Category: 21402-26-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21402-26-6, name is 4-Bromo-3-chloroaniline, A new synthetic method of this compound is introduced below., category: chlorides-buliding-blocks

The product from example 32 step (ii) (O. 5g) and 4-bromo-3-chloroaniline (0. 38G) were dissolved in toluene (4ML). Ethanol (LML), 2M aqueous sodium carbonate (LML) and PD (PPh3) 4 (0. 115G) were added sequentially and the mixture heated at reflux for 4h. The reaction was cooled, evaporated, dissolved in EtOAc, washed with water and brine, dried (MGS04) and evaporated. The residue was purified by chromatography on silica eluting with 10% EtOAc/isohexane. Yield 0.23g. 1H NMR DMSO-d6 : 8 7.67 (ddd, 1H), 7.4 (d, 1H), 7.27-7. 34 (m, 6H), 7.01 (d, 1H), 6.7 (d, 1H), 6.55 (dd, 1H), 5.47 (s, 2H) 5.18 (s, 2H)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ASTRAZENECA AB; WO2004/89885; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 21402-26-6, name is 4-Bromo-3-chloroaniline, This compound has unique chemical properties. The synthetic route is as follows., Formula: C6H5BrClN

EXAMPLE 53 9-(Trifluoromethyl)-1,2,3,6-tetrahydro-7H-[1,4]thiazino[3,2-g]quinolin-7-one (Compound 156, Structure 54 of Scheme XI, where R4=H) 6-Bromo-7-chloro-2-isopropoxy-4-(trifluoromethyl)quinoline (Structure 51 of Scheme XI). This compound was prepared according to General Method 11 (EXAMPLE 22) from 4-bromo-3-chloroaniline (2.06 g, 10.0 mmol), ethyl 4,4,4-trifluoroacetoacetate (2.30 g, 12.5 mmol) in 50 mL toluene followed by heating in 33 mL conc. H2SO4 to afford 2.08 g (64%) of 6-bromo-7-chloro-4-(trifluoromethyl)-quinolin-2(1H)-one, an off-white solid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 21402-26-6.

Reference:
Patent; Ligand Pharmaceuticals, Inc.; US6462038; (2002); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 21402-26-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21402-26-6, name is 4-Bromo-3-chloroaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 1 Preparation of N,N-Dipentyl-4-bromo-3-chloroaniline (1). 1-Bromopentane (0.42 mL, 3.4 mmol) was added to a mixture of 4-bromo-3-chloroaniline (200 mg, 0.9 mmol) and potassium carbonate (199 mg, 1.4 mmol) in DMF (20 mL) and the reaction was heated to 13 0~~C overnight. The mixture was cooled, diluted with water (20 mL) and extracted with petroleum ether (3*25mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified via flash column chromatography using 9:1 petroleum ether:ethyl acetate as eluent to give N,N-Dipentyl-4-bromo-3-chloroaniline (1) (332 mg, 68%). 1H-NMR (CDCI3) 67.02 (d, IH, ArH); 3.12 (t, 4H, 2*NCH2); 0.95 (t, 6H, 2*CH3). MS; 347 (M+H).

The synthetic route of 4-Bromo-3-chloroaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Oxford Glycosciences (UK) Ltd.; US6262263; (2001); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics