Category: 22717-55-1

Morris, Joel; Wishka, Donn G.; Fang, Yue published the artcile< A cyclodehydration route to 2-aminochromones>, Safety of Methyl 4-chloro-2-hydroxybenzoate, the main research area is salicylacetamide preparation cyclodehydration; cyclocondensation salicylacetamide; aminochromone; salicylate reaction amide enolate.

Cyclodehydration of salicylacetamides I with triflic anhydride efficiently provided the corresponding 2-aminochromone II (R1 = H, 6-, 7-, 8-MeO, 6-Br, 7-Cl, 7-, 8-Me; NR2 = NMe2, 4-morpholino) in 59-79% yield. The use of polyphosphoric ester (PPE) for this process was somewhat less effective. However, the deacylated derivative of compound II (R1 = AcNH, NR2 = 4-morpholino) was prepared in only 10% yield with triflic anhydride as reagent, whereas PPE as reagent afforded the expected compound II in 44% yield. Compounds I were prepared by reaction of substituted Me salicylates with an amide enolate.

Synthetic Communications published new progress about Cyclocondensation reaction. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Safety of Methyl 4-chloro-2-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chan, Pei Qie; Lee, Yean Kee; Abd Rahman, Noorsaadah published the artcile< Facile Intramolecular Cyclization of N-(2-Hydroxybenzoyl)hydrazones to N,N'-Diacetyl Benzo-1,3,4-oxadiazepine Derivatives>, Application In Synthesis of 22717-55-1, the main research area is diacetyl phenyl benzoxadiazepinone preparation; hydroxybenzoylhydrazone intramol cyclization sulfuric acid catalyst.

A facile synthesis of diacetyl-phenyl-benzoxadiazepinones I [R = Ph, 4-ClC6H3, 2-naphthyl, etc.; R1 = Ph, 4-MeSC6H4, 4-O2NC6H4, etc.] through sulfuric acid-catalyzed one-step intramol. cyclization of N-(2-hydroxybenzoyl)hydrazones was established and further the catalytic and substituent effects on the reactivity of this intramol. cyclization were investigated.

Asian Journal of Organic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Application In Synthesis of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Daqiang; Zhang, Xiaotuan; Ma, Xiaodong; Xu, Lei; Yu, Jianjun; Gao, Lixin; Hu, Xiaobei; Zhang, Jiankang; Dong, Xiaowu; Li, Jia; Liu, Tao; Zhou, Yubo; Hu, Yongzhou published the artcile< Development of macrocyclic peptides containing epoxyketone with oral availability as proteasome inhibitors>, Electric Literature of 22717-55-1, the main research area is macrocyclic peptide synthesis methylpyrazole imidazole pyrazole oral availability; pharmacokinetic structure activity 20S proteasome inhibition; amino acid coupling iodination alkenylation substitution reaction Stille coupling; peptide ring closing metathesis mol docking human 20S proteasome.

Macrocyclization has been frequently utilized for optimizing peptide or peptidomimetic-based compounds In an attempt to obtain potent, metabolically stable, and orally available proteasome inhibitors, 30 oprozomib-derived macrocyclic peptides with structural diversity in their N-terminus and linker were successively designed and synthesized for structure-activity relationship (SAR) studies. As a consequence, the macrocyclic peptides with N-methyl-pyrazole, imidazole, and pyrazole as their resp. N-termini exhibited favorable in vitro activity and metabolic stability, which translated into their potent in vivo proteasome inhibitory activity after oral administration. In particular, pyrazole-containing compound (I), as the most distinguished one among this series, displayed excellent chymotrypsin-like (ChT-L, β5) inhibitory potency (IC50 = 16 nM), low nanomolar antiproliferative activity against all three of the tested cell lines, and superior metabolic stability in mouse liver microsome (MLM), as well as favorable inhibition against ChT-L compared to that of oprozomib in BABL/c mice following administration at a comparatively low dose, thereby representing a promising candidate for further development.

Journal of Medicinal Chemistry published new progress about Alkenylation. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Electric Literature of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jolivalt, C.; Neuville, L.; Boyer, F. D.; Kerhoas, L.; Mougin, C. published the artcile< Identification and Formation Pathway of Laccase-Mediated Oxidation Products Formed from Hydroxyphenylureas>, Safety of Methyl 4-chloro-2-hydroxybenzoate, the main research area is laccase oxidation hydroxyphenylurea polyaromatic compound quinone.

Hydroxyphenylureas are the first main metabolites formed in the environment from pesticide and biocide urea compounds Because fungi release potent exocellular oxidases, we studied the ability of laccases produced by the white rot fungus, T. versicolor, to catalyze in vitro the transformation of five hydroxyphenylureas, to identify transformation pathways and mechanisms. Our results establish that the pH of the reaction has a strong influence on both the kinetics of the reaction and the nature of the transformation products. Structural characterization by spectroscopic methods (NMR, mass spectrometry) of eleven transformation products shows that laccase oxidizes the substrates to quinones or to polyaromatic oligomers. Slightly acidic conditions favor the formation of quinones as final transformation products. In contrast, at pH 5-6, the quinones further react with the remaining substrate in solution to give hetero-oligomers via carbon-carbon or carbon-oxygen bond formation. A reaction pathway is proposed for each of the identified products. These results demonstrate that fungal laccases could assist the transformation of hydroxyphenylureas.

Journal of Agricultural and Food Chemistry published new progress about C-C bond formation. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Safety of Methyl 4-chloro-2-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Deng, Xiangping; Liu, Renbo; Li, Junjian; Li, Zhongli; Liu, Juan; Xiong, Runde; Lei, Xiaoyong; Zheng, Xing; Xie, Zhizhong; Tang, Guotao published the artcile< Design, synthesis, and preliminary biological evaluation of 3',4',5'-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents>, Quality Control of 22717-55-1, the main research area is trimethoxy flavonoid salicylate derivative antitumor tubulin mol docking.

According to the pharmacophore combination principle, a set of new 3′,4′,5′-trimethoxy flavonoid salicylate derivatives were designed, synthesized, and evaluated for biol. activity. The cytotoxicity evaluation revealed that compound 10v exhibited higher potency than 5-Fu against HCT-116 cells. Preliminary biol. activity studies showed that compound 10v could inhibit the colony formation and migration of HCT-116 cells. Besides, the Hoechst 33258 staining assay and flow cytometry revealed that treatment with compound 10v induced the apoptosis of HCT-116 cells in a concentration-dependent manner, while it had no effect on their cell cycle. The WB anal. suggested that HIF-1α, tubulin, HK-2, and PFK might be the potential pharmacophore targets of compound 10v. Tubulin was a potential drug target for compound 10v, which was explained by analyzing the crystal structure of compound 10v complexed with tubulin. These results indicated that compound 10v might be a promising anti-tumor agent candidate, deserving further optimization and evaluation.

New Journal of Chemistry published new progress about Antitumor agents. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Quality Control of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shi, Xiu-dong; Ge, Bing-chen; Xu, Jiang-ping; Zhou, Zhong-zhen published the artcile< Synthesis, crystal structure and antitumor activity of 6-chloro-1-((6-chloropyridin-3-yl)methyl)-3-phenyl-1H-benzofuro[3,2-c]pyrazole>, Computed Properties of 22717-55-1, the main research area is benzofuropyrazole preparation crystal structure antitumor activity.

The title compound 6-chloro-1-((6-chloropyridin-3-yl)methyl)-3-phenyl-1H-benzofuro[3,2-c]pyrazole (I, C21H13Cl2N3O, Mr = 394.26) was synthesized and characterized by elemental anal., 1H NMR, 13C NMR and X-ray single-crystal diffraction. The structure reveals that the crystal belongs to the triclinic system, space group P1 with a = 7.8829(8), b = 10.3281(10), c = 11.7615(12)Å, α = 83.5552(2), β = 79.921(2), γ = 70.189(2) degree, V = 885.54(15)Å3, Z = 2, Dc = 1.479 g/cm3, μ = 0.383 mm-1, F(000) = 404, R = 0.0538 and wR = 0.1335 for 2453 observed reflections with I>2σ(I). The result revealed that the crystal structure of the title compound I was stabilized by three C-Cl···π interactions and π···πstacking interaction. In addition, the preliminary investigation showed that I exhibited remarkably good antitumor activity against the MCF-7 and A549 cell lines.

Chinese Journal of Structural Chemistry published new progress about Antitumor agents. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Computed Properties of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chang, Chia-Lin; Wu, Chin-Sheng; Wang, Sen-Wen; Wang, Jih-Pyang published the artcile< Synthesis and biological activity of 5-(2'-alkoxycarbonyl substituted phenoxy)furan-2-carboxylic acid derivatives>, SDS of cas: 22717-55-1, the main research area is alkoxycarbonylphenoxyfurancarboxylic acid derivative synthesis biol activity antiallergic antiinflammatory.

A series of 5-(2′-alkoxycarbonyl substituted phenoxy)furan-2-carboxylic acid derivatives were prepared by a facile synthetic route: reaction of Et 5-nitro-2-furoate with the corresponding salicylates. None of the compounds inhibited PMA-induced neutrophil superoxide formation. On the contrary, some carboxylates significantly inhibited fMLP-induced neutrophil degranulation with much greater activity than the pos. control, TFP. One compound also inhibited superoxide formation. Furthermore, another compound strongly inhibited β-glucuronidase and histamine release from mast cells. In particular, this compound was shown to be a novel lead compound with excellent anti-allergic and anti-inflammatory activities. The other compound was shown to be a novel lead compound with excellent anti-inflammatory activity.

Chinese Pharmaceutical Journal (Taipei, Taiwan) published new progress about Allergy. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, SDS of cas: 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zou, Xi; Sun, Guangwu; Huang, Hai; Wang, Jinping; Yang, Wen; Sun, Jianwei published the artcile< Catalytic Enantioselective Synthesis of 1,4-Benzodioxepines>, Safety of Methyl 4-chloro-2-hydroxybenzoate, the main research area is benzodioxepine enantioselective synthesis intramol desymmetrization oxetane benzylic alc.

An efficient organocatalytic enantioselective synthesis of chiral 1,4-benzodioxepines is described. By proper incorporation of an intramol. oxetane desymmetrization process, a range of benzylic alcs. bearing an internal oxetane reacted in the presence of a suitable chiral phosphoric acid catalyst to form chiral 1,4-benzodioxepines with high enantioselectivity. This process provides a new catalytic asym. example of direct synthesis of seven-membered heterocycles with good stereocontrol.

Organic Letters published new progress about Aralkyl alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (oxetane). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Safety of Methyl 4-chloro-2-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Boyd, Derek R.; Sharma, Narain D.; Harrison, John S.; Malone, John. F.; McRoberts, W. Colin; Hamilton, John T. G.; Harper, David B. published the artcile< Enzyme-catalyzed synthesis and reactions of benzene oxide/oxepine derivatives of methyl benzoates>, Related Products of 22717-55-1, the main research area is Phellinus enzyme benzoate ester metabolism.

A series of twelve benzoate esters was metabolized, by species of the Phellinus genus of wood-rotting fungi, to yield the corresponding benzyl alc. derivatives and eight salicylates. The isolation of a stable oxepine metabolite, from Me benzoate, allied to evidence of the migration and retention of a carbomethoxy group (the NIH Shift), during enzyme-catalyzed ortho-hydroxylation of alkyl benzoates to form salicylates, is consistent with a mechanism involving an initial arene epoxidation step. This mechanism was confirmed by the isolation of a remarkably stable, optically active, substituted benzene oxide metabolite of Me 2-(trifluoromethyl)benzoate, which slowly converted into the racemic form. The arene oxide was found to undergo a cycloaddition reaction with 4-phenyl-1,2,4-triazoline-3,5-dione to yield a crystalline cycloadduct whose structure and racemic nature was established by X-ray crystallog. The metabolite was also found to undergo some novel benzene oxide reactions, including epoxidation to give an anti-diepoxide, base-catalyzed hydrolysis to form a trans-dihydrodiol and acid-catalyzed aromatization to yield a salicylate derivative via the NIH Shift of a carbomethoxy group.

Organic & Biomolecular Chemistry published new progress about Enzymes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Related Products of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bhuyan, Samuzal; Gogoi, Abhijit; Basumatary, Joneswar; Gopal Roy, Biswajit published the artcile< Visible-Light-Promoted Metal-Free Photocatalytic Direct Aromatic C-H Oxygenation>, SDS of cas: 22717-55-1, the main research area is benzene alc photochem oxygenation; hydroxyalkyl benzene photochem oxygenation.

A mild atom-economic visible-light photocatalytic approach was developed for single-step synthesis of diverse aryl alcs., ethers and esters through direct C-H functionalization of aromatic ring at ambient condition. This approach used DDQ as photocatalyst and TBN as co-catalyst to facilitate the substitution of aromatic C-H by neutral nucleophile oxygen of water, alcs. and carboxylic acids and it used aerobic oxygen as the terminal oxidant to produce water as the only byproduct.

European Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, SDS of cas: 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics