Category: 22952-32-5

Bellotti, Peter; Koy, Maximilian; Gutheil, Christian; Heuvel, Steffen; Glorius, Frank published the artcile< Three-component three-bond forming cascade via palladium photoredox catalysis>, Quality Control of 22952-32-5, the main research area is carbocycle heterocycle preparation; bromide diene nucleophile bond forming cascade palladium photoredox catalysis.

A highly modular radical cascade strategy based upon radical cyclization/allylic substitution sequence between alkyl/aryl bromides, 1,3-dienes and nucleophiles ranging from sulfinates to amines, phenols and 1,3-dicarbonyls was described. Palladium phosphine complexes – which merge properties of photo- and cross coupling-catalysts – allowed to forge three bonds with complete 1,4-selectivity and stereocontrol, delivering highly value added carbocyclic and heterocyclic motifs that could feature – inter alia – vicinal quaternary centers, free protic groups, gem-difluoro motifs and strained rings. Furthermore, a flow chem. approach was for the first time applied in palladium-photocatalyzed endeavors involving radicals.

Chemical Science published new progress about 1,3-Alkadienes Role: RCT (Reactant), RACT (Reactant or Reagent). 22952-32-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O3S, Quality Control of 22952-32-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Macdonald, Jonathan D.; Chacon Simon, Selena; Han, Changho; Wang, Feng; Shaw, J. Grace; Howes, Jennifer E.; Sai, Jiqing; Yuh, Joannes P.; Camper, Demarco; Alicie, Bethany M.; Alvarado, Joseph; Nikhar, Sameer; Payne, William; Aho, Erin R.; Bauer, Joshua A.; Zhao, Bin; Phan, Jason; Thomas, Lance R.; Rossanese, Olivia W.; Tansey, William P.; Waterson, Alex G.; Stauffer, Shaun R.; Fesik, Stephen W. published the artcile< Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction>, Recommanded Product: 5-Chloro-2-methoxybenzenesulfonyl chloride, the main research area is neoplasm WDR5 MYC protein interaction crystal structure.

The treatment of tumors driven by overexpression or amplification of MYC oncogenes remains a significant challenge in drug discovery. Here, we present a new strategy toward the inhibition of MYC via the disruption of the protein-protein interaction between MYC and its chromatin cofactor WD Repeat-Containing Protein 5. Blocking the association of these proteins is hypothesized to disrupt the localization of MYC to chromatin, thus disrupting the ability of MYC to sustain tumorigenesis. Utilizing a high-throughput screening campaign and subsequent structure-guided design, we identify small-mol. inhibitors of this interaction with potent in vitro binding affinity and report structurally related neg. controls that can be used to study the effect of this disruption. Our work suggests that disruption of this protein-protein interaction may provide a path toward an effective approach for the treatment of multiple tumors and anticipate that the mols. disclosed can be used as starting points for future efforts toward compounds with improved drug-like properties.

Journal of Medicinal Chemistry published new progress about Crystal structure. 22952-32-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O3S, Recommanded Product: 5-Chloro-2-methoxybenzenesulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Tian-bang; Xiang, Qiu-ping; Wang, Chao; Wu, Chun; Zhang, Cheng; Zhang, Mao-feng; Liu, Zhao-xuan; Zhang, Yan; Xiao, Lin-jiu; Xu, Yong published the artcile< Y06014 is a selective BET inhibitor for the treatment of prostate cancer>, Formula: C7H6Cl2O3S, the main research area is dimethylisoxazolyl benzoindolone preparation BET inhibitor SAR antitumor human docking; BRD4; Y06014; androgen receptor; bromodomain inhibitor; prostate cancer.

The design, synthesis and a structure-activity relationship study of 6-(3,5-dimethylisoxazol-4-yl)benzo[cd]indol-2(1H)-one derivative I [R = Et, PhSO2, PhCH2CH2CH2, etc.] as novel selective BET inhibitors was reported. One representative compound, compound I [R = Et], bound to BRD4(1) in the low micromolar range and demonstrated high selectivity for BRD4(1) over other non-BET bromodomain-containing proteins. This mol. also potently inhibited cell growth, colony formation and mRNA expression of AR-regulated genes in PC cell lines. The compound I [R = Et] also showed stronger activity than the second-generation antiandrogen enzalutamide. The compound I [R = Et] might serve as a new small mol. probe for further validation of BET as a mol. target for PC drug development.

Acta Pharmacologica Sinica published new progress about Antitumor agents. 22952-32-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O3S, Formula: C7H6Cl2O3S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Roberts, Dean D.; McLaughlin, Mark G. published the artcile< Regioselective Synthesis of Multifunctional Allylic Amines; Access to Ambiphilic Aziridine Scaffolds>, Synthetic Route of 22952-32-5, the main research area is allylic amine ambiphilic aziridine preparation regioselective; propargylic amine dimethylphenylsilane hydrosilylation platinum chloride XantPhos catalyst.

A highly regioselective hydrosilylation of propargylic amines has been described here for the first time. The reaction utilizes a PtCl2/XantPhos catalyst system to deliver hydrosilanes across the alkyne to afford multifunctional allylic amines in high yields. The reaction is tolerant to a wide variety of functional groups and provides high value intermediates with two distinct functional handles. The synthetic applicability of the reaction has been shown through the synthesis of diverse ambiphilic aziridines.

Organic Letters published new progress about Allyl amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22952-32-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O3S, Synthetic Route of 22952-32-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Washburn, Alex; Abdeen, Sanofar; Ovechkina, Yulia; Ray, Anne-Marie; Stevens, Mckayla; Chitre, Siddhi; Sivinski, Jared; Park, Yangshin; Johnson, James; Hoang, Quyen Q.; Chapman, Eli; Parish, Tanya; Johnson, Steven M. published the artcile< Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections>, Reference of 22952-32-5, the main research area is benzoxazolylphenyl phenylbenzoxazolyl sulfonamide preparation; inhibition GroEL ES chaperonin PtpB benzoxazolylphenyl phenylbenzoxazolyl sulfonamide; antimycobacterial activity toxicity benzoxazolylphenyl phenylbenzoxazolyl sulfonamide; Antibiotics; Chaperonin; GroEL; GroES; HSP10; HSP60; Molecular chaperone; Mycobacterium tuberculosis; Phosphatases; Polypharmacology; Proteostasis; Small molecule inhibitors.

Benzoxazolylphenyl sulfonamides I (R = Me, Ph, 2-thienyl, 2-FC6H4, 3-FC6H4, 4-FC6H4, 2-ClC6H4, 3-ClC6H4, 4-ClC6H4, 5-chloro-2-thienyl, 2-F3CC6H4, 3-F3CC6H4, 4-F3CC6H4, 3,4-Cl2C6H3, 4-F-3-F3CC6H3, 4-Cl-3-F3CC6H3, 4-Cl-3-O2NC6H3, 5-Cl-2-MeOC6H3, 2-MeC6H4, 3-MeC6H4, 4-MeC6H4, 4-EtC6H4, 4-H2C:CHC6H4, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 2-HOC6H4, 3-HOC6H4, 4-HOC6H4) and phenylbenzoxazolyl sulfonamides II (R = Me, Ph, 2-thienyl, 2-FC6H4, 3-FC6H4, 4-FC6H4, 2-ClC6H4, 3-ClC6H4, 4-ClC6H4, 5-chloro-2-thienyl, 2-F3CC6H4, 3-F3CC6H4, 4-F3CC6H4, 3,4-Cl2C6H3, 4-F-3-F3CC6H3, 4-Cl-3-F3CC6H3, 4-Cl-3-O2NC6H3, 5-Cl-2-MeOC6H3, 2-MeC6H4, 3-MeC6H4, 4-MeC6H4, 4-EtC6H4, 4-H2C:CHC6H4, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 2-HOC6H4, 3-HOC6H4, 4-HOC6H4) were prepared as dual inhibitors of GroEL/ES and the virulence factor protein tyrosine phosphatase B (PtpB) for the treatment of Mycobacterium tuberculosis infection at all stages of bacterial infection.

Bioorganic & Medicinal Chemistry Letters published new progress about Benzoxazoles Role: ADV (Adverse Effect, Including Toxicity), PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 22952-32-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O3S, Reference of 22952-32-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics