Category: 2106-04-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2106-04-9, name is 3-Chloro-2-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3-Chloro-2-fluoroaniline

[00178] Synthesis of isothiocyanate 3c[00179] Preparation of compound 18[00180] A solution of compound 17 (5g, 0.034mol) in DMF (50mL) was added a DMF solution (50mL) of NBS (6.05 g, 0.034 mol) drop-wise at room temperature. After 16h, the reaction mixture was diluted with ethyl acetate (lOOmL) and washed with brine (2xl00mL). The separated organic phase was dried over Na2S04 and concentrated to give the title compound 18 as an oil (5.0g, 65% yield). ESI-MS (M+H)+: 223.92.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2106-04-9.

Reference:
Patent; SUZHOU KINTOR PHARMACEUTICALS,INC.; TONG, Youzhi; WO2012/119559; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 2106-04-9, These common heterocyclic compound, 2106-04-9, name is 3-Chloro-2-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 .2: Ethyl-5-((3-chloro-2-fluorophenylamino)(4-chlorophenyl)methyl)-1-isopropyl-2-(2- methoxyphenyl)-1 H-imidazole-4-carboxylate 3-chloro-2-fluoroaniline (90 mg, 0.621 mmol) was added to a solution of the product of step 1.3 (242 mg, 0.477 mmol) in dioxane (5 ml) and stirred at 60C over night. 3-Chloro- 2-fluoroaniline (90 mg, 0.621 mmol) was added again to the reaction mixture and heated at 100C for 3 hr. The solution was diluted with EtOAc and washed twice with a 5% aqueous citric acid solution. The water phase was back extracted with EtOAc and the combined organic layers were washed with saturated aqueous NaHC03, dried over Na2S04 and evaporated to afford 800 mg of brown oil. The residue was purified by preparative HPLC (Waters xBridge (30 / 100 mm), 0.1 % TFA-water/0.1 % TFA-acetonitrile; gradient acetonitrile 30 to 60% in 10 min, then 5 min at 60%, 60 – 90% in 10 min and 2 min at 100%) to afford 176 mg (0.313 mmol, 65.6% yield) of the title compound. LCMS: (M+H) = 556/557; tR = 1 .46 min (LC-MS 3). HPLC: tR = 5.35 min (H PLC 2) 1 H-NMR (MeOD, 600.13 MHz) delta ppm 7.52 (t, 1 H) 7.39-7.30 (m, 5H) 7.12 (m, 1 H) 7.07 (t, 1 H) 6.96 (t, 1 H) 6.86 (t, 1 H) 6.77 (t, 1 H) 6.72-6.30 (m, 1 H) 4.37 (quin, 1 H) 4.27 (q, 2H) 3.77 (s, 3H) 1 .31 -1.05 (m, 9H)

The synthetic route of 2106-04-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; FURET, Pascal; GUAGNANO, Vito; HOLZER, Philipp; KALLEN, Joerg; MAH, Robert; MASUYA, Keiichi; SCHLAPBACH, Achim; VAUPEL, Andrea; WO2014/115077; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2106-04-9, Adding some certain compound to certain chemical reactions, such as: 2106-04-9, name is 3-Chloro-2-fluoroaniline, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2106-04-9.

Example 40 7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-(3-chloro-2-fluorophenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide To a solution of 20% phosgene in toluene (phosgene:toluene=1:4, 54.9 uL, 0.104 mmol) was added a solution of 3-chloro-2-fluoroaniline (6.5 mg, 0.045 mmol) (Aldrich, Cat. #530174) and triethylamine (19.3 uL, 0.138 mmol) in THF (0.4 mL). The resulting mixture was stirred at r.t. for 2 h., and concentrated. To the residue was added a solution of 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt (15 mg, 0.034 mmol) and triethylamine (19.3 uL, 0.138 mmol) in acetonitrile (0.4 mL). The reaction mixture was stirred at r.t. for 30 min The mixture was purified by RP-LCMS (pH=10) to afford the desired product. Analytic LCMS (M+H)+: m/z=496.1/498.1.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2106-04-9.

Reference:
Patent; INCYTE CORPORATION; US2010/240671; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics