Category: 2533-69-9

2533-69-9, Adding some certain compound to certain chemical reactions, such as: 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2533-69-9.

General procedure: Preparation of 2-methyl-6-nitro-2H-indazole (5d). To a stirred mixture of 6-nitro-1H-indazole (1.0 g, 0.0061 mmol) in dichloromethane (25.0 mL) was added trifluoromethanesulfonic acid (0.54 mL, 0.0061 mmol), stirred for 5-10 min at 25-35 C. To this mixture was added methyl 2,2,2,-trichlroacetimidate (2.69 g, 0.015 mmol) at room temperature. The reaction mixture was stirred at room temperature for 16-18 h under N2. After reaction completion, chilled saturated NaHCO3 solution was added. The aqueous and organic phases were separated. Aqueous phase was extracted with dichloromethane 10 mL. Combined organic layers were washed with DM water (2 ¡Á 10 mL). Organic layer was dried over anhydrous Na2SO4, filtered, and evaporated completely under vacuum to obtain 2-methyl-6-nitro-2H-indazole (1.03 g, 95.0%) as a yellow solid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2533-69-9.

Reference:
Article; Baddam, Sudhakar Reddy; Uday Kumar; Panasa Reddy; Bandichhor, Rakeshwar; Tetrahedron Letters; vol. 54; 13; (2013); p. 1661 – 1663;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2533-69-9, Adding a certain compound to certain chemical reactions, such as: 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2533-69-9.

To a suspension, cooled to 0 C., of 1.50 g (8.97 mmol) of N1-methyl-4-nitrobenzene-1,2-diamine in 40.0 ml of glacial acetic acid were added dropwise 1.22 ml (9.87 mmol) of methyl 2,2,2-trichloroacetimidate and the mixture was stirred at RT for 3 h. For workup, the mixture was added to water, and the solid was filtered off and washed with water. The solid was dried at 50 C. under high vacuum. This gave 2.50 g (93% of theory) of the title compound. LC-MS (Method 1): Rt=1.06 min; MS (ESIpos): m/z=296 (M+H)+. 1H NMR (400 MHz, DMSO-d6): delta [ppm]=4.20 (s, 3H), 8.00 (d, 1H), 8.35 (dd, 1H), 8.75 (d, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,2,2-trichloroacetimidate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; Fuerstner, Chantal; Ackerstaff, Jens; Straub, Alexander; Meier, Heinrich; Tinel, Hanna; Zimmermann, Katja; Tersteegen, Adrian; Zubov, Dmitry; Kast, Raimund; Schamberger, Jens; Schaefer, Martina; Boerngen, Kirsten; US2015/148340; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2533-69-9, These common heterocyclic compound, 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Methyl 2,2,2-trichloroacetimidate (408 ml, 3.30 mmol), diisopropylethylamine (473 ml, 2.72 mmol) and ammonium chloride (73 mg, 1.36 mmol) were added to a solution of compound 96 (943 mg, 3.00 mmol) in acetic acid (6.0 ml) under ice-cooling, and the mixture was stirred for 45 minutes at room temperature. After water (15 ml) was added to the reaction mixture, precipitated crystals were collected and dissolved in THF (27 ml). 5 N sodium hydroxide solution (3 ml) was added to the solution and the mixture was stirred for 1 .5 hours at room temperature. The reaction mixture was concentrated and acidified to pH 3 – 4 with 2 N hydrochloric acid. Precipitated crystals were collected and washed with water to give compound 99 (770 mg, 70 %) as reddish-brown crystals. NMR (CDCl3) ?: 4.28 (3H, s), 4.45 (2H; s), 7.06 (2H, m), 7:33-(1H; d; J=8.5Hz), 7.39 (2H, m), 7.80 (1H, d, J = 8.6 Hz).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2533-69-9.

Reference:
Patent; SHIONOGI & CO., LTD.; EP1375486; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2533-69-9, Adding a certain compound to certain chemical reactions, such as: 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2533-69-9.

[00748] To a solution of 4-chloro-5-(4-chlorobenzyloxy)benzene-1,2-diamine (282 mg, 1 mmol) in DCM (4 mL) and ethyl ether (1.6 mL) at 0C was added methyl 2,2,2-trichloroacetimidate (260 mg, 1.5 mmol) and TFA (1.6 mL). The resulting reaction mixture was stirred at 15C for 20 h. The reaction was quenched by adding ice, and white solid was formed, and then filtered. The solid was washed with excess DCM. The filtrate was concentrated in vacuo at 20C to give the residue (200 mg) as a tan gum,. The residue was used directly in the next step. ESI-MS (EI+, m/z):

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,2,2-trichloroacetimidate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NAVITOR PHARMACEUTICALS, INC.; MAHONEY, Sarah; MOLZ, Lisa; NARAYAN, Sridhar; SAIAH, Eddine; (516 pag.)WO2018/191146; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2533-69-9, These common heterocyclic compound, 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To the solution containing 4,5-diaminobenzo-15-crown-5 prepared in the last step, methyl 2,2,2-trichloroacetimidate (90 L, 0.70 mmol) was added. The mixture was stirred at rt shielded from light. After 9h, K2CO3 (6.0 g) was added to the mixture. The mixture was stirred for 11 h. The solvent was evaporated to give brown solid. Deionized water (70 mL) was added to the solid, and the mixture was stirred at rt for 5 h. The precipitate was filtered on Celite 545 mu, and washed with deionized water. The precipitate was eluted with a mixture of CHCl3/MeOH (1/1). The solution was concentrated under reduced pressure to give light brown solid, which was passed through a short alumina column chromatography by using a mixture of CHCl3/MeOH (10/1) as an eluent. The fractions were concentrated, and the residue was recrystalized from acetic acid to give 1 (104 mg, 21%) as pale yellow crystal. HRMS (FAB) m/z ([M + Na]+) 637.2486, calcd for C30H38N4O10Na 637.2486. 1H NMR (600 MHz, CDCl3): 7.05 (s, 4H, Ar), 3.96 (br, 8H, crown), 3.86 (br, 8H, crown), 3.75 (br, 16H, crown); 13C NMR (150 MHz, CDCl3): 148.19 (C), 142.92 (C), 133.03 (C), 99.26 (CH), 70.81 (CH2), 70.15 (CH2), 69.22 (CH2), 69.07 (CH2).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2533-69-9.

Reference:
Article; Satake, Akiharu; Tanaka, Kazuo; Asakura, Hiroki; Okano, Masahiro; Hashimoto, Tsutsumu; Matsuura, You; Inaba, Yusuke; Oda, Tetsuhisa; Hirota, Shun; Koshino, Hiroyuki; Bulletin of the Chemical Society of Japan; vol. 87; 1; (2014); p. 88 – 97;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2533-69-9 as follows. 2533-69-9

24. 55 mmol of PHENYLENEDIAMINE 1a-k, 1M, In were dissolved in 50 ml of acetic acid, AND 27 MMOL of methy 2, 2, 2-TRICHFOROACETIMIDATE 2 WERE added at 0C over the course of 0.5 hour under an N2 atmosphere. When the addition was complete, the reaction mixture was slowly warmed to room temperature and stirred at this temperature for 2 hours. The reaction mixture was poured into ice-water, and the resulting precipitate was filtered off with suction, washed with a little water and dried at 40C under reduced pressure. 3a: R = 5-Cl ; brown solid, yield : 82%

According to the analysis of related databases, 2533-69-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK PATENT GmbH; WO2005/4863; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics