Category: 21286-54-4

Ghosh, Harisadhan published the artcileSynthesis of axially chiral 1,8-diarylnaphthalene ligands and application in asymmetric catalysis: an intriguing fluorine effect, HPLC of Formula: 21286-54-4, the publication is Tetrahedron: Asymmetry (2015), 26(2-3), 79-84, database is CAplus.

A fluorinated and a non-fluorinated axially chiral 1,8-diarylnaphthalene ligand have been synthesized through an Ullmann and Suzuki coupling reaction based strategy. A practical methodol. for the successful chiral resolution of the newly synthesized catechol based moiety is presented. The authors also disclose the preliminary application of these axially chiral mols. as ligands in asym. transformation reactions. The synthesis of the target compounds was achieved by a reaction of 1,8-diiodonaphthalene with 1,2,3,4,5-pentafluoro-6-(iodo)benzene and formation of 1-iodo-8-(pentafluorophenyl)naphthalene. A Suzuki coupling of this aryl iodide with (2,3,6-trimethoxyphenyl)boronic acid gave a biaryl which was deprotected and resolved to deliver axially chiral biaryls 4-methoxy-3-[(1S)-8-(pentafluorophenyl)-1-naphthalenyl]-1,2-benzenediol and 4-methoxy-3-[(1R)-8-(pentafluorophenyl)-1-naphthalenyl]-1,2-benzenediol which was transformed into chiral titanium complexes.

Tetrahedron: Asymmetry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, HPLC of Formula: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yanagi, Tomoyuki published the artcileAsymmetric systematic synthesis, structures, and (chir)optical properties of a series of dihetero[8]helicenes, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Chemical Science (2021), 12(8), 2784-2793, database is CAplus and MEDLINE.

A series of dihetero[8]helicenes (P)/(M)/(rac)-I (R = O, S, NH, SO₂) have been systematically synthesized in enantiomerically enriched forms by utilizing the characteristic transformations of the organosulfur functionality. The synthetic route begins with assembling a ternaphthyl II common synthetic intermediate from 2-naphthol and 2,7-bis(phenethylsulfinyl)naphthalene through an extended Pummerer reaction followed by facile multi-gram-scale resolution The subsequent cyclization reactions into dioxa- and dithia[8]helicenes (P)/(M)/(rac)-I take place with excellent axial-to-helical chirality conversion. Dithia[8]helicenes (P)/(M)/(rac)-III are further transformed into the nitrogen (P)/(M)/(rac)-I and the carbon analogs (P)/(M)/(rac)-IV and (P)/(M)/(rac)-V by replacing the two endocyclic sulfur atoms via S_NAr-based skeletal reconstruction. The efficient systematic synthesis has enabled comprehensive evaluation of phys. properties, which has clarified the effect of the endocyclic atoms on their structures and (chir)optical properties as well as the unexpected conformational stability of the common helical framework.

Chemical Science published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15NO, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pasha, Maira published the artcileCatalytic enantioselective oxa-hetero-Diels-Alder reactions of enones with aryl trifluoromethyl ketones: synthesis of tetrahydropyranones, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Heterocycles (2021), 103(1), 198-204, database is CAplus.

Diastereo- and enantioselective oxa-hetero-Diels-Alder reactions of enones with aryl trifluoromethyl ketones that afford tetrahydropyranone derivatives catalyzed by an amine-based catalyst system are reported. The major diastereomers of the tetrahydropyranone products obtained in these reactions had the relative stereochem. different from that of the previously synthesized tetrahydropyranone derivatives

Heterocycles published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pasha, Maira published the artcileOrganocatalytic diastereo- and enantioselective oxa-hetero-Diels-Alder reactions of enones with aryl trifluoromethyl ketones for the synthesis of trifluoromethyl-substituted tetrahydropyrans, Quality Control of 21286-54-4, the publication is Organic & Biomolecular Chemistry (2021), 19(42), 9242-9250, database is CAplus and MEDLINE.

Here diastereo- and enantioselective oxa-hetero-Diels-Alder reactions catalyzed by amine-based catalyst systems that afford trifluoromethyl-substituted tetrahydropyranones was reported. Catalyst systems and conditions suitable for the reactions to provide the desired diastereomer products with high enantioselectivities were identified, and various trifluoromethyl-substituted tetrahydropyranones were synthesized with high diastereo- and enantioselectivities. Mechanistic investigation suggested that the reactions involve a [4 + 2] cycloaddition pathway, in which the enamine of the enone acts as the diene and the ketone carbonyl group of the aryl trifluoromethyl ketone acts as the dienophile. In this study, tetrahydropyran derivatives with the desired stereochem. that are difficult to synthesize by previously reported methods were concisely obtained, and the range of tetrahydropyran derivatives that can be synthesized was expanded.

Organic & Biomolecular Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Quality Control of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kim, Hun Young published the artcileReversal of Enantioselectivity Approach to BINOLs via Single and Dual 2-Naphthol Activation Modes, Quality Control of 21286-54-4, the publication is Organic Letters (2017), 19(14), 3867-3870, database is CAplus and MEDLINE.

A mechanism-driven enantiodivergent approach to chiral 1,1′-bi-2-naphthols via catalytic asym. oxidative coupling of 2-naphthol derivatives is described for the first time. By utilizing 2-naphthol derivatives with low oxidation potential, the substrates were activated by either chiral mononuclear or dinuclear vanadium(V) catalyst to promote distinctively different asym. reaction pathways: single vs. dual substrate activation mechanisms.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Quality Control of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abd El-Meguid, Eman Ali published the artcileDiscovery of some novel benzothiazole derivatives as VEGFR-2 inhibitors, Quality Control of 21286-54-4, the publication is International Journal of Pharmacy and Technology (2015), 7(3), 10040-10055, database is CAplus.

A series of benzothiazole derivatives were prepared by condensation of 5-amino-1-(4-benzothiazol-2-yl-benzoyl)-1H-pyrazole-4-carbonitrile (1) and/or 5-amino-1-(4-benzothiazol-2-yl-benzoyl)-1H-pyrazole-4-carboxylic acid hydrazide (6) with different electrophilic and nucleophilic reagents. All of the newly synthesized compounds have been evaluated for their potential cytotoxicity against breast cancer cell line (MCF-7); compounds 5c, 8b and 8c are more potent than tamoxifen while compounds 5b and 8a are equipotent to tamoxifen. These results were consistent with percentage of inhibition values against human VEGF compared with control untreated cells.

International Journal of Pharmacy and Technology published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Quality Control of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abd El-Meguid, Eman A. published the artcileSynthesis and antimicrobial evaluation of some novel sulfamoyl and triazole derivatives incorporating a 4-benzoimidazol-2-yl moiety, Related Products of chlorides-buliding-blocks, the publication is International Journal of Pharmacy and Technology (2015), 7(3), 10014-10028, database is CAplus.

In this study 15 novel benzoimidazole compounds were synthesized in order to investigate their possible antibacterial and antifungal activity. Two different Gram-pos. and two different Gram-neg. bacterial strains were used in antibacterial activity tests. Antifungal activity tests were also performed against two different fungal strains. Most of the test compounds found to be significantly effective against Gram-pos., Gram-neg. bacterial strains and antifungal strains.

International Journal of Pharmacy and Technology published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yu, Bangkui published the artcilePalladium-Catalyzed Ring-Closing Reaction for the Synthesis of Saturated N-Heterocycles with Aminodienes and N,O-Acetals, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Journal of Organic Chemistry (2021), 86(11), 7849-7863, database is CAplus and MEDLINE.

An efficient palladium-catalyzed ring-closing reaction of aminodienes e.g., (E)-N-(2-(benzylamino)ethyl)-4-methyl-N-(penta-2,4-dien-1-yl)benzenesulfonamide with N,O-acetals RN(R¹)CH₂OCH₃ [R = n-Bu, Bn, (4-bromophenyl)methyl, etc.; R¹ = n-Bu, Bn, (4-bromophenyl)methyl, etc.; RR¹ = -(CH₂)₂O(CH₂)₂-] for the synthesis of saturated N-heterocycles e.g., (E)-N,N-dibenzyl-3-(1-benzyl-4-tosyl-1,4-diazepan-6-yl)prop-2-en-1-amine is described. The reaction is consistently operated at room temperature and tolerates a wide range of functional groups with volatile MeOH as the sole byproduct. This method provides rapid and practical access to a broad range of saturated N-heterocycles e.g., (E)-N,N-dibenzyl-3-(1-benzyl-4-tosyl-1,4-diazepan-6-yl)prop-2-en-1-amine with diverse structural backbones that are useful building blocks in natural product synthesis and drug discovery.

Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C12H14BNO2, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhao, Yu published the artcileThe Copper-Catalyzed Reaction of 2-(1-Hydroxyprop-2-yn-1-yl)phenols with Sulfonyl Azides Leading to C3-Unsubstituted N-Sulfonyl-2-iminocoumarins, Application In Synthesis of 21286-54-4, the publication is Journal of Organic Chemistry (2021), 86(13), 9155-9162, database is CAplus and MEDLINE.

An operationally simple synthesis of Z-configured and C3-unsubstituted N-sulfonyl-2-iminocoumarins I [R¹ = H, 6-Br, 6-Cl, 6-Me; R² = H, Me; R³ = Me, Ph, 4-ClC₆H₄, etc.] was achieved by reacting 2-(1-hydroxyprop-2-yn-1-yl)phenols with sulfonyl azides. The cascade process involved likely starts with a copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. This was followed by ring-opening of the resulting metalated triazole (with accompanying loss of nitrogen), reaction of the ensuing ketenimine with the pendant phenolic hydroxyl group and finally dehydration of the (Z)-N-(4-hydroxychroman-2-ylidene)sulfonamide so formed.

Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C3H5BN2O2, Application In Synthesis of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gong, Kai published the artcileFrom symmetrical tetrasulfides to trisulfide dioxides via photocatalysis, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Green Chemistry (2021), 23(24), 9865-9869, database is CAplus.

A straightforward strategy involving photocatalysis has been established for accessing trisulfide dioxides R¹SSSO₂R² (R¹ = Et, t-Bu, 1-adamantyl, 2-MeC₆H₄, etc.; R² = cyclopropyl, Ph, 4-FC₆H₄, 2-thienyl, etc.) from readily achieved sym. tetrasulfides R¹S₄R¹ and sulfinic acids R²SO₂H. Stern-Volmer anal. and radical quenching experiments demonstrated the occurrence of a single electron transfer between the photocatalyst and sulfinic acid. Bioactive mols. such as the antihypertensive drug captopril, allicin derivatives, amino acids and terpenes were efficiently and reversibly linked through sulfur-sulfur covalent bonds. Furthermore, flow-setup syntheses of trisulfide dioxides were successfully achieved on the gram scale, indicating the great potential of the developed protocol for practical industrial applications.

Green Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics