Category: 29027-17-6

Sources of common compounds: C7H8ClN

Statistics shows that 2-Chloro-3-methylaniline is playing an increasingly important role. we look forward to future research findings about 29027-17-6.

Application of 29027-17-6, These common heterocyclic compound, 29027-17-6, name is 2-Chloro-3-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-Chloro-1-isothiocyanato-3-methylbenzene To 2-chloro-3-methylaniline (1 equiv.) in DCM/water (0.5 M, 1/2) at 0 C. was added NaOH (3 equiv.), the solution was stirred at 0 C. for 5 min, then CSCl2 (3 equiv.) was added. The reaction was stirred at room temperature overnight. The reaction was extracted with DCM. The combined organic layers were concentrated to dryness to give crude 2-chloro-1-isothiocyanato-3-methylbenzene. The crude product was purified by column chromatography on silica gel with petroleum ether to give 2-chloro-1-isothiocyanato-3-methylbenzene (61%) as a colorless oil. 1H NMR (400 MHz, CDCl3) delta ppm: 7.19-7.09 (m, 3H), 2.42 (s, 3H).

Statistics shows that 2-Chloro-3-methylaniline is playing an increasingly important role. we look forward to future research findings about 29027-17-6.

Reference:
Patent; Signal Pharmaceuticals, LLC; Alexander, Matthew; Bahmanyar, Sogole; Hansen, Joshua; Huang, Dehua; Hubbard, Robert; Jeffy, Brandon; Leisten, Jim; Moghaddam, Mehran; Raheja, Raj K.; Raymon, Heather; Schwarz, Kimberly; Sloss, Marianne; Torres, Eduardo; Tran, Tam Minh; Xu, Shuichan; Zhao, JingJing; Boylan, John Frederick; (317 pag.)US2016/96841; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some tips on C7H8ClN

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-3-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference of 29027-17-6, The chemical industry reduces the impact on the environment during synthesis 29027-17-6, name is 2-Chloro-3-methylaniline, I believe this compound will play a more active role in future production and life.

a (2-Chloro-3-methyl-phenyl)-hydrazine The title compound was prepared in accordance with the general method of example 25a) from 2-chloro-3-methylaniline.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-3-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bentley, Jonathan M.; Hebeisen, Paul; Muller, Marc; Richter, Hans; Roever, Stephan; US2002/35110; (2002); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics