blocks).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Pharmacophore Modeling of 2,6,9-Trisubstituted Purine Derivatives and Their Potential Role as Apoptosis-Inducing Agents in Cancer Cell Lines was written by Calderon-Arancibia, Jeannette;Espinosa-Bustos, Christian;Canete-Molina, Alvaro;Tapia, Ricardo A.;Faundez, Mario;Torres, Maria Jose;Aguirre, Adam;Paulino, Margot;Salas, Cristian O.. And the article was included in Molecules in 2015.Application of 203436-45-7 This article mentions the following:

A series of 2,6,9-trisubstituted purine derivatives I (R¹ = i-Pr, Bu, i-Bu, i-Pe, Hx, Pe; R² = H, OMe) have been synthesized and investigated for their potential role as antitumor agents. Twelve compounds were obtained by a three step synthetic procedure using microwave irradiation in a pivotal step. All the synthesized compounds were evaluated in vitro to determine their potential effect on cell toxicity by the MTT method and flow cytometry anal. on four cancer cells lines and Vero cells. Three out of twelve compounds were found to be promising agents compared to a known and effective anticancer drug, etoposide, in three out of four cancer cell lines assayed with considerable selectivity. The preliminary flow cytometry data suggests that compounds mentioned above induce apoptosis on these cells. The main structural requirements for their activity for each cancer cell line were characterized with a preliminary pharmacophore model, which identified aromatic centers, hydrogen acceptor/donor center, and a hydrophobic area. These features were consistent with the cytotoxic activity of the assayed compounds In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Application of 203436-45-7).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 203436-45-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of carba-analogues of myoseverin by regioselective cross-coupling reactions of 2,6-dichloro-9-isopropylpurine was written by Hocek, Michal;Votruba, Ivan;Dvorakova, Hana. And the article was included in Tetrahedron in 2003.Recommanded Product: 2,6-Dichloro-9-isopropyl-9H-purine This article mentions the following:

A series of 9-isopropylpurine derivatives bearing 4-methoxyphenyl, 4-methoxybenzyl, (4-methoxyphenyl)ethynyl and 2-(4-methoxyphenyl)ethyl groups in positions 2 and 6 were prepared as carba-analogs of antimitotic myoseverin. Cross-coupling reactions of 2,6-dichloro-9-isopropylpurine (I) with one equivalent of (4-methoxyphenyl)boronic acid or (4-methoxybenzyl)zinc chloride gave regioselectively the 6-substituted 2-chloropurines which were used for another cross-coupling reaction with a second equivalent of the organometallic reagent. The Sonogashira reaction of I with 4-(methoxyphenyl)ethyne gave 2,6-bis[(4-methoxyphenyl)ethynyl]-9-isopropylpurine that was hydrogenated to 2,6-bis[2-(4-methoxyphenyl)ethyl]–isopropylpurine. Regioselectivity of the couplings was proved by means of ¹H-¹⁵N HMBC experiments 2,6-Bis[(4-methoxyphenyl)ethynyl]-9-isopropylpurine showed considerable cytostatic activity, while the other compounds were inactive. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Recommanded Product: 2,6-Dichloro-9-isopropyl-9H-purine).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 2,6-Dichloro-9-isopropyl-9H-purine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics