Category: 210532-25-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 210532-25-5, name is 3,5-Difluorobenzene-1-sulfonyl chloride, A new synthetic method of this compound is introduced below., COA of Formula: C6H3ClF2O2S

0.3 g (1.0 mmol, 1.0 eq) of JD1001-002-8 was added to a 25 mL reactor under nitrogen protection. 3.2 mL (10.0 V) THF, 0.32 g (3 mmol, 3.1 eq) DMAP, 0.38 g (3.0 mmol, 3.0 eq) of 3,5-difluorobenzenesulfonyl chloride were added, and the reaction was stirred at room temperature for 3 hours. After completion of the reaction by TLC detection (developing agent: PE / EA = 1 / 1, UV254), the reaction was stopped, the reaction was quenched with saturated NaHCO3, and the organic phase was extracted with ethyl acetate .The organic phase was washed twice with 0.5 N hydrochloric acid, dried with anhydrous sodium sulfate, the organic phase was filtered out, the organic phase was concentrated to give a solid. The solid was separated and purified y HPLC (CH3CN/H2O=60:40) to afford 121 mg of JD 1001-1076. The yield was 40%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Kunming Jida Pharmaceutical Co., Ltd.; Zhang Poyong; Xiao Xuzhi; Shen Changnian; Guo Kun; Lin Zhigang; Chen Mengran; Zhang Yun; Wang Lijiang; (24 pag.)CN109438297; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 210532-25-5, A common heterocyclic compound, 210532-25-5, name is 3,5-Difluorobenzene-1-sulfonyl chloride, molecular formula is C6H3ClF2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 25 mL round bottom flask was added 0.10 g (0.35 mmol, 1.0 eq) of JD 1001-002-10 solid, 3.2 mL THF, 0.13 g (1.05 mmol, 3.0 eq) DMAP, 0.22 g (1.05 mmol, 3.0 eq. 3,5-difluorobenzenesulfonyl chloride, the reaction was stirred at room temperature for 3 hours, and the reaction was completed by TLC (developing solvent: PE: EA = 1:1). The organic phase was washed twice with 0.5N aqueous hydrochloric acid and dried over anhydrous sodium sulfateIt was separated and purified by high pressure liquid phase (CH3CN: H2O = 60:40), and lyophilized to obtain 16 mg of JD1001-2064 product in a yield of 9%.

The synthetic route of 210532-25-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kunming Jida Pharmaceutical Co., Ltd.; Xiao Xuzhi; Zhang Poyong; Lu Faguan; Wang Zhipeng; Chen Mengran; Guo Kun; Zhou Rui; Zhang Yun; (28 pag.)CN109593061; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 210532-25-5,Some common heterocyclic compound, 210532-25-5, name is 3,5-Difluorobenzene-1-sulfonyl chloride, molecular formula is C6H3ClF2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 3,5-difluorobenzenesulfonyl chloride (1.1 eq., 2.62 g) in dry dichloromethane (15 mL) was added dropwise to a stirred solution of 3-[4-(4-methyl- piperazin- 1 -yl)-2-nitro-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine- 1 – carboxylic acid ethyl ester dihydrochloride (5.7g, 10.85 mmol) and N,N- diisopropylethylamine (6 eq., 11.34 mL) in dry dichloromethane (100 mL) at room temperature. Stirring was continued for 20 hours. The reaction mixture was then washed with water (2×80 mL), saturated sodium hydrogenocarbonate (2×80 mL), brine (80 mL), dried over sodium sulfate, evaporated to dryness and purified by flash chromatography on silica gel, using acetone-dichlorometane 60:40 as eluant. The title compound was obtained as yellow powder (5g, 73% yield).IH-NMR (400 MHz), delta ppm, DMSOtZ6): 11.21 (s, IH), 7.67 (m, 2H), 7.54 (m, 2H), 7.44 (d, J2=2.44 Hz, IH), 7.27 (dd, Jl=8.78 Hz, J2=2.44 Hz, IH), 4.37 (q, J=7.07 Hz, 2H), 4.14 (s, 2H), 3.55 (m, 2H), 3.34 (m, 4H), 3.02 (m, 2H), 2.52 (m, 4H), 2.25 (s, 3H), 1.33 (t, J=7.07 Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Difluorobenzene-1-sulfonyl chloride, its application will become more common.

Reference:
Patent; NERVIANO MEDICAL SCIENCES S.r.l.; WO2007/68619; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 210532-25-5, name is 3,5-Difluorobenzene-1-sulfonyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 210532-25-5, Quality Control of 3,5-Difluorobenzene-1-sulfonyl chloride

General procedure: To a mixture of 3-amino-2-methyl-thieno[2,3-d]pyrimidin-4(6H)-one (1.0 mmol) (8 and 9) and benzenesulfonyl chloride (1.1 mmol) in DCM (10 mL) was added dropwise pyridine (1.2 mmol) in dichloromethane (2 mL). The resulting mixture was stirred at room temperature for 12 hrs. The mixture was concentrated under reduced pressure, and theresidue was treated with water (30 mL). The aqueous mixture was neutralized by the addition of aqueous 10% HCl solution and extracted with DCM (230 mL). The organicphase was washed with aqueous saturated NH4Cl solution and brine. The organic layer was separated and dried over anhydrous MgSO4, filtered, and concentrated under reducedpressure to give the crude product, which was purified by silica gel chromatography to produce the pure corresponding compounds.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Difluorobenzene-1-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Nie, Li Fei; Bozorov, Khurshed; Huang, Guozheng; Zhao, Jiangyu; Niu, Chao; Aisa, Haji Akber; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 193; 10; (2018); p. 656 – 667;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 210532-25-5 as follows. Formula: C6H3ClF2O2S

General procedure: A solution of 1,3-Bis(aminomethyl)benzene (100 mg, 0.73 mmol) and 0.25 ml triethylamine in 20 ml dichloromethane was stirred at 0 C. To this solution was slowly added appropriate benzamide or benzenesulfonamide (2.2 mmol) in 20 ml dichloromethane dropwise. After 10 minutes, the reaction mixture was then placed to ambient temperature and stirred for 2 hours. Upon completion, the reaction mixture was concentrated under reduced pressure. Purification by flash chromatography (silica gel, dichloromethane/methanol 40: 1) afforded a white solid.

According to the analysis of related databases, 210532-25-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chen, Yanmei; Liu, Bo; Ouyang, Liang; Pan, Dabo; Xiang, Honggang; Zhang, Jifa; Zhang, Jin; Chinese Chemical Letters; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 210532-25-5, name is 3,5-Difluorobenzene-1-sulfonyl chloride, molecular formula is C6H3ClF2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C6H3ClF2O2S

at room temperature,2-methyl-4-carbonyl-6,7,8,9-tetrahydropyrido [1,2-a] thiophene [2,3-d] pyrimidin-3-amine hydrochloride Compound 10 (0.31 g, 1m mol) was dissolved in anhydrous dichloromethane (10 ml), followed by addition3,5-difluorobenzenesulfonyl chloride (0.23 g, 1.1 mmol)Triethylamine (0.12 g, 1.2 mmol) was slowly added with stirring, stirred at room temperature overnight,Reaction to the material completely disappeared, dichloromethane extraction, concentration,Using a 5: 1 by volume petroleum ether: ethyl acetate column chromatography gradient elution,To give compound 10f; yield: 82% as a white solid

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 210532-25-5, its application will become more common.

Reference:
Patent; Shandong University; Liu Zhi; Chen Ting; Zhang Baojie; Feng Ying; Luo Xinyu; Cui Deliang; (19 pag.)CN106749315; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 210532-25-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 210532-25-5, name is 3,5-Difluorobenzene-1-sulfonyl chloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 2; N-r5-( 4-Amino-7 -isopropvl-7 H-pvrrolor2 .3-dl pvrim idine-5-carbonvl)-pvrid in-3-vll-3,5- difluoro-benzenesulfonamide; 3,5-Difluoro-benzenesulfonyl chloride (19.7 mg, 0.093 mmol) was added to a solution of (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(5-amino-pyridin-3-yl)-methanone (25 mg, 0.084 mmol) in pyridine (0.7 mL). The resulting solution was heated to 40 C for 16 h. The reaction mixture was concentrated in vacuo and the residue dissolved in DMSO (2 mL) and purified using reverse phase preparative HPLC to furnish the title compound as a white solid. MS: 473.2 (MH+) ; HPLC Rf: 4.91 min. (HPLC method 4).

The synthetic route of 3,5-Difluorobenzene-1-sulfonyl chloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2005/116035; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 210532-25-5, name is 3,5-Difluorobenzene-1-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 210532-25-5

To a suspension of 3-[2-(l,3-dioxo-l,3-dihydro-isoindol-2-ylmethyl)-benzoylamino]-6,6- dimethyl-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-2-carboxylic acid ethyl ester hydrochloride (1.24 g, 2.4 mmol) in dry dichloromethane (30 mL) was added N,N- diisopropylethylamine (1.67 mL, 9.6 mmol) and 3,5-difluorobenzenesulfonyl chloride (0.77 g, 3.6 mmol). After stirring at room temperature for 3 hours the mixture was diluted with dichloromethane (50 mL), washed with IN HCl, water, saturated solution of NaHCC>3, brine, dried over sodium sulfate and evaporated to dryness. The crude was purified by flash chromatography on silica gel eluting with ethyl acetate and then with dichloromethane/methanol 98:2 affording the title compound as white solid (1.4 g).IH-NMR (400 MHz), delta (ppm, DMSOtZ6): 10.61 (bs, IH), 7.83 (m, 4H), 7.69-7.63 (m, 4H), 7.56-7.45 (m, 2H), 7.39 (m, IH), 5.05 (s, 2H), 4.72 (bs, 2H), 4.41 (q, J=7.1 Hz, 2H), 1.67 (s, 6H), 1.34 (t, J=7.1 Hz, 3H).

The synthetic route of 3,5-Difluorobenzene-1-sulfonyl chloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NERVIANO MEDICAL SCIENCES S.r.l.; WO2007/68637; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 210532-25-5,Some common heterocyclic compound, 210532-25-5, name is 3,5-Difluorobenzene-1-sulfonyl chloride, molecular formula is C6H3ClF2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a round bottom flask under N2, 2-bromo-1-(1H-indol-3-yl)ethanone (1) (500 mg, 2.1 mmol), p-toluenesulfonyl chloride (439 mg, 2.3 mmol), DMAP (26 mg, 0.21 mmol), and triethylamine (0.3 mL, 2.1 mmol) were dissolved in 20 mL of dry CH2Cl2, and the solution was stirred at room temperature until that the starting material had disappeared by checking TLC. The reaction mixture was quenched by dilution with CH2Cl2 (30 mL), and the organic extract was washed with 1 N HCl (20 mL). The organic layer was dried over anhydrous Na2SO4, filtered and the solvent was removed under vacuum. The product was purified by silica gel column chromatography using CH2Cl2 to give 379 mg of (2a) as brown crystalline plates.

The synthetic route of 210532-25-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Vera, Gonzalo; Lagos, Carlos F.; Almendras, Sebastian; Hebel, Dan; Flores, Francisco; Valle-Corvalan, Gissella; Pessoa-Mahana, C. David; Mella-Raipan, Jaime; Montecinos, Rodrigo; Recabarren-Gajardo, Gonzalo; Molecules; vol. 21; 8; (2016);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 210532-25-5, These common heterocyclic compound, 210532-25-5, name is 3,5-Difluorobenzene-1-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred suspension of TFA salt of 9-(3-amino-propyl)-6,7,8,9-tetrahydro-5H- carbazole-3-carboxylic acid methyl ester (0.2 g, 0.5 mmol), in 2 ml of dry CH2Cl2, NEt3 (0.208 ml, 1.5 mmol) was added at 0 C. After stirring for 5 min, 3,5-difluorobenzene sulfonylchloride (0.106 g, 0.5 mmol), in 1 ml of dry CH2Cl2 was added and the mixture was stirred for 3 hrs. The reaction mixture was diluted with CH2Cl2, washed sequentially with IN HCl (25 ml), H2O (25 ml) and sat. NaHCO3 (25 ml) solution. The organic layer was separated, dried over anhyd.MgSO4, solvents removed in vacuo and the crude was purified by column chromatography, using EtOAc/hexane as eluents, to obtain 0.14g of the product. 1H NMR 500 MHz CDCl3: 8.2, d, J = 1.4, IH, 7.8, dd, J = 1.6, 8.7, IH, 7.3-7.24, m, 2H, 7.15, d, J = 8.7, IH, 7.04-6.97, m, IH, 4.48, t, J = 5.9, IH, 4.1, t, J = 7, 2H, 3.92, s, 3H, 2.98, q, J = 6.6, 2H, 2.73, t, J = 6.2, 2H, 2.66, t, J = 5.9, 2H, 2.05-1.89, m, 4H, 1.88-1.82, m, 2H.

The synthetic route of 210532-25-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ITHERX PHARMACEUTICALS, INC.; WO2009/103022; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics