26487-67-2 Archives - Page 4 of 4 - Chlorides-buliding-blocks

Share a compound : 1-(2-Chloroethyl)azepane hydrochloride

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., 26487-67-2

To a solution of 1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene (26.4 mg, 83.4 mumol) in DMF (0.83 mL) at 0 ¡ãC was added 55percent sodium hydride (dispersion in paraffin liquid, 29.1 mg, 0.667 mmol). The reaction mixture was stirred for 15 min at 50 ¡ãC and then N-(2-chloroethyl)hexahydro-1H-azepine hydrochloride (54.5 mg, 0.275 mmol) was added in portions at room temperature. After the reaction mixture had been stirred for 3.5 h at 50 ¡ãC, saturated aqueous ammonium chloride was added at 0 ¡ãC. The mixture was extracted with dichloromethane and the organic layer was dried over sodium sulfate. After filtration of the mixture and evaporation of the solvent, the crude product was purified by thin layer chromatography on silica (eluant; ammoniacal chloroform/methanol = 15/1) to afford RID-F (compound 6) (37.3 mg, 79percent) as a pale yellow oil

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Hasegawa, Makoto; Yasuda, Yukari; Tanaka, Makoto; Nakata, Kenya; Umeda, Eri; Wang, Yanwen; Watanabe, Chihiro; Uetake, Shoko; Kunoh, Tatsuki; Shionyu, Masafumi; Sasaki, Ryuzo; Shiina, Isamu; Mizukami, Tamio; European Journal of Medicinal Chemistry; vol. 71; (2014); p. 290 – 305;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Analyzing the synthesis route of 26487-67-2

The synthetic route of 1-(2-Chloroethyl)azepane hydrochloride has been constantly updated, and we look forward to future research findings.

26487-67-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 1,1-bis(4-hydroxyphenyl)-2-butylhex-1-ene (69.1 mg, 0.213 mmol) in DMF (2.13 mL) at 0 ¡ãC was added 55percent sodium hydride (dispersion in paraffin liquid, 74.4 mg, 1.71 mmol). The reaction mixture was stirred for 15 min at 50 ¡ãC and then N-(2-chloroethyl)hexahydro-1H-azepine hydrochloride (139 mg, 0.702 mmol) was added in portions at room temperature. After the reaction mixture had been stirred for 3 h at 50 ¡ãC, saturated aqueous ammonium chloride was added at 0 ¡ãC. The mixture was extracted with dichloromethane and the organic layer was dried over sodium sulfate. After filtration of the mixture and evaporation of the solvent, the crude product was purified by thin layer chromatography on silica (eluant; ammoniacal chloroform/methanol = 30/1) to afford RID-F-S*23 (compound 18) (118 mg, 96percent) as an orange oil

The synthetic route of 1-(2-Chloroethyl)azepane hydrochloride has been constantly updated, and we look forward to future research findings.

Discovery of 26487-67-2

The synthetic route of 1-(2-Chloroethyl)azepane hydrochloride has been constantly updated, and we look forward to future research findings.

A common heterocyclic compound, 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride, molecular formula is C8H17Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 26487-67-2.

General procedure: A mixture of riccardin D, alkyl chloride hydrochloride and potassium carbonate in acetone was stirred under reflux for 24h. The insoluble material was then filtered off and the filtrate was concentrated to provide the residue that was purified by flash column chromatography, eluting with a gradient mixture of MeOH/ EtOAc/aqueous ammonia (93:5:2 to 80:18:2, V/V), to yield the pure product (compounds 17a-17f and 18a-18f) as a solid in good yield.

The synthetic route of 1-(2-Chloroethyl)azepane hydrochloride has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sun, Bin; Liu, Jun; Gao, Yun; Zheng, Hong-bo; Li, Lin; Hu, Qing-wen; Yuan, Hui-qing; Lou, Hong-xiang; European Journal of Medicinal Chemistry; vol. 136; (2017); p. 603 – 618;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Continuously updated synthesis method about 26487-67-2

The synthetic route of 26487-67-2 has been constantly updated, and we look forward to future research findings.

To a solution of 1,1-bis(4-hydroxyphenyl)-2-cyclohexyl-2-phenylethene (37.6 mg, 0.101 mmol) in DMF (1.02 mL) at 0 ¡ãC was added 60percent sodium hydride (dispersion in paraffin liquid, 24.4 mg, 0.610 mmol). The reaction mixture was stirred for 15 min at 50 ¡ãC and then N-(2-chloroethyl)hexahydro-1H-azepine hydrochloride (66.4 mg, 0.335 mmol) was added in portions at room temperature. After the reaction mixture had been stirred for 15.5 h at 50 ¡ãC, saturated aqueous ammonium chloride was added at 0 ¡ãC. The mixture was extracted with dichloromethane and the organic layer was dried over sodium sulfate. After filtration of the mixture and evaporation of the solvent, the crude product was purified by thin layer chromatography on silica (eluant; ammoniacal chloroform/methanol = 9/1) to afford RID-F-S*13 (compound 9) (51.9 mg, 83percent) as a pale yellow oil

The synthetic route of 26487-67-2 has been constantly updated, and we look forward to future research findings.