Rivkin, Alexey; Ahearn, Sean P.; Chichetti, Stephanie M.; Hamblett, Christopher L.; Garcia, Yudith; Martinez, Michelle; Hubbs, Jed L.; Reutershan, Michael H.; Daniels, Matthew H.; Siliphaivanh, Phieng; Otte, Karin M.; Li, Chaomin; Rosenau, Andrew; Surdi, Laura M.; Jung, Joon; Hughes, Bethany L.; Crispino, Jamie L.; Nikov, George N.; Middleton, Richard E.; Moxham, Christopher M.; Szewczak, Alexander A.; Shah, Sanjiv; Moy, Lily Y.; Kenific, Candia M.; Tanga, Flobert; Cruz, Jonathan C.; Andrade, Paula; Angagaw, Minilik H.; Shomer, Nirah H.; Miller, Thomas; Munoz, Benito; Shearman, Mark S. published the artcile< Purine derivatives as potent γ-secretase modulators>, COA of Formula: C6H4Cl2N4, the main research area is purine derivative preparation gamma secretase Alzheimer’s amyloid structure.
The development of a novel series of purines as γ-secretase modulators for potential use in the treatment of Alzheimer’s disease is disclosed herein. Optimization of a previously disclosed pyrimidine series afforded a series of potent purine-based γ-secretase modulators with 300- to 2000-fold in vitro selectivity over inhibition of Notch cleavage and that selectively reduces Αβ42 in an APP-YAC transgenic mouse model.
Bioorganic & Medicinal Chemistry Letters published new progress about Alzheimer disease. 2382-10-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H4Cl2N4, COA of Formula: C6H4Cl2N4.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics