Category: 27841-33-4

Boddiboyena, Ramesh; Reddy, G. Nagendra; Seelam, Nareshvarma; Sarma, Monima; Gudisela, Mura reddy published the artcile< Design, synthesis, anticancer evaluation, molecular docking, and in silico ADME analysis of novel chalcones incorporated indole-pyrimidine derivatives as promising anticancer agents>, Application In Synthesis of 27841-33-4, the main research area is indolepyrimidine antitumor mol docking.

A novel library of aryl rings attached chalcone derivatives of indole-pyrimidines (10a-j) were designed, synthesized, and evaluated for anticancer activities against four human cancer cell lines such as PC3, DU-145 (prostate), A549 (lung), and MCF-7 (breast) by employing MTT method. The results of the MTT assay showed that all the synthetic compounds had some tumor cell growth inhibitory activities with IC50 values range from 0.01±0.005 μM to 14.6 ± 6.32 μM, and standard drug with values 1.97 ± 0.45 μM to 3.08 ± 0.135 μM, resp. Among them, compounds (10a, 10b, 10c, 10d, and 10e) displayed remarkable activities, and out of which compounds 10a and 10d were found to be the most promising with potential anti-cancer activity. Mol. docking studies of the compounds were carried out against SARM (PDB ID: 3V49) and the docking results exclusively proposed binding modes in the active site of SARM. Among all, 10a, 10b, 10d, 10 h and 10j showed comparable dock score, 10a and 10b (-142.89 and -145.13) displayed pronounced interactions when compared with co-crystal ligand (-143.40). Finally, in silico predictions of ADME and pharmacokinetic parameters indicated that all these compounds could be considered as drug candidates with oral bioavailability.

Chemical Data Collections published new progress about Antitumor agents. 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Application In Synthesis of 27841-33-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liger, Francois; Cadarossanesaib, Florence; Iecker, Thibaut; Tourvieille, Christian; Le Bars, Didier; Billard, Thierry published the artcile< 11C-Labeling: Intracyclic Incorporation of Carbon-11 into Heterocycles>, COA of Formula: C8H12N2O2, the main research area is carbon labeling intracyclic heterocycle cyclization.

Labeling of heterocycles with carbon-11 is generally performed through peripheral functionalizations and more scarcely inside heterocyclic core. Such less common approach usually requires preliminary multi-step synthesis of reactive species. Herein, a cyclization reaction by direct use of cyclotron-produced [11C]CO2 is described to obtain various heterocycles intracyclically labeled in only 10 min.

European Journal of Organic Chemistry published new progress about Cyclization. 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, COA of Formula: C8H12N2O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Boivin, Louis-Philippe; Dupont, William; Leclerc, Mario; Gendron, David published the artcile< Biosourced vanillin-based building blocks for organic electronic materials>, Recommanded Product: 4,5-Dimethoxybenzene-1,2-diamine, the main research area is benzo fused heterocycle preparation.

The preparation of compounds having a benzothiophene, indole, isatin, benzofuroxan, benzofurazan, benzothiadiazole, and phthalimide heteroaromatic ring structures were reported. More precisely, the results showed that vanillin can be used as a biosourced starting material for the preparation of a variety of aromatic dibrominated monomers. X-ray crystallog. on single crystals was also performed to obtain meaningful information on their solid-state ordering. This work opens the way to new sustainable, biosourced aromatic materials (small mols. or polymers) for organic electronics.

Journal of Organic Chemistry published new progress about Benzaldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Recommanded Product: 4,5-Dimethoxybenzene-1,2-diamine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jun, Joonhong; Baek, Jihyun; Yang, Songyi; Moon, Hyungwoo; Kim, Hyejin; Cho, Hyunwook; Hah, Jung-Mi published the artcile< Discovery of a Potent and Selective JNK3 Inhibitor with Neuroprotective Effect Against Amyloid β-Induced Neurotoxicity in Primary Rat Neurons>, Quality Control of 27841-33-4, the main research area is amyloid beta neurotoxicity Jun terminal kinase inhibitor neuroprotective effect; Alzheimer’s disease (AD); JNK3; SAR; benzimidazole; neurodegenerative diseases; neuroprotection.

As members of the MAPK family, c-Jun-N-terminal kinases (JNKs) regulate the biol. processes of apoptosis. In particular, the isoform JNK3 is expressed explicitly in the brain at high levels and is involved in the pathogenesis of neurodegenerative diseases such as Alzheimer′s disease (AD) and Parkinson′s disease (PD). In this study, we prepared a series of five 6-dihydroxy-1H-benzo[d]imidazoles as JNK3 inhibitors and found them have potential as neuroprotective agents. Following a previous lead scaffold, benzimidazole moiety was modified with various aryl groups and hydroxylation, and the resulting compounds exhibited JNK3 inhibitory activity with improved potency and selectivity. Out of 37 analogs synthesized, (S)-cyclopropyl(3-((4-(2-(2,3-dihydrobenzo[b][1,4]dioxin -6-yl)-5,6-dihydroxy-1H-benzo[d]imidazol-1-yl)pyrimidin-2-yl)amino) piperidin-1-yl)methanone (35b) demonstrated the highest JNK3 inhibition (IC50 = 9.7 nM), as well as neuroprotective effects against Aβ-induced neuronal cell death. As a protein kinase inhibitor, it also showed excellent selectivity over other protein kinases including isoforms JNK1 (>1000 fold) and JNK2 (-10 fold).

International Journal of Molecular Sciences published new progress about Cell viability. 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Quality Control of 27841-33-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dejouy, Garance; Renault, Kevin; Bonnin, Quentin; Chevalier, Arnaud; Michaudet, Cedric; Picquet, Michel; Valverde, Ibai E.; Romieu, Anthony published the artcile< Fluorogenic Enzyme-Triggered Domino Reactions Producing Quinoxalin-2(1H)-one-based Heterocycles>, Synthetic Route of 27841-33-4, the main research area is fluorogenic quinoxalin heterocycle enzyme triggered.

A simple and effective biocompatible domino reaction triggered by a model protease and leading to the formation of strongly fluorescent quinoxalin-2(1H)-one N-heterocycles is described. Some pos. attributes including versatility and the ability to provide outstanding fluorescence “”OFF-ON”” responses were revealed by this work. They open the way for practical applications of this novel type of “”covalent-assembly””-based fluorescent probe in the fields of sensing and bioimaging.

Organic Letters published new progress about Confocal microscopy. 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Synthetic Route of 27841-33-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shee, Sujan; Panja, Dibyajyoti; Kundu, Sabuj published the artcile< Nickel-Catalyzed Direct Synthesis of Quinoxalines from 2-Nitroanilines and Vicinal Diols: Identifying Nature of the Active Catalyst>, Computed Properties of 27841-33-4, the main research area is nitroaniline benzenediamine vicinal diol nickel dehydrogenative coupling cyclocondensation catalyst; quinoxaline preparation.

The inexpensive and simple NiBr2/1,10-phenanthroline system-catalyzed synthesis of a series of quinoxalines from both 2-nitroanilines and 1,2-diamines is demonstrated. The reusability test for this system was performed up to the seventh cycle, which afforded good yields of the desired product without losing its reactivity significantly. Notably, during the catalytic reaction, the formation of the heterogeneous Ni-particle was observed, which was characterized by PXRD, XPS, and TEM techniques.

Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent) (nitro). 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Computed Properties of 27841-33-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Wenyuan; Chen, Hongjin; Yue, Youfeng; Zhang, Rui; Liu, Jian published the artcile< Electropolymerization of V-shape D-A-D type monomers for efficient and tunable electrochromics>, Recommanded Product: 4,5-Dimethoxybenzene-1,2-diamine, the main research area is electrochromic triphenylamine quinoxaline derivative preparation electrochem polymerization.

Five novel donor-acceptor-donor (D-A-D) type monomers (VQ1 ∼ VQ5) with a common V-shape configuration have been developed and further electropolymerized for electrochromic applications. The monomers were designed by introducing two triphenylamine groups into the 2- and 3- position of the quinoxaline derivates, resp. These redox-active monomers could be electrodeposited robustly on the ITO electrodes in an electrolyte solution via the oxidative coupling reactions between triphenylamine radical cations. The obtained thin polymer films (PVQ1 ∼ PVQ5) exhibited reversible redox behaviors and obvious color changes upon voltage variation. All these polymers exhibited excellent electrochromic performances involving high optical contrast (over 70%), short response time (less than 2 s) and high coloration efficiency (over 200 cm2 C-1). Moreover, the optical properties of these polymers in both neutral state and oxidation state can be tuned by variation of the addnl. substituents on the quinoxaline parts, resp.

Dyes and Pigments published new progress about Absorption spectra. 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Recommanded Product: 4,5-Dimethoxybenzene-1,2-diamine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cevher, Sevki Can; Hizalan, Gonul; Alemdar Yilmaz, Eda; Cevher, Duygu; Udum Arslan, Yasemin; Toppare, Levent; Yildirim, Erol; Cirpan, Ali published the artcile< A comprehensive study: Theoretical and experimental investigation of heteroatom and substituent effects on frontier orbitals and polymer solar cell performances>, Electric Literature of 27841-33-4, the main research area is benzochalcogendiazole polymer solar cell electronic optical photovoltaic property.

Benzochalcogendiazole derivatives are incorporated with thieno[3,4-c]pyrrole-4,6-dione (TPD) acceptor and 4,8-diethoxybenzo[1,2-b:4,5-b′]dithiophene donor to synthesize tree-component random copolymers. Four different copolymers are synthesized and their electronic, optical and photovoltaic properties are compared. Comparisons are aligned in the course of two different strategies, which are the replacement of benzochalcogendiazole moiety and the modification of side group on benzothiadiazole. Theor. calculations by comparing the HOMO-LUMO levels, band gaps and other electronic descriptors of pristine and 2 + 2 two acceptor-based copolymers are investigated. Random copolymer bearing benzoxadiazole moiety, PO exhibits the highest photovoltaic performance of 8.29% with a Jsc of 14.96 mA cm-2, Voc of 0.87 V, fill factor (FF) of 63.70%. PF possesses the highest Voc with a value of 0.88 V, Jsc of 14.40 mA cm-2, power conversion efficiency (PCE) of 7.32% with 58% FF. PS exhibits average feature with Jsc 11.82 mA cm-2, Voc 0.80 V, FF 50%, and 4.72% PCE. Lowest performing selenadiazole containing random copolymer (PSe) copolymer exhibits maximum PCE as 3.65%. These results demonstrate the promising effectiveness of benzoxadiazole selection as an alternative acceptor unit and F atom substitution for the design of (A1-D)-(A2-D) type random copolymers for organic solar cells.

Journal of Polymer Science (Hoboken, NJ, United States) published new progress about Adiabatic electron affinity. 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Electric Literature of 27841-33-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics