Category: 24279-39-8

These common heterocyclic compound, 24279-39-8, name is 2,6-Dichloro-4-(trifluoromethyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: chlorides-buliding-blocks

EXAMPLE 5 A solution of sodium nitrite (3.2 g) in concentrated sulphuric acid (22 ml) was added dropwise with cooling to a solution of 2,6-dichloro-4-trifluoromethylaniline (9.3 g) in glacial acetic acid (48 ml). The mixture was stirred at room temperature for half an hour and then cooled to 0-5. A solution of sodium azide (2.6 g) in the and the mixture stirred at 0-5 for 1 hour and then at room temperature overnight. The mixture was poured into ice/water, extracted with dichloromethane and the extract worked up in conventional manner to give 1-azido-2,6-dichloro-4-trifluoromethylbenzene, as a red oil.

The synthetic route of 2,6-Dichloro-4-(trifluoromethyl)aniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Schering Agrochemicals Limited; US5109012; (1992); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 24279-39-8, These common heterocyclic compound, 24279-39-8, name is 2,6-Dichloro-4-(trifluoromethyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation 17; 2, 6-DICHLORO-4- (TRIFLUOROMETHYL) PHENYLDIAZONIUM TETRAFLUOROBORATE To a stired solution of 2,6-dichloro-4-(trifluoromethyl)aniline (11. 74 g, 0. 05 mol) in ethanol (12 ml) at -5C was added tetrafluoroboric acid (48% in water, 14 ml. 0.11 mol). A white precipitate formed accompanied by an increase in temperature to 5C. The reaction mixture WAS RECOOLED TO-5C. ISOAMYL nitrite (6.58 g, 56.1 mmol) was added dropwise over 5 min, the temperature rose to 3C. The reaction mixture was cooled TO-5C-AND stirred for 5 min before allowing to warm to ambient temperature for 30 min. The reaction mixture was filtered and the precipitate washed with absolute ethanol (11 ml) and diethyl ether (10 ML) to give Preparation 17 (14.91 g, 89%) as a crystalline solid. NMR (D20, selected data): 8. 3 (s, 2H).

The synthetic route of 24279-39-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/23773; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 24279-39-8, name is 2,6-Dichloro-4-(trifluoromethyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2,6-Dichloro-4-(trifluoromethyl)aniline

EXAMPLE 5 A solution of sodium nitrite (3.2 g) in concentrated sulphuric acid (22 ml) was added dropwise with cooling to a solution of 2,6-dichloro-4-trifluoromethylaniline (9.3 g) in glacial acetic acid (48 ml). The mixture was stirred at room temperature for half an hour and then cooled to 0-5. A solution of sodium azide (2.6 g) in the and the mixture stirred at 0-5 for 1 hour and then at room temperature overnight. The mixture was poured into ice/water, extracted with dichloromethane and the extract worked up in conventional manner to give 1-azido-2,6-dichloro-4-trifluoromethylbenzene, as a red oil.

The synthetic route of 2,6-Dichloro-4-(trifluoromethyl)aniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Schering Agrochemicals Limited; US5109012; (1992); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 24279-39-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24279-39-8, name is 2,6-Dichloro-4-(trifluoromethyl)aniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 6; Ethyl 2- {5-amino-3-cyano-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazol-4- YL} CYCLOPROPANECARBOXYLATE; To a stirred solution OF 2, 6-DICHLORO-4- (TRIFLUOROMETHYL) PHENYLAMINE (3.0 g, 13 mmol) in ethanol (3 MT) at–5C was added TETRAFLUOROBORIC acid (48% in water, 27.3 MINOT). To the mixture was added isoamyl nitrite (1.8 ml, 13. 6 MMOL), dropwise over 10 min, and the reaction mixture was stirred for 30 min at room temperature. The solid was filtered and WASHED-WITB ETHANOL, followed by diethyl ether,. to give. the diazonium salt (3.2g, 9. 73 NIMOL, 75%) as a white solid. To a solution of Preparation 6 (50 mg, 0.20 mmol) in acetonitrile (2 ml) at 0C was added diazonium-salt (65 mg, 0.20 mmol). The reaction mixture was then allowed to warm to room temperature with stirring. The solution was concentrated under a stream of nitrogen and to the residue was added dichloromethane (2. 5 ml), ammonia (0.880, 2.5 ml) and water (2.5 ml), with vigorous stirring. The. mixture was partitioned between water (20 ml) and dichloromethane- (20 ml) and the two layers were separated. The aqueous layer was extracted with dichloromethane (2 X 10 ml) and the combined organic layers were dried (NA2SO4) and concentrated in vacuo. The residue was loaded on to an ABSOLUTE column (silica, 2 g) in a mixture of cyclohexane and dichloromethane mixture (4 :-1) and eluted with cyclohexane : ethyl acetate [1 : 0 to 3 : 7]. The appropriate fractions were combined and concentrated to give the product (15 mg, 0, 03 mmol, 17 %) as an orange oil. MS (ES) M/Z [MH+]. = 433. 42,. C17H13C12F3N402 +H REQUIRES 433. 04459. NMR (CDC13, selected data): 1.35 (t, 3H), 1.6-1. 7 (m, 2H), 1. 9- 2.0 (m, 1H), 2.0-2. 1 (m, 1H), 3.65 (S, 2H), 4. 2 (q, 2H), 8.8 (M, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dichloro-4-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/23773; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 24279-39-8, These common heterocyclic compound, 24279-39-8, name is 2,6-Dichloro-4-(trifluoromethyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

CuBr2 (4.02 g, 18.0 mmol) and tert-butyl nitrite (3.12 g, 30.3 mmol)were added together with MeCN (60 mL) to a three-necked flask underargon. In a separate flask, 2,6-dichloro-4-trifluoromethylaniline(3.5 g, 15.2 mmol) was dissolved in MeCN (20 mL) under argon. Theaniline solution was then added dropwise to the three-necked flaskcontaining the nitrite mixture. The reaction mixture was then heatedto 65 C and stirred overnight. The mixture was cooled to r.t. andpoured into a separatory funnel with H2O (50 mL) and Et2O (110 mL).The organic layer was separated and washed with aq 3 M HCl (2 ¡Á 30mL). The organic layer was dried (Na2SO4), concentrated by rotaryevaporation and high vacuum to completely remove the volatiles;yield: 3.79 g (85%); colorless oil.1H NMR (300 MHz, CDCl3): delta = 7.63 (s, 2 H).13C NMR (100 MHz, CDCl3): delta = 137.4, 131.1 (q, J = 34 Hz), 127.9, 125.2(q, J = 3.1 Hz), 122.4 (q, J = 271 Hz).

Statistics shows that 2,6-Dichloro-4-(trifluoromethyl)aniline is playing an increasingly important role. we look forward to future research findings about 24279-39-8.

Reference:
Article; Miller, Daniel K.; Bailey, Christopher A.; Sammelson, Robert E.; Synthesis; vol. 47; 18; (2015); p. 2791 – 2798;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

24279-39-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24279-39-8 as follows.

ASE 215 To a refluxing solution of 9.20 g (40.0 mmoles) of 2,6-dichloro-4-trifluoromethylaniline and 0.76 g (4.0 mmoles) of p-toluenesulfonic acid monohydrate in 25 mL of benzene was added dropwise over an 8 hour period with a syringe pump 9.40 mL (9.14 g, 80.1 mmoles) of acetonylacetone. Throughout the addition, water was removed via a Dean-Stark trap. The reaction mixture was then cooled and partitioned with a saturated aqueous solution of NaHCO3 which was back-extracted with ether. The combined organic layers were dried over anhydrous Na2 SO4 concentrated. The residual brown oil was chromatographed on silica gel with a 95:5 v/v hexane-EtOAc eluent to afford 10.0 g (81%) of 1-(2,6-dichloro-4-trifluoromethylphenyl)-2,5-dimethylpyrrole as a light brown solid of melting point 63 C.

According to the analysis of related databases, 2,6-Dichloro-4-(trifluoromethyl)aniline, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Rhone-Poulenc AG Company; US5187185; (1993); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 24279-39-8, name is 2,6-Dichloro-4-(trifluoromethyl)aniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24279-39-8, 24279-39-8

REFERENCE EXAMPLE 3 Nitrosyl sulphuric acid, prepared from sodium nitrite (69 g, 1 mol) and concentrated sulphuric acid (600 ml) was added dropwise with stirring to a cooled solution of 2,6-dichloro-4-trifluoromethylaniline (230 g, 1 mol) in glacial acetic acid (1250 ml) at 15-20 C. The mixture was stirred for 1 hour at ambient temperature. The diazonium mixture was run slowly into a solution prepared from cuprous bromide (143.4 g, 1 mol), hydrobromic acid (48%, 1 l) and ice (approx. 1000 g) at a rate so as not to exceed a temperature of 35 C. After 1 hour the mixture was steam distilled to give 1 l of distillate which was diluted with water (3 l) and extracted with diethyl ether (2*500 ml). The organic fractions were combined and washed with aqueous sodium hydroxide solution (2M, 2*250 ml) and water (250 ml), dried over anhydrous sodium sulphate and evaporated to dryness. The oily residue was distilled to give 1-bromo-2,6-dichloro-4-trifluoromethylbenzene (256.8 g) as a colourless liquid, b.p. 74-78 C. at 6 mmHg.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dichloro-4-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; May & Baker Limited; US5206257; (1993); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24279-39-8 as follows. 24279-39-8

Reference Production Example 10 First, 31.4 g (120 mmol) of triphenylphosphine and 4.9 g (48 mmol) of triethylamine were added to 20 ml of carbon tetrachloride, to which 3.8 g (40 mmol) of difluoroacetic acid was added dropwise under ice cooling. After completion of the dropwise addition, the mixture was stirred under ice cooling for 10 minutes. Then, a solution of 9.2 g (40 mmol) of 2,6-dichloro-4-trifluoromethylaniline in 20 ml of carbon tetrachloride was added dropwise to the reaction mixture, which was heated at 80 C. for 6 hours. The reaction mixture was concentrated under reduced pressure, followed by addition of hexane, and undissolved matter was removed by filtration. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 6.0 g of N-(2,6-dichloro-4-trifluoromethylphenyl)-2,2-difluoroacetimidoyl chloride. 1H-NMR (300 MHz, CDCl3/TMS): delta (ppm)=7.65 (s,21), 6.38 (t, J=54.1 Hz, 1H)

According to the analysis of related databases, 24279-39-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Matsumoto, Osamu; Uekawa, Toru; US2001/41740; (2001); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics