2589-11-9, name is 6-Chloro-1H-imidazo[4,5-c]pyridine, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 6-Chloro-1H-imidazo[4,5-c]pyridine
C2. Methyl 5-(6-chloro-1H-imidazo[4,5-c]pyridin-1-yl)-3-hydroxythiophene-2-carboxylate (Compound C2a) and Methyl 5-(6-chloro-3H-imidazo[4,5-c]pyridin-3-yl)-3-hydroxythiophene-2-carboxylate (compound C2b) To a mixture of 0.68 g of 6-chloro-1H-imidazo[4,5-c]pyridine and 0.65 g of 2,2,6,6-tetramethylpiperidine in 100 ml chloroform is slowly added a solution of 0.87 g of methyl 2-chloro-3-oxo-2,3-dihydrothiophene-2-carboxylate in 40 ml chloroform. The reaction mixture is stirred for 12 h at room temperature. After washing with water (3 x 50 ml) the organic layer is separated, dried with MgSO4 and concentrated to a volume of about 100 ml. The residue is treated with n-hexane until precipitation takes place. The solid is filtered and the procedure is repeated once again. The combined solids are dried under vacuum to yield the title compounds as an isomeric mixture, which is used for the next step (example B3) without further purification. LC-MS (MH+ found) = 310.0 (isomeric mixture)
The synthetic route of 2589-11-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; 4SC AG; EP2017277; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics