Category: 2106-02-7

Some common heterocyclic compound, 2106-02-7, name is 2-Chloro-4-fluoroaniline, molecular formula is C6H5ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H5ClFN

Compound 17 (1.76 g, 10 mmole) was added to a solution of the 2-chloro-4- fluoroaniline (1.45 g, l0mmole) and pyridine (2 mL) in 15 mL of dichioromethane at 0C. The reaction mixture was allowed to warm to room temperature, and continued to stir at room temperature for 12 hours. The reaction mixture was quenched with water (20 mL), and extracted with dichloromethane (20 mL). The organic layer was separated and washed with HCI (0.4N, 10 mL) and brine, and concentrated to give the desired solid Compound 18 (2.8 g, 98%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2106-02-7, its application will become more common.

Reference:
Patent; TAIWANJ PHARMACEUTICALS CO., LTD; YANG, Syaulan S.; LEE, Kuang-Yuan; LIU, Meng-Hsien; HSIAO, Ming-Yu; PENG, Huang-Kai; WANG, Chiung-Wen; WU, Edwin SC; CHIU, Peter JS; (77 pag.)WO2018/156297; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 2106-02-7, name is 2-Chloro-4-fluoroaniline, molecular formula is C6H5ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 2106-02-7

General procedure: The synthesis of azides were carried out according to the publish procedure [59]. Briefly, aniline (1eq) was dissolved in6N HCl solution (10mL/mmol of aniline) at room temperature and cooled up to 0C, followed by addition of aqueous NaNO2 (1eq) solution under stirring. After 10min of stirring at same temperature, sodium azide (1.2eq) was added to the reaction mixture. This mixture was further stirred at room temperature for 2-3h. The reaction was worked up by extraction with chloroform. The organic layer was washed with brine solution and dried over Na2SO4. After evaporation of the solvent, the crude product (3a-r) was pure enough for further reactions. All the synthesized azides were stored at-20C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2106-02-7, its application will become more common.

Reference:
Article; Kant, Rama; Singh, Vishal; Nath, Gopal; Awasthi, Satish Kumar; Agarwal, Alka; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 218 – 228;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2106-02-7, name is 2-Chloro-4-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., 2106-02-7

Under nitrogen protection, a water separator was installed in a 2L four-necked flask, and 145.5 g of 2-chloro-4-fluoroaniline and 130 g of 4-methoxybenzaldehyde were added.Concentrated sulfuric acid 20.0g and 1.2L of toluene, Reflux water separation reaction 6h, no obvious water droplets in the water separator can stop the reaction.After cooling to room temperature, it was washed with 100 mL of 10% aqueous sodium hydroxide solution, and the organic phase was decomposed under reduced pressure.The residue obtained was distilled under reduced pressure of 10 mmHg to give the titled product, N-(4-methoxybenzylidene)-2-chloro-4-fluoroaniline, 243.9 g, gas chromatographic content 99.4%, yield 92.5%.

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Reference:
Patent; Shanghai Kangpeng Technology Co., Ltd.; Zeng Yuan; Zhou Yan; Li Bolan; Chen Xiaobin; Wang Daoxiang; Yang Jianhua; (19 pag.)CN108276294; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics