Category: 21286-54-4

Mao, Liu-Liang published the artcileVisible-light-induced sulfonylation/cyclization of vinyl azides: one-pot construction of 6-(sulfonylmethyl)phenanthridines, Application In Synthesis of 21286-54-4, the publication is Organic Chemistry Frontiers (2018), 5(2), 232-236, database is CAplus.

Visible-light-induced sulfonylation/cyclization of vinyl azides were developed for the synthesis of 6-(sulfonylmethyl)phenanthridines. This facile and efficient approach used simple and readily available sulfonyl chlorides as the sulfonylation reagent for the construction of C-S bonds and triggered the formation of the C-N bond with mild conditions, broad substrate scope and high functional group tolerance.

Organic Chemistry Frontiers published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Application In Synthesis of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Lixin published the artcilePalladium-Catalyzed Dehydrogenative Difunctionalization of Aminoalkenes with Aminals as Oxidants and Electrophiles, SDS of cas: 21286-54-4, the publication is Organic Letters (2017), 19(17), 4600-4603, database is CAplus and MEDLINE.

A novel palladium-catalyzed aminomethylamination of aminoalkenes with an aminal, functioning not only as an aminomethylation reagent but also as an oxidant, was developed. This direct and operationally simple protocol provides a fundamentally novel and unique approach toward the synthesis of 2-(2-aminoethyl)indoles, e.g., I, and 2-(2-aminoethyl)pyrrolidines, e.g., II (X-rays single crystal structures for both compounds shown), which are important building blocks in synthetic organic chem. The unity of this method was highlighted by the rapid synthesis of Alosetron, a drug used for the treatment of irritable bowel syndrome.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, SDS of cas: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Dungai published the artcileMetal- and base-free reductive coupling reaction of P(O)-H with aryl/alkyl sulfonyl chlorides: a novel protocol for the construction of P-S-C bonds, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Organic & Biomolecular Chemistry (2017), 15(3), 545-549, database is CAplus and MEDLINE.

Novel and efficient synthesis of S-aryl/alkyl phosphinothioates from P(O)-H and aryl/alkyl sulfonyl chlorides under metal- and base-free conditions is described. This reaction provides an alternative strategy for the construction of P-S-C bonds in moderate to excellent yields. Moreover, this method can be readily applied to gram-scale preparation

Organic & Biomolecular Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C2H2N4O2, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Yuanfeng published the artcileAsymmetric Epoxidation of α,β-Unsaturated Ketones Catalyzed by Chiral Iron Complexes of (R,R)-3,4-Diaminopyrrolidine Derived N4-Ligands with Camphorsulfonyl Sidearms, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Asian Journal of Organic Chemistry (2020), 9(4), 616-621, database is CAplus.

Three (R,R)-3,4-diaminopyrrolidine-based chiral N₄ ligands and corresponding iron complexes were synthesized. The complexes were applied to the asym. epoxidation of various α,β-unsaturated ketones with H₂O₂ as an oxidant and carboxylic acid as an auxiliary. Good to excellent enantioselectivity (up to 97%) was achieved in the case of 2,2-dimethylbutyric acid as an auxiliary.

Asian Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jiang, Jun published the artcileSynthesis of N-arylsulfonamides via Fe-promoted reaction of sulfonyl halides with nitroarenes in an aqueous medium, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Organic & Biomolecular Chemistry (2018), 16(27), 5016-5020, database is CAplus and MEDLINE.

A fascinating Fe-promoted protocol for the synthesis of N-arylsulfonamides has been developed. Starting from com. available nitroarenes R¹NO₂ (R¹ = Ph, 2-ClC₆H₄, 4-HOC₆H₄, 1,2,4-triazol-3-yl, etc.) and sulfonyl chlorides R²SO₂Cl (R² = Me, Ph, 3-BrC₆H₄, 2-naphthyl, 2-thienyl, etc.), moderate to excellent yields of the corresponding N-arylsulfonamides R¹NHSO₂R² can be obtained. In particular, Fe dust serves as the sole reductant in the transformation and it can be easily performed on a large scale.

Organic & Biomolecular Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Weiyi published the artcileStereodefined rhodium-catalysed 1,4-H/D delivery for modular syntheses and deuterium integration, Quality Control of 21286-54-4, the publication is Nature Catalysis (2021), 4(7), 586-594, database is CAplus.

Here, a 1,4-H delivery of allylic metallic species to provide a highly stereoselective and straightforward approach to 3-methyl-2(E)-enals or -enones from readily available 2,3-allenols and organoboronic acids was reported. The reaction accommodated many synthetically versatile functional groups as well as multi-pharmacophores, and was not limited to the formation of 3-Me derivatives By applying 1,4-H or D delivery, deuterium atom(s) from differently deuterated allenols was edited into the Me or methylene groups of versatile organic skeletons, resulting in the efficient formation of 4-monodeuterated, 1,4- and 4,4-doubly deuterated, and 4,4,4-triply deuterated 2(E)-enals or -enones. These powerful platform mols. was provide straightforward paths to other deuterated compounds for different purposes.

Nature Catalysis published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C17H29BO2, Quality Control of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Shaotong published the artcileA stereo configuration-activity study of 3-iodo-4-(2-methylcyclohexyloxy)-6-phenethylpyridin-2(2H)-ones as potency inhibitors of HIV-1 variants, HPLC of Formula: 21286-54-4, the publication is Organic & Biomolecular Chemistry (2016), 14(4), 1413-1420, database is CAplus and MEDLINE.

3-Iodo-4-(2′-methylcyclohexyloxy)-6-phenethylpyridin-2(1H)-ones, as effective non-nucleoside reverse transcriptase inhibitors, were synthesized and resolved with different configurations. Biol. results revealed that the trans-racemate exhibited more potent activity than the cis-isomers. Noticeably, the trans-(S,S)-enantiomer turned out to be significantly more potent than its counterpart enantiomer against wild-type and double-mutant strains with high selectivity indexes.

Organic & Biomolecular Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C11H9NO3, HPLC of Formula: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hasegawa, Futoshi published the artcileHighly Efficient Syntheses of C-N Axially Chiral 1-(ortho-hydroxyaryl)uracil using a Chiral Auxiliary and a Chiral Base, SDS of cas: 21286-54-4, the publication is Asian Journal of Organic Chemistry (2018), 7(8), 1648-1653, database is CAplus.

A highly diastereoselective synthesis of 1-aryl-6-aminouracils, which were C-N atropisomeric compounds, through the combined use of a chiral auxiliary and a chiral base under mild conditions was achieved. The (R)-5-allyl-2-oxabicyclo[3.3.0]oct-1-yl group was a good chiral auxiliary that, when combined with quinidine, efficiently afforded 1-aryl-6-aminouracils with high diastereoselectivity (up to 98 % ee after isolation). The chiral alc. moiety in quinidine appeared to be crucial for achieving stereoselectivity during cyclization. Furthermore, the chiral auxiliary was easily removed from the product under acidic conditions to provide the atropisomer with high enantiomeric excess (up to 96 % ee). The developed method was an efficient diastereoselective-cyclization method for the generation of C-N axial chirality.

Asian Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, SDS of cas: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Wenwen published the artcileMicrodroplets as Microreactors for Fast Synthesis of Ketoximes and Amides, Related Products of chlorides-buliding-blocks, the publication is Journal of Organic Chemistry (2019), 84(2), 851-859, database is CAplus and MEDLINE.

The formation of amide bonds is one of the most valuable transformations in organic synthesis. Beckmann rearrangement is a well-known method for producing secondary amides from ketoximes. This study demonstrates the rapid synthesis of ketoximes and amides in microdroplets. Many factors are found to affect the yield, such as microdroplet generation devices, temperature, catalysts, and concentrations of reactants. In particular, the temperature has a great influence on the synthesis of amide, which is demonstrated by a sharp ascendance to the yield when the temperature was increased to 45°. The best amide yield (93.3%) can be obtained by using coaxial flowing devices, a sulfonyl chloride compound as a catalyst, and heating to 55° in microdroplets. The yields can reach 78.7-91.3% for benzoylaniline and 87.2-93.4% for benzophenone oximes in several seconds in microdroplets compared to 10.1-66.1% and 82.5-93.3% in several hours in the bulk phase. Apart from the dramatically decreased reaction time and enhanced reaction yields, the microdroplet synthesis is also free of severe reaction environments (anhydrous and anaerobic conditions). In addition, the synthesis in microdroplets also saves reactants and solvents and reduces the waste amounts All of these merits indicate that the microdroplet synthesis is a high-efficiency green methodol.

Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C11H15NOS, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kou, Wen-Ting published the artcilePost-synthetic modification of metal-organic frameworks for chiral gas chromatography, Name: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2018), 6(37), 17861-17866, database is CAplus.

Chiral metal-organic frameworks (MOFs) show great potential in chiral catalysis and separation However, their application is still hindered by the limited availability of chiral MOFs and chiral recognition centers due to the great challenges for direct synthesis of chiral MOFs with designed chiral recognition sites. Here we report a post-synthesis approach for the facile preparation of chiral MOFs for chiral gas chromatog. Five chiral MOFs with an identical parent framework but different chiral recognition sites were synthesized via grafting various chiral recognition sites of ligands onto MIL-101-NH₂. The chiral MOF-coated capillary columns gave good resolution for the separation of diverse racemates with superior separation to the com. chiral capillary columns. The results reveal that the post-synthesis approach is convenient to fabricate target chiral MOFs with pre-designed functions with the ability to avoid blind synthesis of chiral MOFs via direct synthesis and to facilitate the evolution of chiral stationary phases in chiral chromatog.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Name: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics