Efficient three-component synthesis of diversely substituted tetrahydro-1H-cyclopenta[c]quinolines was written by Nino, Patricia;Cabaa, Marta;Aguilar, Nuria;Terricabras, Emma;Albericio, Fernando;Fernandez, Joan-Carles. And the article was included in Indian Journal of Chemistry in 2016.Name: Methyl 3,5-dichloro-4-methylbenzoate The following contents are mentioned in the article:
The synthesis of highly functionalized substituted tetrahydro-1H-cyclopenta[c]quinoline and its reduced derivatives hexahydro-1H-cyclopenta[c]quinolines via Povarov reaction in high diastereoselectivity and high to moderate yields is described. In addition, the relative stereochem. of the α-substituent to the tetrahydroquinoline nitrogen, as well as the regioselectivity of reaction, is shown to depend upon subtle substituent effects on the aldehyde and aniline precursors. In most cases, a preference for the formation of endo diastereomeric adducts is observed but for reactions with ortho-substituted aldehydes, the formation of exo adducts is also observed The exo-diastereoselectivity is found to be higher when the bulky size of this ortho group increases. Preparation of ortho and diortho-substituted aromatic aldehyde precursors of the Povarov reaction is also reported. This study involved multiple reactions and reactants, such as Methyl 3,5-dichloro-4-methylbenzoate (cas: 203573-09-5Name: Methyl 3,5-dichloro-4-methylbenzoate).
Methyl 3,5-dichloro-4-methylbenzoate (cas: 203573-09-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Name: Methyl 3,5-dichloro-4-methylbenzoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics