Category: 26487-67-2

Some common heterocyclic compound, 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride, molecular formula is C8H17Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 26487-67-2

Compound 4 (200mg, 0.75mmol) refluxed with K2CO3 (259.42mg, 1.87mmol), 1-(2-Chloro-ethyl)-azepane hydrochloride (148.58mg, 0.75mmol) in acetone furnished 7 (220mg, 75percent) as brown viscous oil. 1H NMR (300MHz, CDCl3): delta 7.21?7.06 (m, 8H), 6.91?6.78 (m, 3H), 6.64?6.63 (m, 1H), 5.59 (s, 1H), 4.07 (t, J=6.0, 2H), 2.97 (t, J=6.1, 2H), 2.81 (t, J=5.6, 4H), 1.69?1.61 (m, 8H); 13C NMR (CDCl3, 50MHz): delta 157.5, 148.4, 144.1, 136.2, 129.8 (2C), 128.7 (2C), 128.4 (2C), 126.6, 126.5, 126.2, 124.4, 114.4 (2C), 65.7, 57.8, 54.9 (2C), 51.3, 25.7 (3C), 24.1; IR (Neat): 3019, 2938, 2362, 1610, 1509, 1218, 763cm?1; MS (ESI): m/z 392 (M+H)+; Anal. Calcd for C25H29NOS: C, 76.68; H, 7.46; N, 3.58. Found: C, 76.72; H, 7.39; N, 3.61.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 26487-67-2, its application will become more common.

Reference:
Article; Singh, Priyanka; Manna, Sudipta Kumar; Jana, Amit Kumar; Saha, Tiash; Mishra, Pankaj; Bera, Saurav; Parai, Maloy Kumar; Srinivas Lavanya Kumar; Mondal, Sankalan; Trivedi, Priyanka; Chaturvedi, Vinita; Singh, Shyam; Sinha, Sudhir; Panda, Gautam; European Journal of Medicinal Chemistry; vol. 95; (2015); p. 357 – 368;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26487-67-2, Formula: C8H17Cl2N

To a solution of 1,1-bis(4-hydroxyphenyl)-2-pentylhept-1-ene (30.0 mg, 85.1 mumol) in DMF (0.85 mL) at 0 ¡ãC was added 55percent sodium hydride (dispersion in paraffin liquid, 29.7 mg, 0.681 mmol). The reaction mixture was stirred for 15 min at 50 ¡ãC and then N-(2-chloroethyl)hexahydro-1H-azepine hydrochloride (55.6 mg, 0.281 mmol) was added in portions at room temperature. After the reaction mixture had been stirred for 3 h at 50 ¡ãC, saturated aqueous ammonium chloride was added at 0 ¡ãC. The mixture was extracted with dichloromethane and the organic layer was dried over sodium sulfate. After filtration of the mixture and evaporation of the solvent, the crude product was purified by thin layer chromatography on silica (eluant; ammoniacal chloroform/methanol = 9/1) to afford RID-F-S*17 (compound 17) (46.8 mg, 91percent) as an orange oil

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2-Chloroethyl)azepane hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Hasegawa, Makoto; Yasuda, Yukari; Tanaka, Makoto; Nakata, Kenya; Umeda, Eri; Wang, Yanwen; Watanabe, Chihiro; Uetake, Shoko; Kunoh, Tatsuki; Shionyu, Masafumi; Sasaki, Ryuzo; Shiina, Isamu; Mizukami, Tamio; European Journal of Medicinal Chemistry; vol. 71; (2014); p. 290 – 305;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-(2-Chloroethyl)azepane hydrochloride

To a solution of 2,2-bis(4-hydroxyphenyl)methylenecyclohexane (23.3 mg, 83.1 mumol) in DMF (0.83 mL) at 0 ¡ãC was added 55percent sodium hydride (dispersion in paraffin liquid, 29.1 mg, 0.667 mmol). The reaction mixture was stirred for 30 min at 50 ¡ãC and then N-(2-chloroethyl)hexahydro-1H-azepine hydrochloride (54.5 mg, 0.275 mmol) was added in portions at room temperature. After the reaction mixture had been stirred for 4 h at 50 ¡ãC, saturated aqueous ammonium chloride was added at 0 ¡ãC. The mixture was extracted with dichloromethane and the organic layer was dried over sodium sulfate. After filtration of the mixture and evaporation of the solvent, the crude product was purified by thin layer chromatography on silica (eluant; ammoniacal chloroform/methanol = 15/1) to afford RID-F-S*16 (compound 14) (32.0 mg, 73percent) as a yellow oil

The synthetic route of 1-(2-Chloroethyl)azepane hydrochloride has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hasegawa, Makoto; Yasuda, Yukari; Tanaka, Makoto; Nakata, Kenya; Umeda, Eri; Wang, Yanwen; Watanabe, Chihiro; Uetake, Shoko; Kunoh, Tatsuki; Shionyu, Masafumi; Sasaki, Ryuzo; Shiina, Isamu; Mizukami, Tamio; European Journal of Medicinal Chemistry; vol. 71; (2014); p. 290 – 305;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., category: chlorides-buliding-blocks

Compound b (8.5 mg, 18.9 mumol) was dissolved in DMF (0.4 mL), 55percent sodium hydride (8.3 mg, 0.189 mmol) was added, and the mixture was stirred at 50 ¡ã C. for 15 min. N- (2-chloroethyl) hexahydro-1 H-azepine hydrochloride (18.7 mg, 94.5 mumol) was added thereto and the mixture was stirred at 50 ¡ã C. for 12 hours. After cooling, reactionTo the mixture was added a saturated aqueous ammonium chloride solution to stop the reaction, and the mixture was extracted with methylene chloride. The organic layers were combined, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by thin layer chromatography (chloroform / methanol / ammonia = 90/3/2) to obtain compound c(10.2 mg, 75percent).

According to the analysis of related databases, 26487-67-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KANSAI BUNRI SOGOGAKUEN; TOKYO UNIVERSITY OF SCIENCE; HASEGAWA, MAKOTO; MIZUKAMI, TAMIO; TANAKA, MAKOTO; ISAMU, SHIINA; (82 pag.)JP2016/222659; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H17Cl2N

To a solution of 1,1-bis(4-hydroxyphenyl)-2-phenylethene (100 mg, 0.344 mmol) in DMF (3.44 mL) at 0 C was added 60% sodium hydride (dispersion in paraffin liquid, 82.6 mg, 2.07 mmol). The reaction mixture was stirred for 15 min at 50 C and then N-(2-chloroethyl)hexahydro-1H-azepine hydrochloride (222 mg, 1.12 mmol) was added in portions at room temperature. After the reaction mixture had been stirred for 4 h at 50 C, saturated aqueous ammonium chloride was added at 0 C. The mixture was extracted with dichloromethane and the organic layer was dried over sodium sulfate. After filtration of the mixture and evaporation of the solvent, the crude product was purified by thin layer chromatography on silica (eluant; ammoniacal chloroform/methanol = 30/1) to afford RID-F-S*1 (compound 13) (147 mg, 79%) as a brown oil

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Hasegawa, Makoto; Yasuda, Yukari; Tanaka, Makoto; Nakata, Kenya; Umeda, Eri; Wang, Yanwen; Watanabe, Chihiro; Uetake, Shoko; Kunoh, Tatsuki; Shionyu, Masafumi; Sasaki, Ryuzo; Shiina, Isamu; Mizukami, Tamio; European Journal of Medicinal Chemistry; vol. 71; (2014); p. 290 – 305;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 26487-67-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 26487-67-2 as follows.

Step 1.- 1-(2-(azepan-1-yl)ethyl)- -chloro-1 H-pyrazolo[3,4-d]pyrimidine. 1-(2-(azepan-1-yl)ethyl)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine (100 mg, 0.65 mmol) anh. DMF (2 mL) was added to a suspension of NaH (91 mg, 60percent dispersion mineral oil) in anh. DMF (3 mL) at 0 5C. The mixture was stirred at room temperature for 45 min. Then, 1 -(2-chloroethyl)azepane hydrochloride (192 mg, 0.97 mmol) in portions at -15 5C and was kept at this temperature for 3 h. The solvent was evaporated to dryness and the residue was diluted in ethyl ether, filtered and the solvent was removed under reduced pressure. The crude was purified by flash chromatography to give 1 -(2-(azepan-1 -yl)ethyl)-4-chloro-1 H-pyrazolo[3,4-d]pyrimidine (40 mg, 0.14 mmol, 22percent) as an oil.

According to the analysis of related databases, 26487-67-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; CUBERES-ALTISENT, Maria, Rosa; CORBERA-ARJONA, Jordi; DIAZ-FERNANDEZ, Jose, Luis; ALMANSA-ROSALES, Carmen; WO2013/10950; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 26487-67-2

Example 2: Synthesis of 2-((2-(azepan-1-yl)ethoxy)methyl)pyrazolo[1 ,5-a]pyridine maleate 0.12 g (3 mmol) of a 60percent NaH suspension in mineral oil were added under nitrogen to a solution of pyrazolo[1 ,5-a]pyridin-2-ylmethanol (100 mg, 0.67 mmol) in 5 mL of dry THF. The mixture was stirred for 5 h at room temperature, and after this time, was added 1 -(2-chloroethyl)azepane hydrochloride (201 mg, 1 .01 mmol) suspended in 8 ml_ of THF with 200muIota of triethylamine (TEA). The mixture was heated at 55 5C for 18 h, allowed to cool to room temperature, quenched with water and extracted with EtOAc, and washed with water. The organic layers were dried over Na2S04 and concentrated under vacuum to afford 0.22 g (65percent) of brown oil. Maleate salt was obtained following the same procedure as for example 1 . 1 H NMR (CDCI3) delta ppm: 8.42 (d, J = 6.8 Hz, 1 H), 7.52 (d, J = 8.8 Hz, 1 H), 7.20 – 7.06 (m, 1 H), 6.78 (t, J = 6.9 Hz, 1 H), 6.49 (s, 1 H), 6.30 (s, 2H), 4.74 (s, 2H), 4.08 – 3.89 (m, 2H), 3.70 – 3.51 (m, 2H), 3.36 – 3.25 (m, 2H), 3.19 – 2.99 (m, 2H), 2.15 – 1 .92 (m, 2H), 1 .92 – 1 .72 (m, 4H), 1 .72 – 1 .54 (m, 2H).

The synthetic route of 26487-67-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE S.A.; DIAZ FERNANDEZ, Jose Luis; CUBERES ALTISENT, Ma Rosa; WO2013/124341; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 26487-67-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 11: Synthesis of (4-(methylthio)phenyl)(naphthalen-l-yl)methanone 0-2-(azepan-l-yl)ethyl oxime oxalate (Compound 5h). Into a 50 ml round bottom flask, 4-(methylthio)phenyl (naphthalen-l-yl)methanone oxime (1 mmole, 293 mg), l-(2-Chloro-ethyl)-azepane hydrochloride (1.2 mmole, 237.6 mg), baked K2CO3 (5 mmole, 690 mg) and dry acetone (10.0 ml) were taken. The reaction mixture was refluxed under anhydrous conditions for 6 hours. The reaction was followed by TLC monitoring. After completion of the reaction, 2CO3 was filtered off and washed with acetone (2×10 ml). Filtrate was concentrated and the crude product was purified by basic alumina column chromatography using distilled Hexane to yield the pure product (350mg, 83.7percent). The product obtained was oily so a salt of the compound was prepared. Procedure for oxalate salt formation: Oxalic acid, 1 mmole/ 1 mmole of compound, (105.5 mg) and oily product (350 mg) were dissolved in dry methanol separately into two round bottom flasks. The acid and the compound were mixed and shaken thoroughly. The salt was precipitated using dry diethyl ether, filtered, washed with the same and collected. Yield: 427 mg, 78.49percent. M.P. (Oxalate Salt of compound) =145¡ã C; ESI MS(m/z)= 419 (M+H); ); IR(KBr, Cm-1): 3444.7, 2931.2, 2604.7, 1921.2, 1741.9, 1430.3, 1246.1, 1095.6, 1066.0, 961.0, 777.3; NMR(300MHz, CDCI3): delta= 7.93(d, J=8.2 Hz, 2H, ArH), 7.68(d, J=8.2 Hz, 1H, ArH), 7.58-7.39(m, 5H, ArH), 7.33-7.28(m, 1H, ArH), 7.18(d, J=8.6 Hz, 2H, ArH), 4.28(t, J=6.1 Hz, 2H, OCH2), 2.78(t, J=.5 Hz, 2H, NCH2), 2.51(m,. 4H, NCH2), 2.47(s, 3H, SCH3), 1.49(m, 8H, CH2); Analysis Calculated for C26H30N2OS (free base): C, 74.60; H, 7.22; N, 6.69, found: C, 74.62; H, 7.20; N, 6.68.

The chemical industry reduces the impact on the environment during synthesis 1-(2-Chloroethyl)azepane hydrochloride. I believe this compound will play a more active role in future production and life.

Reference:
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; SANYAL, Sabyasachi; KUMAR, Atul; CHATTOPADHYAY, Naibedya; LAL, Jawahar; TRIVEDI, Arun Kumar; DATTA, Dipak; RATH, Srikanta Kumar; AKHTAR, Tahseen; DWIVEDI, Shailendra Kumar Dhar; YADAV, Manisha; CHAKRAVARTI, Bandana; SINGH, Abhishek Kumar; MISHRA, Jay Sharan; SINGH, Nidhi; TRIPATHI, Anil Kumar; WO2015/29068; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1-(2-Chloroethyl)azepane hydrochloride

To a solution of 1,1-bis(4-hydroxyphenyl)-2,2-diphenylethene (27.2 mg, 74.6 mumol) in DMF (0.75 mL) at 0 ¡ãC was added 60percent sodium hydride (dispersion in paraffin liquid, 23.9 mg, 0.598 mmol). The reaction mixture was stirred for 15 min at 50 ¡ãC and then N-(2-chloroethyl)hexahydro-1H-azepine hydrochloride (48.8 mg, 0.246 mmol) was added in portions at room temperature. After the reaction mixture had been stirred for 1 h at 50 ¡ãC, saturated aqueous ammonium chloride was added at 0 ¡ãC. The mixture was extracted with dichloromethane and the organic layer was dried over sodium sulfate. After filtration of the mixture and evaporation of the solvent, the crude product was purified by thin layer chromatography on silica (eluant; ammoniacal chloroform/methanol = 30/1) to afford RID-F-S*14 (compound 10) (37.9 mg, 83percent) as a brown oil

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 26487-67-2.

Reference:
Article; Hasegawa, Makoto; Yasuda, Yukari; Tanaka, Makoto; Nakata, Kenya; Umeda, Eri; Wang, Yanwen; Watanabe, Chihiro; Uetake, Shoko; Kunoh, Tatsuki; Shionyu, Masafumi; Sasaki, Ryuzo; Shiina, Isamu; Mizukami, Tamio; European Journal of Medicinal Chemistry; vol. 71; (2014); p. 290 – 305;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A common compound: 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride, belongs to chlorides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 26487-67-2

To a suspension of 60percent sodium hydride (1.6 g) in N,N-dimethylformamide (50 ml) was added 4-bromophenol (3.0 g) under a nitrogen atmosphere, the solution was stirred for 10 minutes at room temperature, then 1-(2-chloroethyl)azepane hydrochloride (4.0 g) and sodium iodide (in catalytic amounts) were sequentially added thereto followed by stirring overnight at 80¡ãC. Water was added thereto followed by stirring, the solution was extracted with ethyl acetate, then sequentially washed with water and brine, and the solvent was evaporated in vacuo. The residue was purified by NH silica gel column chromatography (hexane-ethyl acetate system) to provide the title compound (5.0 g).1H-NMR (400MHz, CDCl3); delta (ppm): 1.58-1.67 (m, 8H), 2.73-2.79 (m, 4H), 2.93 (t, 2H), 4.02 (t, 2H), 6.79 (d, 2H), 7.36 (d, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 26487-67-2, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Eisai Co., Ltd.; EP1577288; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics