Research on new synthetic routes about 2415-80-7

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (2,2-Dichlorocyclopropyl)benzene, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 2415-80-7, name is (2,2-Dichlorocyclopropyl)benzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2415-80-7, Formula: C9H8Cl2

General procedure: a. To a vigorously stirred solution of 0.01 mol of gem-dichloro(bromo)cyclopropane 1a-1h in 30 mL of absolute THF dropwise at -78C under argon 5.5 mL of a 2 M solution of n-butyllithium in cyclohexane (0.011 mol) was added. The resulting mixture was stirred at -78 for 15 min, purged for 2 h at the same temperature with CO2 dried with H2SO4, and then heated to 0C and diluted with 30 mL of water. The aqueous solution was washed with 20 mL of diethyl ether, brought to pH 3 with HCl, and extracted with methylene chloride (3¡Á30 mL). The extract was dried over Na2SO4, and the solvent was removed by distillation to leave alpha-halocyclopropanecarboxylic acids 4a-4h. The spectral characteristics of the products are consistent with those reported in [1, 9]. The mass spectra of the cis and trans isomers of compound 4b-4d are identical to each other. b. The synthesis of 2-substituted alpha-halocyclopropanecarboxylic acids in the presence of LiCl was performed by the same procedure. Lithium chloride, 0.01 mol (0.424 g), was added to the solution of 0.01 mol of gem-dichloro(bromo)cyclopropane 1 before the addition of butyllithium. c. To a vigorously stirred solution of 0.01 mol (0.785 g) of propyl chloride in 30 mL of absolute THF dropwise at -15C under argon 5.5 mL (0.011 mol) of a 2 solution of n-butyllithium in cyclohexane was added. The reaction mixture was heated to 25 and stirred for an additional 60 min. gem-Dihalocyclopropane 1a-1h, 0.01 mol, was then added, and mixture was stirred for 15 min at -78C, after which 5.5 mL of a 2 solution of n-butyllithium in cyclohexane was added. Further workup was performed as described above.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (2,2-Dichlorocyclopropyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zagidullin; Zorin; Zorin; Russian Journal of General Chemistry; vol. 86; 10; (2016); p. 2307 – 2311; Zh. Obshch. Khim.; vol. 86; 10; (2016); p. 1659 – 1663;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics