Category: 21286-54-4

Wieting, Joshua M. published the artcilePreparation and catalytic activity of BINOL-derived silanediols, COA of Formula: C10H15ClO3S, the publication is European Journal of Organic Chemistry (2015), 2015(3), 525-533, database is CAplus.

Enantiopure silanediols I (2a–d; 2a, R¹ = R² = H; 2b, R¹ = R² = Ph; 2c, R¹ = H, R² = Ph; 2d, R¹ = Ph, R² = H) derived from BINOL are an innovative family of stereoselective hydrogen-bond donor (HBD) organocatalysts. Silanediols incorporated into a BINOL framework are attractive catalysts, as they are readily accessible and highly customizable. Structural modifications of the BINOL backbone affect the reactivity and selectivity of the silanediol catalysts in the additions of silyl ketene acetals to N-acyl isoquinolinium ions. The best results were obtained when the silanediol scaffold was substituted at the 4,4′- and 6,6′-positions. This report includes details regarding the properties of selected BINOL-based silanediol catalysts, including their acidities, binding constants, and x-ray crystal structures.

European Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C22H21N3O3S, COA of Formula: C10H15ClO3S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Huang, Benhua published the artcileSol-gel preparation of helical silicate containing palladium oxide nanoparticles and the application for nitration of aromatic compound, Formula: C10H15ClO3S, the publication is Molecular Catalysis (2018), 140-151, database is CAplus.

Two palladium-containing silicates are prepared through sol-gel, and doping of L-sodium lactate plays a key role for giving helical morphol. The helical silicate is modified by chiral sulfonyl chloride in order to modulate coordination environment of palladium for enhanced catalysis. The porosity, composition, crystalline nature and bulk chirality have been studied too. All synthetic silicates show high yields for nitration of arenes by using available nitro-source. Both solvent acidity and oxidant seem crucial to nitration more than others. The conversion of larger arene is related to catalyst porosity, and modification of silicate with chiral sulfonyl chloride shows varied results. Furthermore, two catalysts exhibit renewable recycling behaviors, proving their interior palladium could be utilized. Lastly, a tetravalent palladium-facilitated mechanism is proposed. This work may contribute to the design and catalytic application of nanosized or microsized silica material with particular morphol.

Molecular Catalysis published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Formula: C10H15ClO3S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pedersen, Stephan K. published the artcileSymmetric, Unsymmetrical, and Asymmetric [7]-, [10]-, and [13]Helicenes, Category: chlorides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2019), 58(51), 18419-18423, database is CAplus and MEDLINE.

Fully aromatic helicenes with more than one pitch-length are illustrious synthetic targets with potential applications in advanced optical devices and nano-electronics. The task of extending the length of fully conjugated helicenes past one pitch length is challenging. Now, the synthesis of a series of azaoxa[7]-, [10]-, and [13]helicenes is described. The synthesis is based on iterative oxidative furan formation between 3,6-dihydroxycarbazoles and/or 2-naphthols [e.g., oxidative coupling of carbazole I to II followed by selective protection of least sterically hindered alcs. and furan formation mediated by oxidant and Lewis acid afforded diazaoxa[7]helicene III]. The flexibility of the presented method allows the convenient and scalable synthesis of sym., unsym., and asym. homo-chiral structures. The [13]helicenes can be synthetically functionalized both at the termini and the periphery. The full range of helicenes were characterized using NMR and optical spectroscopy (UV/Vis, fluorescence, and CD) along with single-crystal X-ray crystallog. The enantiomers of the [13]helicenes are the longest optically pure helicenes isolated to date.

Angewandte Chemie, International Edition published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Munkuev, Aldar A. published the artcileAdamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan, Formula: C10H15ClO3S, the publication is Molecules (2022), 27(11), 3374, database is CAplus and MEDLINE.

Inhibiting tyrosyl-DNA phosphodiesterase 1 (TDP1) is a promising strategy for increasing the effectiveness of existing antitumor therapy since it can remove the DNA lesions caused by anticancer drugs, which form covalent complexes with topoisomerase 1 (TOP1). Here, new adamantane-monoterpene conjugates with a 1,2,4-triazole or 1,3,4-thiadiazole linker core were synthesized, where (+)-and (-)-campholenic and (+)-camphor derivatives were used as monoterpene fragments. The campholenic derivatives showed activity against TDP1 at a low micromolar range with IC₅₀ ~5-6μM, whereas camphor-containing compounds were ineffective. Surprisingly, all the compounds synthesized demonstrated a clear synergy with topotecan, a TOP1 poison, regardless of their ability to inhibit TDP1. These findings imply that different pathways of enhancing topotecan toxicity other than the inhibition of TDP1 can be realized.

Molecules published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Formula: C10H15ClO3S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Uvarov, Vladimir M. published the artcileFirst study of rhodium(I) complexes with chiral sulfur-containing terpenoids as catalytic systems for ketone hydrosilylation, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2020), 195(5), 376-387, database is CAplus.

Using a “chiral pool” approach, a number of chiral thiolate and sulfide ligands based on natural terpenes and terpenoids have been synthesized in a few simple steps. Two new Rh-thiolate complexes with the formula [Rh(CO)₂(μ-SR)]₂ were obtained. The influence of these complexes and catalytic systems formed by combining the synthesized ligands with [Rh(CO)₂(μ-Cl)]₂ and [Rh(cod)(μ-Cl)]₂, on the reaction rate, chemoselectivity, stereoselectivity and formation of tetraphenyldisiloxane in Rh-catalyzed asym. hydrosilylation of acetophenone as a model reaction have been studied. Mechanistic aspects of formation of silyl enol ether as a side product in the presence of S-containing ligands are presented.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C9H6N2O2, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Harmse, Rozanne published the artcileActivities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Asexual and Transmissible Malaria Parasites, Related Products of chlorides-buliding-blocks, the publication is ChemMedChem (2017), 12(24), 2086-2093, database is CAplus and MEDLINE.

Dihydroartemisinin (DHA), either used in its own right or as the active drug generated in vivo from the other artemisinins in current clin. use-artemether and artesunate-induces quiescence in ring-stage parasites of Plasmodium falciparum (Pf). This induction of quiescence is linked to artemisinin resistance. Thus, we have turned to structurally disparate artemisinins that are incapable of providing DHA on metabolism Accordingly, 11-azaartemisinin 5 and selected N-sulfonyl derivatives were screened against intraerythrocytic asexual stages of drug-sensitive Pf NF54 and drug-resistant K1 and W2 parasites. Most displayed appreciable activities against all three strains, with IC₅₀ values <10.5 nM. The p-trifluoromethylbenzenesulfonyl-11-azaartemisinin derivative 11 [(4′-trifluoromethyl)benzenesulfonylazaartemisinin] was the most active, with IC₅₀ values between 2 and 3 nM. The compounds were screened against Pf NF54 early and transmissible late intraerythrocytic-stage gametocytes using luciferase and parasite lactate dehydrogenase (pLDH) assays. The 2′-thienylsulfonyl derivative 16 (2′-thiophenesulfonylazaartemisinin) was notably active against late-stage (IV-V) gametocytes with an IC₅₀ value of 8.7 nm. All compounds were relatively nontoxic to human fetal lung WI-38 fibroblasts, showing selectivity indexes of >2000 toward asexual parasites. Overall, the readily accessible 11-azaartemisinin 5 and the sulfonyl derivatives 11 and 16 represent potential candidates for further development, in particular for transmission blocking of artemisinin-resistant parasites.

ChemMedChem published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lin, Shuangjie published the artcileVisible-light-driven spirocyclization of epoxides via dual titanocene and photoredox catalysis, HPLC of Formula: 21286-54-4, the publication is Chemical Science (2020), 11(3), 839-844, database is CAplus and MEDLINE.

The synergistic utilization of titanocene/photoredox dual catalysis driven by visible light for the radical opening/spirocyclization of easily accessible epoxyalkynes. This environmentally benign process used organic donor-acceptor fluorophore 2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile as a photocatalyst and Hantzsch ester as an electron donor instead of stoichiometric metallic reductants. The photocatalytic conditions showed exceptionally high reactivity for the synthesis of privileged and synthetically challenging spirocycles, e.g., I, featuring a spiro all-carbon quaternary stereocenter. Cyclic voltammetry studies suggest that Cp₂TiIIICl is the catalytically active species.

Chemical Science published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, HPLC of Formula: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Xiaoguang published the artcileCopper-Catalyzed γ-Sulfonylation of α,β-Unsaturated Carbonyl Compounds by Means of Silyl Dienol Ethers, Computed Properties of 21286-54-4, the publication is Organic Letters (2015), 17(14), 3572-3575, database is CAplus and MEDLINE.

γ-Sulfonyl-α,β-unsaturated ketones such as I [R = Ph, 4-MeC₆H₄, 4-O₂NC₆H₄, 2,4,6-R¹₃C₆H₂, F₅C₆, 8-quinolinyl, Me, i-Pr, ClCH₂CH₂, cyclopropyl, (1S)-10-camphorsulfonyl; R¹ = Me, i-Pr; R² = H] were prepared regioselectively by reaction of dienyl silyl ethers such as II (TBDMS = tert-butyldimethylsilyl) with sulfonyl chlorides RSO₂Cl [R = Ph, 4-MeC₆H₄, 4-O₂NC₆H₄, 2,4,6-R¹₃C₆H₂, F₅C₆, 8-quinolinyl, Me, i-Pr, ClCH₂CH₂, cyclopropyl, (1S)-10-camphorsulfonyl; R¹ = Me, i-Pr] in the presence of CuCl in MeCN. Selected sulfonylated unsaturated ketones underwent regioselective alkylation and Michael addition reactions and cyclocondensations to yield products such as I (R = Ph; R² = Me, MeO₂CCH₂CH₂).

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Computed Properties of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yuan, Tianqi published the artcileSynthesis of camphor sulfonic acid derivatives modified Mg/Al-LDH for efficient separation of propranolol enantiomers, HPLC of Formula: 21286-54-4, the publication is Applied Clay Science (2022), 106521, database is CAplus.

Designing chiral adsorption separation material with high enantioselectivity and stability is a promising route to realize the enantioselective recognition and separation of racemic mols. Here, for the first time, camphor sulfonic acid derivatives (CSA) were synthesized as a chiral resolving agent, and it was modified on Mg/Al layered double hydroxide (Mg/Al-LDH) through electrostatic self-assembly to construct functionalized chiral adsorption separation material (CSA@LDH), which could be served as an adsorbent for enantioselective recognition and separation of propranolol enantiomers (R,S-PRO). The CSA@LDH maintained the advantage of limited chiral space in layered structures to achieve the selective enrichment of R-PRO, and the e.e.% value of single separation could reach 19.5%. Meanwhile, d. functional theory (DFT) calculations supported that chiral recognition and separation were ascribed to the discrepancy in affinities stemming from the difference of π-π interaction force and hydrogen bonding capacity of CSA with R,S-PRO. Hence, considering the superior ability of hydrogen bond coordination and stereocontrol of camphor sulfonic acid derivatives, it is expected to be more widely used as a chiral resolving agent for other enantiomeric recognition and separation

Applied Clay Science published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C5H5BO5, HPLC of Formula: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abrams, Rachel P. published the artcileFive-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells, Formula: C10H15ClO3S, the publication is ACS Chemical Biology (2016), 11(5), 1305-1312, database is CAplus and MEDLINE.

A 1,2-dioxolane (FINO₂) was identified as a lead compound from a screen of organic peroxides. FINO₂ does not induce apoptosis, but instead initiates ferroptosis, an iron-dependent, oxidative cell death pathway. Few compounds are known to induce primarily ferroptosis. In contrast to the perceived instability of peroxides, FINO₂ was found to be thermally stable to at least 150 °C. FINO₂ was more potent in cancer cells than nonmalignant cells of the same type. One of the enantiomers was found to be more responsible for the observed activity.

ACS Chemical Biology published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Formula: C10H15ClO3S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics