2613-34-5 Archives - Chlorides-buliding-blocks

Alkhaibari, Ibrahim S. et al. published their research in Molecules in 2021 | CAS: 2613-34-5

3-Chloro-2,4-difluoroaniline (cas: 2613-34-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.SDS of cas: 2613-34-5

Synthesis of 3,5-Bis(trifluoromethyl)phenyl-Substituted Pyrazole Derivatives as Potent Growth Inhibitors of Drug-Resistant Bacteria was written by Alkhaibari, Ibrahim S.;Kc, Hansa Raj;Roy, Subrata;Abu-gazleh, Mohd. K.;Gilmore, David F.;Alam, Mohammad A.. And the article was included in Molecules in 2021.SDS of cas: 2613-34-5 This article mentions the following:

The design, synthesis, and antimicrobial studies of 30 novel pyrazole derivatives I (R = C₆H₅, 3-FC₆H₄, 3,4-(F₂)C₆H₃, etc.) have been described. Most of the synthesized compounds I are potent growth inhibitors of planktonic Gram-pos. bacteria with min. inhibitory concertation (MIC) values as low as 0.25渭g/mL. Further studies led to the discovery of several lead compounds, which are bactericidal and potent against MRSA persisters. Compounds I (R = 4-BrC₆H₄, 3,5-(Cl)₂-4-FC₆H₂, 4-Br-3-Cl-2-FC₆H₂) are potent against S. aureus biofilms with min. biofilm eradication concentration (MBEC) values as low as 1渭g/mL. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,4-difluoroaniline (cas: 2613-34-5SDS of cas: 2613-34-5).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Fang et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2018 | CAS: 2613-34-5

3-Chloro-2,4-difluoroaniline (cas: 2613-34-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Category: chlorides-buliding-blocks

Synthesis and antitumor activity of novel 6,7,8-trimethoxy N-aryl-substituted-4-aminoquinazoline derivatives was written by Liu, Fang;Huai, Ziyou;Xia, Guotai;Song, Liuping;Li, Sha;Xu, Yulan;Hong, Kangjun;Yao, Mingyue;Liu, Gang;Huang, Yinjiu. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.Category: chlorides-buliding-blocks This article mentions the following:

A series of 6,7,8-trimethoxy-N-aryl-substituted-4-aminoquinazoline derivatives, e.g., I, were synthesized as epidermal growth factor receptor (EGFR) inhibitors, and their antitumor activities were assessed in the gastric cancer cell line SGC7901 using MTT assay. All compounds were found to inhibit SGC7901 cell proliferation, and compound I (IC₅₀ = 0.434 μM) was found to be slightly more effective against SGC7901 cells than epirubicin (IC₅₀ = 5.16 μM). This suggests that compound I can be used as a new substitution structure to develop more efficacious antitumor agents. Western blot anal. showed that treatment with I (40 μM for 30 min) resulted in near complete inhibition of EGF-induced ERK1/2 phosphorylation, indicating that its anti-proliferative effect is largely associated with inhibition of ERK1/2 activation. These data imply that I is a potential anticancer agent capable of inhibiting cell proliferation. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,4-difluoroaniline (cas: 2613-34-5Category: chlorides-buliding-blocks).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

S-21 News The important role of 2613-34-5

The synthetic route of 2613-34-5 has been constantly updated, and we look forward to future research findings.

2613-34-5, name is 3-Chloro-2,4-difluoroaniline, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 3-Chloro-2,4-difluoroaniline

Et3N (0.19 mL, 1.35 mmol) was added to 3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid (146 mg, 0.46 mmol), HATU (218 mg, 0.57 mmol)2,4-difluoroaniline (119.8 mg, 0.92 mmol) in DMF (1 mL, 12.92 mmol) and stirred at 65Covernight. The solution was directly charged on a silica gel column and purified by column chromatography using a gradient from 10 till 100% EtOAc in heptane. The product fractions were concentrated and the residue was crystallised from methanol (10 mL) upon addition of water. The white crystals were filtered off and dried at 50C overnight, resulting in compound 312 (105 mg). Method D: Rt: 1.88 mm mlz: 428.0 (M-H) Exact mass: 429.1. Differentialscanning calorimetry: From 30 to 300 C at 10C/mm: peak at 179.4C.?H NMR (400 MHz, DMSO-d6) oe ppm 1.18 (d, J=7.0 Hz, 3 H), 3.81 (s, 3 H), 3.91 – 4.03 (m, 1 H), 7.07 – 7.14 (m, 1 H), 7.31 – 7.39 (m, 1 H), 7.54 (d, J=4.6 Hz, 1 H), 7.63 – 7.72 (m, 1 H), 8.59 (d, J=8.8 Hz, 1 H), 9.69 (s, 1 H).

The synthetic route of 2613-34-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN R&D IRELAND; VANDYCK, Koen; HACHE, Geerwin, Yvonne, Paul; LAST, Stefaan, Julien; MC GOWAN, David, Craig; ROMBOUTS, Geert; VERSCHUEREN, Wim, Gaston; RABOISSON, Pierre, Jean-Marie, Bernard; WO2014/184350; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

9/10/21 News Some tips on 2613-34-5

The synthetic route of 2613-34-5 has been constantly updated, and we look forward to future research findings.

Electric Literature of 2613-34-5, A common heterocyclic compound, 2613-34-5, name is 3-Chloro-2,4-difluoroaniline, molecular formula is C6H4ClF2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-chloro-7-fluoro-6-nitro-quinazoline (5g, 22.0 mmol) obtained in and 3-chloro-2,4-difluoro-aniline (5.39g, 33.0 mmol) were dissolved in 2-propanol (109 mL). The mixture was heated to 80C and further stirred for 4 hours. The mixture was cooled to room temperature, diluted with acetone (100 mL), and stirred for 10 min. The resulting mixture was filtered to the title compound as a solid (7.2 lg, 92%). NMR(300 MHz, CDC13):<5 9.62(s, 1H), 8.47(s, 1H), 7.95(d, 1H), 7.53(s, 1H),7.46(s, 1H)MS(ESI+, m/z): 355 [M+H]+ The synthetic route of 2613-34-5 has been constantly updated, and we look forward to future research findings. Reference:
Patent; HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup; WO2012/30160; (2012); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

September 7,2021 News Extended knowledge of 2613-34-5

The synthetic route of 3-Chloro-2,4-difluoroaniline has been constantly updated, and we look forward to future research findings.

Related Products of 2613-34-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2613-34-5, name is 3-Chloro-2,4-difluoroaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(R)- 1,5 -dimethyl-4-(N-( 1,1,1 -trifluoropropan-2- yl)sulfamoyl)-1H-pyrrole-2-carboxylic acid (450 mg, 1.43 mmol) and 3-chloro-4,5- difluoroaniline hydrochloride (0.57 g, 2.86 mmol) (synthesis described in synthesis for compound 57) and HATU (0.73 g, 1.91 mmol) were dissolved in DMF (2 mL) containingdiisopropylethylamine (0.82 mL, 4.77 mmol). The reaction mixture was stirred at 40C for 66 hours. The reaction mixture was directly loaded on column. The reaction mixture was purified using silica gel column chromatography (ethyl acetate in heptane from 20 to 80%). The desired fractions were combined and evaporated to keep 50 mL of solvent. The precipitates were filtered and washed with petroleum ether and dried in vacuum oven at 50C overnight to affordcompound 137 (490 mg) as white powder.(R)- 1,5 -dimethyl-4-(N-( 1,1,1 -trifluoropropan-2-yl)sulfamoyl)- 1 H-pyrrole-2-carboxylic acid (168mg, 0.53 mmol) (synthesis described in synthesis for compound 137) 5-amino-2-fluorobenzonitrile (0.15 g, 1.07 mmol) and HATU (0.24 g, 0.64 mmol) were dissolved in DMF (1 mL) containing diisopropylethylamine (0.23 mL, 1.34 mmol). The reaction mixture was stirred at 50C for 1 hour. The reaction mixture was purified using silica gel column chromatography (ethyl acetate in heptane from 20 to 80%). The desired fractions were combinedand evaporated to keep 50 mL of the solvent. The white solids were filtered and dried invacuum oven to afford compound 140 (180 mg) as white powder.Compound 143 (147 mg) as white powder was synthesized similarly as described for compound140 using 3-chloro-2,4-difluoroaniline (0.17 g, 1.07 mmol) instead of 5-amino-2-fluorobenzonitrile. The reaction mixture was stirred at 60C for 2 hours more. Method B; Rt:1.07 mi mlz: 458 (M-H) Exact mass: 459.04. ?H NMR (400 MHz, DMSO-d6) oe ppm 1.09 (d,J7.0 Hz, 3 H), 2.44 (s, 3 H), 3.82 (s, 3 H), 3.76 – 3.91 (m, 1 H), 7.34 (td, J=9.0, 2.0 Hz, 1 H),7.35 (s, 1 H), 7.52 (td, J8.7, 5.8 Hz, 1 H), 8.20 (br. s., 1 H), 10.05 (s, 1 H).

The synthetic route of 3-Chloro-2,4-difluoroaniline has been constantly updated, and we look forward to future research findings.

Some tips on 3-Chloro-2,4-difluoroaniline

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-2,4-difluoroaniline, other downstream synthetic routes, hurry up and to see.

Reference of 2613-34-5, The chemical industry reduces the impact on the environment during synthesis 2613-34-5, name is 3-Chloro-2,4-difluoroaniline, I believe this compound will play a more active role in future production and life.

3-Chloro-2,4-difluoro-(trifluoroacetamido)benzene. To a solution of 10.5 g (64.3 mmol) of 3-chloro-2,4-difluoroaniline in 25 mL of dioxane kept in an ice-bath was added dropwise 10 mL (14.8 g, 70.4 mmol) of trifluoroacetic anhydride. The solution was stirred at room temperature for 20 h. It was then added to 150 mL of ice-water and the mixture was stirred for 1 h. It was filtered, washed with water, and dried to leave an almost colorless solid 16.1 g (96%); mp 73-74 C.; 1 H NMR (CDCl3), 7.068 (m, 1), 7.976 (mb, 1), 8.146 (m, 1).

Reference:
Patent; State of Oregon, acting by and through the Oregon State Board of Higher Education, acting for and on behalf of the Oregon Health Sciences University and the University of Oregon, Eugene Oregon; Acea Pharmaceuticals, Inc.; The Regents of the University of California; US5631373; (1997); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Introduction of a new synthetic route about C6H4ClF2N

The synthetic route of 2613-34-5 has been constantly updated, and we look forward to future research findings.

Application of 2613-34-5,Some common heterocyclic compound, 2613-34-5, name is 3-Chloro-2,4-difluoroaniline, molecular formula is C6H4ClF2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxylic acid (250 mg, 1.02 mmol was dissolvedin CH3CN (15 mL). Triethylamine (0.56 mL), 3 -chloro-2,4-difluoroaniline (183 mg, 1.12 mmol) and HATU (463 mg, 1.22 mmol) were added. The reaction mixture was stirred at room temperature for 1 h, next at 50C for 80 h and then for 24 h at 75C. The solution was allowed to cool down. The solvent was evaporated leaving a yellow oil which was dissolved in CH2C12/MeOH (2 mL, 95:5) and purified by Flash Chromatography on silica using a gradient ofEtOAc-heptane 0/100 to 100/0]. The desired fractions were combined and the solvent was evaporated leaving a brown stable foam which was dissolved in a boiling mixture of of diisopropyl ether (3 mL) and CH3CN (0.5 mL). The solution was allowed to cool while stirring. The precipitate was filtered off, washed once with its own filtrate and with of diisopropyl ether (2 mL). The product was collected as a white solid and dried in vacuo at 50C, resulting incompound 172 (60 mg). Method B: Rt: 0.98 mm mlz: 390.1 (M-H) Exact mass: 391.06. ?H NMR (360 MHz, DMSO-d6) oe ppm 1.02 (d, J=6.6 Hz, 6 H), 3.26 (dd, J=13.4, 6.8 Hz, 1 H), 3.89 (s, 3 H), 7.25 (d, J=6.6 Hz, 1 H), 7.28 – 7.39 (m, 2 H), 7.48 – 7.59 (m, 2 H), 10.16 (s, 1 H).

The synthetic route of 2613-34-5 has been constantly updated, and we look forward to future research findings.

Analyzing the synthesis route of 2613-34-5

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2613-34-5, name is 3-Chloro-2,4-difluoroaniline, A new synthetic method of this compound is introduced below., name: 3-Chloro-2,4-difluoroaniline

Exapmle 35 (^-N-(4-((3-Chloro-2,4-difluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-((4aR,7aS)-tetrahydro- 2H-[l,4]dioxino[2,3-c]pyrrol-6( Step 1) N-(3-chloro-2,4-difluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine A solution of 4-chloro-7-fluoro-6-nitroquinazoline (10.00 g, 44.0 mmol) and 3-chloro-2,4-difluoroaniline (8.40 g, 51.5 mmol) in isopropanol (150 mL) was heated to 70 C and stirred for 5.0 hours. The reaction mixture was then cooled to 25C, and a yellow solid precipitated out. The mixture was filtered. The filtered cake was washed with isopropanol (50 mL) and dried under vacuum to give the title compound as a yellow solid (10.8 g, 69.2%). The compound was characterized by the following spectroscopic data: MS (ESI, pos.ion) m/z : 354.1 [M+H]+.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; LIU, Jinlei; ZHANG, Jiancun; ZHENG, Changchun; WO2014/177038; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The important role of 2613-34-5

The synthetic route of 2613-34-5 has been constantly updated, and we look forward to future research findings.

Some tips on 3-Chloro-2,4-difluoroaniline

The synthetic route of 2613-34-5 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 2613-34-5, A common heterocyclic compound, 2613-34-5, name is 3-Chloro-2,4-difluoroaniline, molecular formula is C6H4ClF2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.