Category: 20850-43-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20850-43-5, name is 5-(Chloromethyl)benzo[d][1,3]dioxole, A new synthetic method of this compound is introduced below., Recommanded Product: 5-(Chloromethyl)benzo[d][1,3]dioxole

4- (1,3_-benzodioxol-dioxan-5-methoxy) -2_ hydroxyacetophenone Synthesis[0078] In a 500mL three-necked flask, 3.0g (0.02mol) 2 , 4-hydroxyacetophenonewas dissolved in 150mL acetone, 0.8gKI, 2.0gK 2C03, a small amount of the TBAB,heated to reflux with stirring, slowly added dropwise containing 3.14g(0.02mol) 5_-chloro-methyl-1, 3 – benzodioxol dioxane acetone 150mL. Afterthe dropwise addition, it was refluxed for one hour, cooled, filtered offsolid, and concentrated to give a pale yellow solid which was recrystallizedfrom ethanol to give white needle crystals, 4.0g,

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Southeast University; Chi, Jin; Ji, min; (19 pag.)CN103539760; (2016); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20850-43-5 as follows. HPLC of Formula: C8H7ClO2

General procedure: Suspension of the appropriate 3-amino-1,1-dioxo-1,4,2-benzodithiazine derivative 4a-h (0.5 mmol), anhydrous K2CO3 (1.5 mmol, 0.21 g) and the appropriate alkyl chloride (0.6 mmol) in dry THF (5 ml) was heated at reflux for 20-24 h, then cooled in ice-bath and filtered off. The crude product was suspended in 5 ml of water, heated gently to ca. 50 C; and cooled with vigorous stirring until granular precipitate appeared. Filtering off and washing with cold water and diluted EtOH gave pure potassium salts. 4.5.11 ;N-{2-[(1,3-Benzodioxol-5-yl)methylthio]-4-chloro-5-(3-phenyl-1,2,4-oxadiazol-5-yl)benzenesulfonyl}cyanamide potassium salt (5o) ;Starting from 4g (0.196 g) and 1,3-benzodioxol-5-ylmethyl chloride (0.102 g). Yield: 0.215 g (88%): m.p. 274-276 C; IR (KBr): nu 2923, 2179, 1625, 1585, 1560, 1500, 1488, 1362, 1349, 1253, 1226, 1143 cm-1; 1H NMR (500 MHz, DMSO-d6): delta 4.38 (s, 2H, SCH2), 6,01 (s, 2H, OCH2O), 6.90 (d, J = 7.81 Hz, 1H, Ar), 6.98 (d, J = 7.81 Hz, 1H, Ar), 7.05 (s, 1H, Ar), 7.59-7.63 (m, 3H, Ar), 7.70 (s, 1H, Ar), 8.10-8.11 (m, 2H, Ar), 8.59 (s, 1H, Ar); Anal. C23H14ClKN4O5S2 (C, H, N).

According to the analysis of related databases, 20850-43-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Brozewicz, Kamil; Slawinski, Jaroslaw; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 384 – 394;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 20850-43-5, These common heterocyclic compound, 20850-43-5, name is 5-(Chloromethyl)benzo[d][1,3]dioxole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of compound Ig: 2-(Benzo[l,3]dioxol-5-ylmethyl-methyI-amino)-ethanol. 2-(Methylamino)ethanol (22.0 g, 290 mmol) was added to a stirred solution of 3,4- methylenedioxybenzyl chloride (25.0 g, 147 mmol) in DCM (45 mL) at -780C under nitrogen. The solution was stirred for 15 minutes at -78 0C then warmed to room temperature and stirred for 16h. 1.2 M NaOH (100 mL) was added and the phases were separated. The organic layer was washed water (2 x 150 mL) and concentrated under vacuum to give 25.3 g (83%) of 2-(benzo[l,3]dioxol-5-ylmethyl- methyl-amino)-ethanol as a clear oil.

Statistics shows that 5-(Chloromethyl)benzo[d][1,3]dioxole is playing an increasingly important role. we look forward to future research findings about 20850-43-5.

Reference:
Patent; KALYPSYS, INC.; WO2007/62410; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics