Category: 23082-45-3

Umio, Suminori published the artcileTotal synthesis of pyrrolnitrin. VI. Synthesis of nitrochloro-2-aminoacetophenones and 1-aryl-1,3-butanediones, Quality Control of 23082-45-3, the main research area is pyrrolnitrin synthesis; acetophenones nitro chloro amino; butanediones aryl.

Synthetic methods nitro-chloro-2-aminoacetophenones XYC6H3COCH(NH2)R (I) (X = 2-NO2, 3-NO2, 4-NO2; Y = 3-Cl, H, 4-Cl; and R = H, Me), and 1-(nitrochlorophenyl)-1,3-butanediones XYC6H3COCH2COCH2R (II) (X = 2-NO2, 4-NO2; Y = 3-Cl, H, 4-Cl, 5-Cl), starting materials for the synthesis of pyrrolnitrin (III) and related compounds, were investigated. Never rearrangement was suitable for the preparation of I. Cleavage of Et 2-(nitro-chlorobenzoyl) acetoacetate and a 2,4-pentanedione derivative led to II.

Chemical & Pharmaceutical Bulletin published new progress about pyrrolnitrin synthesis; acetophenones nitro chloro amino; butanediones aryl. 23082-45-3 belongs to class chlorides-buliding-blocks, name is 3,5-Dichloro-2-nitrobenzoic acid, and the molecular formula is C7H3Cl2NO4, Quality Control of 23082-45-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Penglie published the artcileDiscovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor, SDS of cas: 23082-45-3, the main research area is betrixaban factor Xa inhibitor.

Systematic SAR studies of in vitro factor Xa inhibitory activity around N-[(5-chloropyridin-2-yl)-2-(4-N,N-dimethylcarbamimidoyl)benzamido]benzamide were performed by modifying each of the three Ph rings. A class of highly potent, selective, efficacious and orally bioavailable direct factor Xa inhibitors was discovered. These compounds were screened in hERG binding assays to examine the effects of substitution groups on the hERG channel affinity. From the leading compounds, betrixaban (PRT054021) has been selected as the clin. candidate for development.

Bioorganic & Medicinal Chemistry Letters published new progress about Anticoagulants. 23082-45-3 belongs to class chlorides-buliding-blocks, name is 3,5-Dichloro-2-nitrobenzoic acid, and the molecular formula is C7H3Cl2NO4, SDS of cas: 23082-45-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics