Category: 22717-55-1

Venkatesan, Aranapakam M.; Dos Santos, O.; Ellingboe, John; Evrard, Deborah A.; Harrison, Boyd L.; Smith, Deborah L.; Scerni, Rosemary; Hornby, Geoffrey A.; Schechter, Lee E.; Andree, Terrence H. published the artcile< Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity>, HPLC of Formula: 22717-55-1, the main research area is serotonin antagonist SERT reuptake inhibitor depression antidepressant; indole benzofuran derivative SAR preparation.

Several benzofuran derivatives linked to a 3-indoletetrahydropyridine through an alkyl chain were prepared and evaluated for serotonin transporter and 5-HT1A receptor affinities. Their design, synthesis and structure-activity relationships are described.

Bioorganic & Medicinal Chemistry Letters published new progress about 5-HT receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, HPLC of Formula: 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Carrillo-Arcos, Ulises A.; Rojas-Ocampo, Jonathan; Porcel, Susana published the artcile< Oxidative cyclization of alkenoic acids promoted by AgOAc>, Computed Properties of 22717-55-1, the main research area is benzodioxinone preparation; oxidative cyclization alkenoic acid silver acetate.

Alkenoic acids derived from salicylic acid and analogs undergo an unexpected oxidative cyclization process triggered by AgOAc leading to 4H-benzo[d][1,3]dioxin-4-ones. The process is affected by the substitution on the aryl and the allyl units.

Dalton Transactions published new progress about Carboxylic acids, unsaturated Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Computed Properties of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fritzson, Ingela; Bedingfield, Paul T. P.; Sundin, Anders P.; McConkey, Glenn; Nilsson, Ulf J. published the artcile< N-Substituted salicylamides as selective malaria parasite dihydroorotate dehydrogenase inhibitors>, Name: Methyl 4-chloro-2-hydroxybenzoate, the main research area is substituted salicylamide recombinant human Plasmodium dihydroorotate dehydrogenase inhibitor.

In our continuing program to develop Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors, a series of N-substituted salicylamides were synthesized and their ability to selectively inhibit PfDHODH was examined The synthetic program was based on 2-hydroxy-N-(2-phenylethyl)benzamide (1) that weakly inhibits both PfDHODH and human DHODH (hDHODH). Structure activity relationships were examined for developing derivatives Selective PfDHODH inhibitors with improved potency were obtained by introducing a 2,2-diphenylethyl substitution on the salicylamidic nitrogen. Biol. activity of the most potent compounds was confirmed on parasite infected cells in vitro.

MedChemComm published new progress about Erythrocyte. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Name: Methyl 4-chloro-2-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics