Category: 21286-54-4

Xu, Ren-Rui published the artcilePalladium-catalyzed cascade Heck-type cyclization and reductive aminocarbonylation for the synthesis of functionalized amides, Related Products of chlorides-buliding-blocks, the publication is Organic & Biomolecular Chemistry (2022), 20(13), 2605-2608, database is CAplus and MEDLINE.

A palladium-catalyzed Heck/carbonylative cyclization process was explored for the synthesis of functionalized amides. By using nitroarenes as readily accessible nitrogen sources, a variety of amide products, e.g., I (Ar = 4-MeC₆H₄, 2-ClC₆H₄, 1-naphthyl, 2-thienyl, 8-quinolinyl, etc.), was obtained from the corresponding o-iodoaryl alkenes, e.g., II, in moderate to excellent yields with good functional group compatibility. Furthermore, a late-stage modification of a natural mol. was also achieved by this protocol.

Organic & Biomolecular Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C13H14N2O, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ma, Hao published the artcileSynthesis of Bridging Chiral p-tert-Butylcalix[4]arenes with One and Two Carbamoyl Bridge-Substituents through Anionic Ortho-Fries Rearrangement, SDS of cas: 21286-54-4, the publication is ChemistrySelect (2020), 5(21), 6274-6277, database is CAplus.

Bridging chiral p-tert-butylcalix[4]arenes (p-t-Bu-BCC’s) with different N-substituted carbamoyl bridge-substituents (N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl and morpholinocarbonyl) were successfully prepared through anionic ortho-Fries rearrangement from mono-O-carbamates of 1,3-dipropyl-p-tert-butylcalix[4]arene in 65-75% yield. In addition, p-t-Bu-BCC with two N,N-dimethylcarbamoyl bridge-substituents was produced by this method from mono-O-carbamate of p-t-Bu-BCC with one N,N-dimethylcarbamoyl bridge-substituent in 71% yield. However, the synthesis of p-t-Bu-BCC with addnl. carbamoyl bridge-substituents using this method could not be attempted, as the required rearrangement precursor failed to be synthesized. Finally, the racemic p-t-Bu-BCC with morpholinocarbonyl bridge-substituent was optically resolved into a pair of enantiomers, whose absolute configurations were determined through ROESY anal. and ECD comparison.

ChemistrySelect published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, SDS of cas: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chevis, Philip J. published the artcileHighly diastereoselective synthesis of enantioenriched anti-α-allyl-β-fluoroamines, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(43), 6050-6053, database is CAplus and MEDLINE.

A highly diastereoselective synthesis of anti-α-allyl-β-fluoroamines was developed involving enantioselective α-fluorination of aldehydes followed by a diastereoselective Petasis allyl borono-Mannich reaction. The products are obtained generally in good overall yields for the two steps and with drs of 97 : 3-99 : 1 and ees of 86-92%. Selected products were converted to 3-, 5- and 6-membered ring heterocycles, the latter two types incorporating an exo-cyclic fluorine.

Chemical Communications (Cambridge, United Kingdom) published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fronk, Stephanie L. published the artcileEffect of chiral 2-ethylhexyl side chains on chiroptical properties of the narrow bandgap conjugated polymers PCPDTBT and PCDTPT, COA of Formula: C10H15ClO3S, the publication is Chemical Science (2016), 7(8), 5313-5321, database is CAplus and MEDLINE.

Two narrow bandgap conjugated polymers containing chiral 2-ethylhexyl side chains were synthesized: poly[(4,4-bis(2-ethylhexyl)cyclopenta-[2,1-b:3,4-b‘]dithiophene)-2,6-diyl-alt-(2,1,3-benzothiadiazole)-4,7-diyl] (PCPDTBT*) and poly[(4,4-bis(2-ethylhexyl)cyclopenta[2,1-b:3,4-b‘]dithiophene)-2,6-diyl-alt-[1,2,5]-thiadiazolo[3,4-c]pyridine] (PCDTPT*). The presence of a chiral substituent provides a handle to study the geometry of interchain aggregates and/or the secondary structure of these conjugated polymers in solution and in thin films via CD spectroscopy, provided that the asymmetry in the side-chain was translated to the optically active conjugated backbone. CD signals were observed for PCPDTBT* and PCDTPT* in poor solvent systems, which indicated the presence of chiral ordering in the aggregates. PCPDTBT* showed greater chiral order than PCDTPT* based on their relative anisotropy factors. Addnl., GIWAXS anal. reveals that PCPDTBT* films were more ordered than what was observed for the same polymer containing racemic 2-ethylhexyl chains. Upon solution deposition, the chiral ordering was found to translate to the solid-state microstructure for PCPDTBT* but not PCDTPT*. The presence of a pyridyl nitrogen on the thiadiazolo[3,4-c]pyridine ring of PCDTPT* favored a planar conformation for the backbone such that it has a higher rotational barrier compared to PCPDTBT*. This larger rotational barrier appeared to limit the ability of PCDTPT* to adopt a helical structure or relevant chain distortions for achieving chiral aggregates.

Chemical Science published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, COA of Formula: C10H15ClO3S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Huang, Benhua published the artcileSynthesis of mesoporous zirconium-containing silicates and their application for catalytic asymmetric addition of diethylzinc to aldehydes, Product Details of C10H15ClO3S, the publication is Journal of Porous Materials (2017), 24(4), 867-879, database is CAplus.

A series of mesoporous zirconium-containing silicates were prepared in sol-gel, which were further functionalized by chiral sulfonyl chloride and proline for catalytic asym. addition of diethylzinc to aldehydes. These materials had good porosities, hexagonal symmetries and internal chiralities. Moreover, significant morphol. variations were observed when preparative conditions were changed. These materials also showed good to excellent enantioselectivities in catalysis, and there was chiral induction synergy between silicate matrix and attached ligand. Recycling of catalyst was tested, and promising results were obtained. This study would contribute to the design of mesoporous chiral catalysts.

Journal of Porous Materials published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Product Details of C10H15ClO3S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Pengquan published the artcileAsymmetric Total Synthesis of Dankasterones A and B and Periconiastone A Through Radical Cyclization, Quality Control of 21286-54-4, the publication is Angewandte Chemie, International Edition (2021), 60(10), 5512-5518, database is CAplus and MEDLINE.

We describe herein the assembly of the cis-decalin framework through radical cyclization initiated by metal-catalyzed hydrogen atom transfer (MHAT), further applied it in the asym. synthesis of dankasterones A and B and periconiastone A. Position-selective C-H oxygenation allowed for installation of the necessary functionality. A radical rearrangement was adopted to create 13(14�)abeo-8-ergostane skeleton. Interconversion of dankasterone B and periconiastone A was realized through biomimetic intramol. aldol and retro-aldol reactions. The MHAT-based approach, serves as a new dissection means, is complementary to the conventional ways to establish cis-decalin framework.

Angewandte Chemie, International Edition published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Quality Control of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fronk, Stephanie L. published the artcileChiroptical Properties of a Benzotriazole-Thiophene Copolymer Bearing Chiral Ethylhexyl Side Chains, Synthetic Route of 21286-54-4, the publication is Macromolecules (Washington, DC, United States) (2016), 49(24), 9301-9308, database is CAplus.

Conjugated polymers containing alternating thiophene units and benzotriazole structural units bearing either chiral (S)-2-ethylhexyl (PBTz-Th*) or racemic 2-ethylhexyl side chains (PBTz-Th) were synthesized. Characterization by optical absorption spectroscopy of both PBTz-Th* and its racemic counterpart reveal aggregated chains, even at dilute concentrations in good solvents. The presence of a chiral substituent permits characterization via CD (CD) spectroscopy. CD spectra provide evidence of chiral aggregates of PBTz-Th* chains even at 0.01 mg/mL in dichlorobenzene. When PBTz-Th* solutions are diluted with PBTz-Th, the resulting CD spectrum suggests that PBTz-Th* chains are chiral in the aggregate. Chiral ordering is also found to translate from aggregates in solution to the solid state.

Macromolecules (Washington, DC, United States) published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Synthetic Route of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Laha, Joydev K. published the artcileDesign, Sustainable Synthesis, and Programmed Reactions of Templated N-Heteroaryl-Fused Vinyl Sultams, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Journal of Organic Chemistry (2017), 82(18), 9350-9359, database is CAplus and MEDLINE.

A de novo design and synthesis of N-heteroaryl-fused vinyl sultams as templates for programming chem. reactions on vinyl sultam periphery or (hetero)aryl ring is described. The key features include rational designing and sustainable synthesis of the template, customized reactions of vinyl sultams at C=C bond or involving N-S bond cleavage, and reactions on the periphery of the heteroaryl ring for late-stage diversification. The simple, easy access to the template coupled with opportunities for the synthesis of diversely functionalized heterocyles from a single template constitutes a rare study in contemporary organic synthesis.

Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bryant, Laura A. published the artcileEnantioselective Organocatalytic Synthesis of Bicyclic Resorcinols via an Intramolecular Friedel-Crafts-Type 1,4-Addition: Access to Cannabidiol Analogues, Category: chlorides-buliding-blocks, the publication is Advanced Synthesis & Catalysis (2021), 363(16), 4067-4074, database is CAplus and MEDLINE.

A highly enantioselective, organocatalytic intramol. cyclization by a Friedel-Crafts-type 1,4-addition using a Joergensen-Hayashi-like organocatalyst with a large silyl protecting group and showed that heat improved the reaction yield with virtually no detriment to enantioselectivity. A variety of bicyclic resorcinols were obtained with excellent enantioselectivities (up to 94%). To show the utility of these constructs, and as part of a wider project involved the synthesis of cannabinoid-like compounds, the resorcinol formed was used to generate both ‘normal’ and ‘abnormal’ cannabidiol which had anticonvulsant activity.

Advanced Synthesis & Catalysis published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Qiang-Qiang published the artcileDirect Wittig Olefination of Alcohols, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Journal of Organic Chemistry (2018), 83(1), 296-302, database is CAplus and MEDLINE.

Benzylic alcs. such as benzyl alc. underwent chemoselective and diastereoselective Wittig olefinations with alkyltriphenylphosphonium salts such as 2-pyridinylmethyltriphenylphosphonium chloride mediated by t-BuOK and air in THF to give aryl alkenes such as (E)-2-(2-phenylethenyl)pyridine in 8-93% yields and in ≥8:1 E:Z diastereoselectivities. Benzylic alcs. were thus directly transformed to olefins without pre-preparation of either aryl aldehydes or ylides. 1,2-Benzenedimethanol underwent chemoselective Wittig olefination to give mono- or dialkenylbenzenes; an unsym. dialkenylbenzene was also prepared The method was used to prepare the potential antitumor agent DMU-212, resveratrol, and nonracemic hexahelicenol enantiomers. The mechanism and kinetics of the olefination were studied.

Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics