Category: 243139-71-1

He, Renbao published the artcileSynthesis of 2,4,5-trifluorobenacetic acid, Quality Control of 243139-71-1, the publication is Huagong Shengchan Yu Jishu (2011), 18(3), 4-6, database is CAplus.

The compound 2,4,5-trifluorobenzeneacetic acid was synthesized from 1,2,4-trifluorobenzene via chloromethylation, carbonylation and hydrolyzation. Results showed that the optimization synthesis condition of 2,4,5-trifluorobenzyl chloride were as follows: m (C₆H₃F₃):m (paraformaldehyde)=1.0:0.875-0.865, reaction time 10 h. And the optimization synthesis condition of 2,4,5-trifluorobenzeneacetic acid was m (C₇H₄F₃Cl): m (cat)=1:0.275-0.25 and the reaction temperature was 40°C, under this condition, the total yield was above 60%, the purity was above 99%. The proportion of reactants and dosage of catalyst were discussed.

Huagong Shengchan Yu Jishu published new progress about 243139-71-1. 243139-71-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 2,4,5-Trifluorobenzyl chloride, and the molecular formula is C7H4ClF3, Quality Control of 243139-71-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mohammadhosseini, Negar published the artcileSynthesis and biological evaluation of novel benzyl piperazine derivatives of 5-(5-nitroaryl)-1,3,4-thiadiazoles as anti-Helicobacter pylori agents, Name: 2,4,5-Trifluorobenzyl chloride, the publication is Daru, Journal of Pharmaceutical Sciences (2013), 66/1-66/8, 8 pp., database is CAplus and MEDLINE.

A series of 1-(substituted benzyl)-4-(5-(5-nitroheteroaryl-2-yl)-1,3,4-thiadiazol-2-yl) piperazine derivatives I [X = O, S; R= 3-MeO, 2-O₂N, 2,5-(Cl)₂, 2,4,5-(F)₃, etc.] were synthesized. The synthesized compounds I were evaluated against three metronidazole-resistant isolates of Helicobacter pylori using disk diffusion bioassay test. The results of SAR study indicated that the potency and anti-H. pylori activity profile of synthesized derivatives was mainly attributed to the substituted nitroaryl moiety at the C-5 position of 1,3,4-thiadiazole ring. Compound I [X = O; R = 3-MeO] was found to be the most potent.

Daru, Journal of Pharmaceutical Sciences published new progress about 243139-71-1. 243139-71-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 2,4,5-Trifluorobenzyl chloride, and the molecular formula is C7H4ClF3, Name: 2,4,5-Trifluorobenzyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Modak, Atanu published the artcilePalladium-Catalyzed Remote meta-Selective C-H Bond Silylation and Germanylation, Synthetic Route of 243139-71-1, the publication is Organometallics (2017), 36(13), 2418-2423, database is CAplus.

Selective meta-C-H activation of arenes until date has met with a limited number of functionalizations. Expanding the horizon of meta-C-H functionalization, herein the authors disclose an unprecedented meta-silylation and germanylation protocol by employing a simple nitrile based directing template. Longer linker between the target site and the directing template were successfully explored for meta-silylation (sp²ε and sp²ζ). Addnl., synthetic utility was demonstrated with several postsynthetic elaborations and with a formal synthesis of TAC101, a promising drug for the treatment of lung cancer.

Organometallics published new progress about 243139-71-1. 243139-71-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 2,4,5-Trifluorobenzyl chloride, and the molecular formula is C7H4ClF3, Synthetic Route of 243139-71-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gou, Fei-Hu published the artcileNickel-catalyzed cross-coupling of amino-acid-derived alkylzinc reagents with alkyl bromides/chlorides: Access to diverse unnatural amino acids, Product Details of C7H4ClF3, the publication is Organic Letters (2022), 24(1), 240-244, database is CAplus and MEDLINE.

Unnatural α-amino acids are important synthetic targets in the field of peptide science. Herein we report an efficient, versatile, and straightforward strategy for the synthesis of homophenylalanine derivatives via the nickel-catalyzed Csp³-Csp³ cross-coupling of (fluoro)benzyl bromides/chlorides with natural α-amino-acid-derived alkylzinc reagents. The current protocol features the advantages of a low-cost nickel catalyst system, synthetic convenience, and the tolerance of rich functionality and stereochem.

Organic Letters published new progress about 243139-71-1. 243139-71-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 2,4,5-Trifluorobenzyl chloride, and the molecular formula is C7H4ClF3, Product Details of C7H4ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics