Category: 22717-55-1

Farran, Daniel; Bertrand, Philippe published the artcile< Hammett constants effects in microwave cascade etherification-cyclization-Krapcho reaction to access [2,3]-dihydrobenzofuran-3-ones from salicylic derivatives>, Product Details of C8H7ClO3, the main research area is salicylate bromopropionate etherification cyclization Krapcho cascade microwave Hammett constant; hydrobenzofuranone preparation.

Two methods were evaluated for the synthesis of substituted 2,3-dihydro-2-methylbenzofuran-3-ones from the corresponding salicylate esters under microwave irradiation A 2-step sequence via ether intermediates was convenient for various substituted salicylate derivatives, while the 2nd strategy involving a 1-pot procedure was efficient for electron-donating substituted salicylates. Results allowed correlation of the Hammett constants effects in the intramol. cyclization of O-ethoxycarbonyl ethers of salicylic esters.

Synthetic Communications published new progress about Aromatic hydroxycarboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent) (esters). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Product Details of C8H7ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yuan, Tao; Zheng, Meifang; Antonietti, Markus; Wang, Xinchen published the artcile< Ceramic boron carbonitrides for unlocking organic halides with visible light>, Category: chlorides-buliding-blocks, the main research area is boron carbonitride preparation surface structure; aryl halide boron carbonitride photocatalyst hydrodehalogenation; aromatic hydrocarbon preparation; arene aryl halide boron carbonitride photocatalyst cross coupling arylation; biaryl preparation; haloarene sodium sulfinate boron carbonitride photocatalyst cross coupling sulfonylation; arylsulfone preparation.

Here, boron carbonitride (BCN) ceramics were such a system and can reduce organic halides, including (het)aryl and alkyl halides, with visible light irradn was reported. Cross-coupling of halides to afford new C-H, C-C, and C-S bonds was proceeded at ambient reaction conditions. Hydrogen, (het)aryl, and sulfonyl groups were introduced into the arenes and heteroarenes at the designed positions by means of mesolytic C-X (carbon-halogen) bond cleavage in the absence of any metal-based catalysts or ligands. BCN was used not only for half reactions, like reduction reactions with a sacrificial agent, but also redox reactions through oxidative and reductive interfacial electron transfer. The BCN photocatalyst showed tolerance to different substituents and conserved activity after five recycles. The apparent metal-free system opened new opportunities for a wide range of organic catalysts using light energy and sustainable materials, which were metal-free, inexpensive and stable.

Chemical Science published new progress about Aromatic compounds, sulfones Role: SPN (Synthetic Preparation), PREP (Preparation). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tykvart, Jan; Schimer, Jiri; Barinkova, Jitka; Pachl, Petr; Postova-Slavetinska, Lenka; Majer, Pavel; Konvalinka, Jan; Sacha, Pavel published the artcile< Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery>, SDS of cas: 22717-55-1, the main research area is glutamate carboxypeptidase II inhibitor prostate cancer targeting; GCPII; PSMA; Specific drug targeting; Structure-aided drug design.

Glutamate carboxypeptidase II (GCPII), also known as prostate specific membrane antigen (PSMA), is an established prostate cancer marker and is considered a promising target for specific anticancer drug delivery. Low-mol.-weight inhibitors of GCPII are advantageous specific ligands for this purpose. However, they must be modified with a linker to enable connection of the ligand with an imaging mol., anticancer drug, and/or nanocarrier. Here, we describe a structure-activity relationship (SAR) study of GCPII inhibitors with linkers suitable for imaging and drug delivery. Structure-assisted inhibitor design and targeting of a specific GCPII exosite resulted in a 7-fold improvement in Ki value compared to the parent structure. X-ray structural anal. of the inhibitor series led to the identification of several inhibitor binding modes. We also optimized the length of the inhibitor linker for effective attachment to a biotin-binding mol. and showed that the optimized inhibitor could be used to target nanoparticles to cells expressing GCPII.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, SDS of cas: 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Box, Vernon G. S.; Meleties, Panayiotis C. published the artcile< The thermal [3,3] Claisen rearrangement of the 3-substituted phenyl allyl and propargyl ethers. The synthesis of 4-halobenzo[b]furans>, Computed Properties of 22717-55-1, the main research area is Claisen rearrangement allyl phenyl ether regioselectivity mechanism; propargyl phenyl ether Claisen rearrangement regioselectivity mechanism.

The thermal [3,3] Claisen rearrangement of 3-substituted Ph allyl and propargyl ethers is regioselective. The major product of the reaction incorporates a 1,2,3-trisubstituted benzene ring. The 2-allenylphenol intermediates can be manipulated into the preparation of 4-substituted benzo[b]furans. The observed regioselectivity supports the biradicaloid mechanism of the Claisen rearrangement.

Heterocycles published new progress about Aromatic ethers Role: RCT (Reactant), RACT (Reactant or Reagent). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Computed Properties of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Deguchi, Toru; Xin, Hai-Long; Morimoto, Hiroyuki; Ohshima, Takashi published the artcile< Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides>, Application In Synthesis of 22717-55-1, the main research area is nickel catalyzed alcoholysis unactivated aminoquinoline amide.

Direct catalytic alcoholysis of unactivated amides is one of the most difficult challenges in organic chem., and an applicable method for cleaving amides used as directing groups in regioselective functionalization reactions has not been reported. Herein, authors report direct catalytic alcoholysis of 8-aminoquinoline amides, which are highly effective directing groups in regioselective functionalization reactions. The reactions proceeded with a simple combination of substrates, air-stable catalysts, and alcs., affording the corresponding esters in good yields with broad functional group tolerance. Highly chemoselective cleavage of the 8-aminoquinoline amides in the presence of related carbonyl functionalities and preliminary mechanistic studies are also described.

ACS Catalysis published new progress about Alcoholysis. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Application In Synthesis of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nakazato, Atsuro; Ohta, Kohmei; Sekiguchi, Yoshinori; Okuyama, Shigeru; Chaki, Shigeyuki; Kawashima, Yutaka; Hatayama, Katsuo published the artcile< Design, synthesis, structure-activity relationships, and biological characterization of novel arylalkoxyphenylalkylamine σ ligands as potential antipsychotic drugs>, Category: chlorides-buliding-blocks, the main research area is arylalkoxyphenylalkylamine preparation sigma ligand antipsychotic; structure activity arylalkoxyphenylalkylamine antipsychotic; sigma receptor antagonist arylalkoxyphenylalkylamine.

σ-Receptor antagonists may be effective antipsychotic drugs that do not induce motor side effects caused by ingestion of classical drugs such as haloperidol. The authors obtained evidence that 1-(2-dipropylaminoethyl)-4-methoxy-6H-dibenzo[b,d]pyran hydrochloride (I) had selective affinity for σ receptor over dopamine D2 receptor. This compound was designed to eliminate two bonds of apomorphine (II) to produce structural flexibility for the nitrogen atom and to bridge two benzene rings with a -CH2O- bond to maintain the planar structure. In light of the evidence, N,N-dipropyl-2-(4-methoxy-3-benzyloxyphenyl)ethylamine (III) was designed. Since compound III had eliminated a biphenyl bond of 6H-dibenzo[b,d]pyran derivative I, it might be more released from the rigid structure of apomorphine II than compound I. The chem. modification of compound III led to the discovery that N,N-dipropyl-2- [4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine hydrochloride (NE- 100), the best compound among arylalkoxyphenylalkylamine derivatives, had a high and selective affinity for σ receptor and had a potent activity in an animal model when the drug was given orally. The authors report here the design, synthesis, structure-activity relationships, and biol. characterization of novel arylalkoxyphenylalkylamine derivatives such as III.

Journal of Medicinal Chemistry published new progress about Antipsychotics. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gormemis, Ahmet E.; Ha, Tal Soo; Im, Isak; Jung, Kwan-Young; Lee, Ju Yeon; Park, Chul-Seung; Kim, Yong-Chul published the artcile< Benzofuroindole analogues as potent BKCa channel openers>, Recommanded Product: Methyl 4-chloro-2-hydroxybenzoate, the main research area is arylhydrazine benzofuranone condensation; arylhydrazone benzofuranone preparation Fischer cyclization acid catalyst; benzofuranone arylhydrazone preparation Fischer cyclization microwave irradiation acid catalyst; benzofuroindole preparation potassium channel opener; structure activity relationship benzofuroindole potassium channel opener.

New, potent, large-conductance, calcium-activated potassium-channel (BKCa) openers that show calcium-independent activation in electrophysiol. evaluations have been designed through optimizing the structure of the benzofuroindole skeleton by comparison with a known BKCa-channel opener (BMS-204352). A series of substituted benzofuroindoles I (R1 = H, Br; R2 = H, CF3, OCH3, Cl; R3 = H, COOH, COOCH3, Cl, OCH3, CF3; R4 = H, Cl, F; R5 = H, Cl, CF3; R6 = H, Cl, F, CF3) were prepared via sequence of reactions including as a key step either classical Fischer indole or microwave assisted cyclization of phenylhydrazones of benzofuranones. The BKCa-channel-opening activities of synthesized benzofuroindoles were studied. In particular, compound I (R1 = R4 = R5 = H; R2 = CF3; R3 = COOH, R6 = Cl) showed the most potent and effective activity in an intracellular calcium-independent manner. These new potassium channel openers might find therapeutic use to treat neuronal damage and be applied to therapeutic intervention in stroke, asthma, hypertension, convulsion, and traumatic brain injury.

ChemBioChem published new progress about Fischer indole synthesis. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Recommanded Product: Methyl 4-chloro-2-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fonte, Melanie; Fagundes, Natalia; Gomes, Ana; Ferraz, Ricardo; Prudencio, Cristina; Araujo, Maria Joao; Gomes, Paula; Teixeira, Catia published the artcile< Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials>, Application of C8H7ClO3, the main research area is diaminoacridine preparation antimalarial drug.

This is the first multi-step synthetic route, which has been developed towards N4,N9-disubstituted 4,9-diaminoacridines I. The target structures I are likely to reveal interesting biol. activities in the near future, not only due to their mepacrine-like core, but also because they embed simultaneously the pharmacophores of chloroquine and primaquine, antimalarial drugs that act at different stages of malaria infection.

Tetrahedron Letters published new progress about Acridines Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Application of C8H7ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chang, Chia-Lin published the artcile< Synthesis and structural pattern recognition of 5-(2'-alkoxycarbonyl-substituted phenoxy)furfural derivatives>, Computed Properties of 22717-55-1, the main research area is phenoxyfurfural phenoxyfurancarboxylate preparation structural recognition analysis NMR mass spectra; nitrofurfural phenol nucleophilic substitution.

The Et 5-(2′-alkoxycarbonyl-substituted phenoxy)furan-2-carboxylates e.g. I, showed good anti-platelet aggregation, anti-allergic and anti-inflammatory activities. A series of 5-(2′-alkoxycarbonyl-substituted phenoxy)furfurals e.g. II, were prepared for comparing the above activities. The objectives of this research are the synthesis and structural pattern recognition of 5-(2′-alkoxycarbonyl-substituted phenoxy)furfurals. The Silica Gel 60 column chromatog. method was employed to sep. and purify pure 5-(2′-alkoxycarbonyl-substituted phenoxy)furfurals, by three solvent systems. For the structure elucidation of 5-(2′-alkoxycarbonyl-substituted phenoxy)furfurals, four spectroscopic methods were used: electron impact mass (EI-MS), UV-VIS, IR and NMR spectrometers. With the help of spectrometers, investigations can be performed on spectroscopic data. A simple methodol. for recognizing structural patterns was carried out with the aid of statistical anal. designed to establish the classification model of the structural skeleton in this research. It was found that Et phenoxyfuran-2-carboxylate derivatives and phenoxyfurfural derivatives, have similar chem. profiles and are clustered into one group. The pattern plots revealed valuable information and showed good correlation between Et phenoxyfuran-2-carboxylate derivatives and phenoxyfurfural derivatives These findings correlate directly with the resulting spectroscopic data. These results with those obtained by EI-MS and NMR patterns give insight into a reliable pattern recognition for determining the skeletons of Et phenoxyfuran-2-carboxylate derivatives and phenoxyfurfural derivatives

Chemical & Pharmaceutical Bulletin published new progress about Electron ionization mass spectra. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Computed Properties of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Terakado, Masahiko; Suzuki, Hidehiro; Hashimura, Kazuya; Tanaka, Motoyuki; Ueda, Hideyuki; Kohno, Hiroshi; Fujimoto, Taku; Saga, Hiroshi; Nakade, Shinji; Habashita, Hiromu; Takaoka, Yoshikazu; Seko, Takuya published the artcile< Discovery of ONO-7300243 from a Novel Class of Lysophosphatidic Acid Receptor 1 Antagonists: From Hit to Lead>, Recommanded Product: Methyl 4-chloro-2-hydroxybenzoate, the main research area is ONO7300243 preparation lysophosphatidate receptor 1 antagonist drug discovery; GPCR; LPA1 antagonist; SAR; benign prostatic hyperplasia; hit-to-lead optimization.

Lysophosphatidic acid (LPA) evokes various physiol. responses through a series of G protein-coupled receptors known as LPA1-6. A high throughput screen against LPA1 gave compound 4′-{[(4-methoxybenzoyl)(3-phenylpropyl)amino]methyl}-2-biphenylcarboxylic acid (7a) as a hit. The subsequent optimization of 7a led to ONO-7300243 (17a) as a novel, potent LPA1 antagonist, which showed good efficacy in vivo. The oral dosing of 17a at 30 mg/kg led to reduced intraurethral pressure in rats. Notably, this compound was equal in potency to the α1 adrenoceptor antagonist tamsulosin, which is used in clin. practice to treat dysuria with benign prostatic hyperplasia (BPH). In contrast to tamsulosin, compound 17a had no impact on the mean blood pressure at this dose. These results suggest that LPA1 antagonists could be used to treat BPH without affecting the blood pressure. Herein, the authors report the hit-to-lead optimization of a unique series of LPA1 antagonists and their in vivo efficacy.

ACS Medicinal Chemistry Letters published new progress about Benign prostatic hyperplasia. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Recommanded Product: Methyl 4-chloro-2-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics