Category: 204930-37-0

Application of 204930-37-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 204930-37-0 name is 5-Bromo-1,3-dichloro-2-methylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 5-bromo-1,3-dichloro-2-methylbenzene (1.4 g, 5.8 mmol) in carbon tetrachloride (20 mL) was added N-bromosuccinimide (2.6 g, 14.6 mmol) followed by benzoyl peroxide (71 mg, 0.3 mmol). The reaction was heated at reflux overnight, then cooled to room temperature and filtered through Celite. The solvent was removed in vacuo and the residue was purified via chromatography (100percent hexanes). This provided the product, 5-bromo-2-(bromomethyl)-1,3-dichlorobenzene. 1H NMR (400 MHz, CDCl3) delta 7.50 (s, 2H), 4.68 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-1,3-dichloro-2-methylbenzene, and friends who are interested can also refer to it.

Reference:
Patent; Diaz, Caroline Jean; Haffner, Curt Dale; Speake, Jason Daniel; Zhang, Cunyu; Mills, Wendy Yoon; Spearing, Paul Kenneth; Cowan, David John; Green, Gary Martin; US2010/222345; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 204930-37-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 204930-37-0, name is 5-Bromo-1,3-dichloro-2-methylbenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Preparation 10; 5-bromo-2-(bromomethyl)-l,3-dichlorobenzene; Heat to reflux a solution of 5-bromo-l,3-dichloro-2-methylbenzene (97 mg, 0.40 mmol), N-bromosuccinimide (76 mg, 0.425 mmol) and benzoyl peroxide (16 mg, 0.06 mmol) in CCl4 (5 mL) for 3 hours under N2. Cool the reaction to room temperature and concentrate to an orange residue. Purify the residue by silica gel chromatography eluting with hexanes to afford 112 mg (87percent) of the product as white crystals.

The synthetic route of 5-Bromo-1,3-dichloro-2-methylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; WALLACE, Owen, Brendan; WO2007/127726; (2007); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 204930-37-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 204930-37-0, name is 5-Bromo-1,3-dichloro-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows.

Preparation 3; 5-bromo-2-(bromomethyl)- 1 ,3-dichlorobenzene; Heat a solution of 5-bromo-l,3-dichloro-2-methylbenzene (97 mg, 0.40 mmol),N-bromosuccinimide (76 mg, 0.425 mmol) and benzoyl peroxide (16 mg, 0.06 mmol) in CCl4 (5 mL) to reflux for 3 hours under N2. Cool the reaction to room temperature and concentrate to an orange residue. Purify the residue by silica gel chromatography eluting with hexanes to afford 112 mg (87percent) of the product as white crystals.

The chemical industry reduces the impact on the environment during synthesis 5-Bromo-1,3-dichloro-2-methylbenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ELI LILLY AND COMPANY; WO2007/127763; (2007); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics