Category: 2162-98-3

Synthetic Route of 2162-98-3,Some common heterocyclic compound, 2162-98-3, name is 1,10-Dichlorodecane, molecular formula is C10H20Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 8 20.6 g (0.1 mol) of 4-octylaminopyridine, 10.5 g (0.05 mol) of 1,10-dichlorodecane and 30 ml of white spirit (boiling point 155 to 200 C.) were combined and heated to 130 C. The exothermic reaction causes the temperature to increase to 155 C., and at the same time white crystal precipitate out. The reaction mixture was stirred for a further 4 hours at 140 C., and after cooling to room temperature the very fine crystal sludge was filtered over a filterpaper and washed with petroleum ether, giving a beige, solid mass. The reaction product octenidine dihydrochloride in this example is very difficult to filter off with suction since it is produced in very fine form.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,10-Dichlorodecane, its application will become more common.

Reference:
Patent; AIR LIQUIDE SANTE (INTERNATIONAL); US2001/16660; (2001); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 2162-98-3,Some common heterocyclic compound, 2162-98-3, name is 1,10-Dichlorodecane, molecular formula is C10H20Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 8 20.6 g (0.1 mol) of 4-octylaminopyridine, 10.5 g (0.05 mol) of 1,10-dichlorodecane and 30 ml of white spirit (boiling point 155 to 200 C.) were combined and heated to 130 C. The exothermic reaction causes the temperature to increase to 155 C., and at the same time white crystal precipitate out. The reaction mixture was stirred for a further 4 hours at 140 C., and after cooling to room temperature the very fine crystal sludge was filtered over a filterpaper and washed with petroleum ether, giving a beige, solid mass. The reaction product octenidine dihydrochloride in this example is very difficult to filter off with suction since it is produced in very fine form.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,10-Dichlorodecane, its application will become more common.

Reference:
Patent; AIR LIQUIDE SANTE (INTERNATIONAL); US2001/16660; (2001); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2162-98-3, name is 1,10-Dichlorodecane, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1,10-Dichlorodecane

Reaction product of N,N-dimethylaminoethanol and 1 ,10-dichlorodecane (AE- DCD) [0089] N,N-dimethylaminoethanol (4.216 g, 0.047 mol) was added to a single neck round bottom flask. The flask was then fitted with a drying tube and stirred using a magnetic stirrer. 1,10-dichlorodecane (5 mL, 0.024 mol) was added slowly through a syringe to control the exothermic mixing. After completing the addition the reaction mixture was stirred under ambient conditions for 30 minutes. It was then immersed in a preheated oil bath maintained at 80 C. The contents of the flask solidified after heating for 4 h. The solid was washed with diethyl ether and dried in a vacuum oven. Yield: 6 g. 1H-NMR analysis indicated that the -CH3 group attached to the N atom shifted to 3.3 ppm after quaternization.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2162-98-3.

Reference:
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; ANBANANDAM, Parthiban; (53 pag.)WO2016/148649; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 2162-98-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2162-98-3, name is 1,10-Dichlorodecane belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine (0.45 g, 2.44 mmol), 1,10-dichlorodecane (0.25 g, 1.2mmol), and sulfolane (2 mL) was heated at 190-200 C for 90 h. The resulting mass was stirred with methanol and filtered. The filtrate was concentrated and chromatographedon an Al2O3 column using a gradient from 1 to 25% ofmethanol in methylene chloride. Fractions containing required product were pooled together and evaporated, andthe resulting off-white solid (31 mg, 4.5%) was further purified by crystallization from a methanol/acetone mixture [Mp 250-258 C (dec). 1H NMR (500 MHz, CDCl3) delta1.27-1.43 (m, 12 H), 1.67-1.76 (m, 4 H), 2.20-2.26 (m, 4H), 2.95 (t, 4 H, J = 7.5 Hz), 3.38 (t, 4 H, J = 7.5 Hz), 3.63(t, 4 H, J = 7.0 Hz), 4.46 (t, 4 H, J = 6.5 Hz),7.72 (t, 2 H, J = 7.0 Hz), 7.98 (t, 2 H, J = 7.5 Hz),8.15 (d, 2 H, J = 9.0 Hz), 8.54 (d with fine splitting, 2 H,J = 8.5 Hz), 8.92 (br s, 4 H, NH2).

The synthetic route of 1,10-Dichlorodecane has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sharma, Arun K.; Krzeminski, Jacek; Weissig, Volkmar; Hegarty, John P.; Stewart, David B.; Journal of Antibiotics; vol. 71; 8; (2018); p. 713 – 721;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 2162-98-3,Some common heterocyclic compound, 2162-98-3, name is 1,10-Dichlorodecane, molecular formula is C10H20Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,10-Dichlorodecane (8.73 g, 41.3 mmol) and triethylamine (6 mE) were added to a solution of m-aminophenol (3.85 g, 35.3 mmol) in DMF (40 mE). The mixture was stirred at 1000 C. for 3 days. The reaction was quenched with sam- 40 rated aqueous NaHCO3 and extracted with EtOAc. The combined organic layer was washed with brine, dried over anhydrous MgSO4, filtered, and concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, hexane_EtOAc=9:i to 1:1) to give the title compound (1.92 g, 6.76 mmol, 19% yield). Brown oil; R1=0.57 (33% EtOAc-hexane); ?H NMR (600 MHz, DM50- d5) oe 8.84 (s, 1H), 6.80 (dd, J=7.6, 8.3 Hz, 1H), 5.97 (d, J=7.6 Hz, 1H), 5.94 (s, 1H), 5.92 (d, J=8.2 Hz, 1H), 5.36 (s, 1H), 50 3.61 (m, 2H), 2.89 (m, 2H), 1.69 (m, 2H), 1.49 (m, 2H),1.35-1.25 (m, 12H); ?3C NMR (150 MHz, DMSO-d5) oe158.3, 150.6, 129.5, 103.7, 103.0,98.9,45.6,43.1,32.2,29.2,29.1 x2, 28.9,28.4,26.9,26.4; FABMS m/z 283 [M]; HRMS calcd. for C,6H26N0C1 [M] 283.1703. found 283.1708. 55theoil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,10-Dichlorodecane, its application will become more common.

Reference:
Patent; KYOTO UNIVERSITY; Uesugi, Motonari; Hirata, Nao; Murata, Asako; Chang, Young-Tae; Nakatsuji, Norio; Suemori, Hirofumi; Kawase, Eihachiro; Yamauchi, Kaori; Ueda, Kazumitsu; Fujibayashi, Yuto; Yamanaka, Shinya; Nakagawa, Masato; (34 pag.)US9335323; (2016); B2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 2162-98-3, These common heterocyclic compound, 2162-98-3, name is 1,10-Dichlorodecane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5.68 g (0.05 M) of 4-chloropyridine was dissolved in 50 mL of dimethylformamide, and 15.63 g (0.025 M) of 1,10-dichlorodecane was separately dissolved in 170 mL of dimethylformamide. The 4-chloropyridine solution And the reflux reaction was carried out at 150 DEG C for 20 hours while slowly dropping at 100 DEG CWhen the thin layer chromatography phase reaction is completed, the reaction is stopped by adding about 20 mL of boiling water while cooling the reaction solution. The resulting solution is cooled to 0 C, made alkaline with 35% sodium hydroxide solution and extracted with dichloromethane doThe organic layer was washed with water and then magnesium sulfate was added to remove the water. The solution was distilled under reduced pressure to remove the solvent. 10.53 g of bis (4-chloropyridin-1 (4H) (Yield: 57.0%)

Statistics shows that 1,10-Dichlorodecane is playing an increasingly important role. we look forward to future research findings about 2162-98-3.

Reference:
Patent; Firson Co.,Ltd; Kim, Dong Jin; Koo, Chang Hwei; Park, Sung Yong; Cho, Ir Hwe; Lee, Sung Bae; Han, Dong Hoon; (12 pag.)KR2017/13425; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 2162-98-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2162-98-3, name is 1,10-Dichlorodecane belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 4-aminopyridine (1.5 g, 15.9 mmol) and 1,10-dichlorodecane (1.61 g, 7.95 mmol) in amyl alcohol (26mL) was stirred and refluxed under N2 for 21 h. After cooling to room temperature, white precipitate formed was filtered off and washed with acetone/water to yield 2.4 h(75%) of APDE-8, which was further purified by crystallization from ethanol [Mp 278-282 C. 1H NMR (500 MHz,DMSO-d6) delta 1.17-1.26 (m, 12 H), 1.70-1.75 (m, 4 H),4.10 (t, 4 H, J = 6.0 Hz), 6.87 (d, 4 H, J = 6.5 Hz), 8.20 (d,4H, J = 6.0 Hz), 8.23 (s, 4 H, NH2). MS m/z 327.1565(M-2Cl)+].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,10-Dichlorodecane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sharma, Arun K.; Krzeminski, Jacek; Weissig, Volkmar; Hegarty, John P.; Stewart, David B.; Journal of Antibiotics; vol. 71; 8; (2018); p. 713 – 721;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 2162-98-3, name is 1,10-Dichlorodecane, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2162-98-3, Product Details of 2162-98-3

Example 1 20.6 g (0.1 mol) of 4-octylaminopyridine, 10.5 g (0.05 mol) of 1,10-dichlorodecane and 30 ml of demineralized water were combined and refluxed with stirring. The initially cloudy, yellowish solution became clear and yellow after 3 hours. After the mass had been stirred for a further hour at reflux, it was cooled to 5 C. The resulting white, semisolid paste was filtered off with suction, and the product octenidine dihydrochloride in the form of colourless crystals was washed with iced water.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,10-Dichlorodecane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AIR LIQUIDE SANTE (INTERNATIONAL); US2001/16660; (2001); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics