Category: 29027-20-1

Reddy, M. Thirupalu; Reddy, V. Hanuman; Reddy, R. Chenna Krishna; Reddy, V. Krishna; Reddy, Y. V. Rami published the artcile< Synthesis and molecular docking studies of new substituted indazole derivatives for anti-breast cancer activity>, Electric Literature of 29027-20-1, the main research area is substituted indazolyl ethyl acetate preparation mol docking anticancer.

A series of new substituted 2H-indazolyl-ethylacetate derivatives I [R1 = H, 4-Cl, 5-Cl, 6-Cl, 7-Cl; R2 = H, 4-NH2, 5-NH2, 6-NH2, 7-NH2] were synthesized and studied for their mol. docking properties. The study showed that, compounds I were found to have good anti-breast cancer activity and most of them interact with active site residues of aromatase enzyme. Addnl., I [R1 = 5-Cl; R2 = H] showed highest binding energy of -8.0 kcal/mol and formed contacts with the NH1 and NH2 atoms of Arg115 by the distance of 3.3 ° and 3.2 ° resp.

Pharma Chemica published new progress about Antitumor agents. 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Electric Literature of 29027-20-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

El-Zahraa, F.; El-Basil, S.; El-Sayed, M.; Ghoneim, K. M.; Khalifa, M. published the artcile< Synthesis and pharmacological screening of certain N-substituted amides structurally related to some local anesthetics>, Product Details of C7H8ClN, the main research area is anesthesia pivalamide diphenylacetamide; pivalamide preparation anesthetic; diphenylacetamide preparation anesthetic.

Eighteen Ph2CHCONHR (I; R = e.g., 2,6-, 2,5-, 2,4-, 3,4-, 3,5-Me2C6H3, 4,5-MeClC6H3, 4-O2NC6H4) and 14 Me3CCONHR1 (II; R1 = e.g., 3,6-Me2C6H3, 3-pyridyl, 4-nitro-2-pyridyl) were prepared in 45-90% yield by reaction of the acid chloride with the resp. amine. The most active intradermal anesthesia in guinea pigs was I (R = 4-methyl-5-chlorophenyl); its activity was more than double that of procaine hydrochloride. As a corneal anesthetic II (R1 = 2,6-Me2C6H3) was the most active anesthetic and for plexus anesthesia I (R = 2,6-Me2C6H3) was the most active.

Pharmazie published new progress about Anesthetics. 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Product Details of C7H8ClN.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sun, Bin; Shi, Xiayue; Zhuang, Xiaohui; Huang, Panyi; Shi, Rongcheng; Zhu, Rui; Jin, Can published the artcile< Photoinduced EDA Complexes Enabled Radical Tandem Cyclization/Arylation of Unactivated Alkene with 2-Amino-1,4-naphthoquinones>, Category: chlorides-buliding-blocks, the main research area is oxopyrrolidinyl arylamino naphthalenedione preparation photochem regioselective green chem; amino naphthoquinone allyl bromo difluoroacetamide cyclization arylation EDA complex.

A visible-light-induced radical tandem cyclization/arylation between 2-amino-1, 4-naphthoquinone and N-allyl-2-bromo-2,2-difluoroacetamides has been developed without an external photocatalyst. The transformation could be carried out at room temperature and gave a variety of C-3-functionalized 2-amino-1,4-naphthoquinone derivatives I (R1 = Ph, 4-MeOC6H4, 2-MeC6H4, etc.; R2 = H, 4-i-Pr, 3-Br, etc.) in moderate to excellent yields. Moreover, mechanistic studies revealed that the reaction is driven by the formation of an electron donor-acceptor (EDA) complex.

Organic Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sun, Bin; Shi, Xiayue; Zhuang, Xiaohui; Huang, Panyi; Shi, Rongcheng; Zhu, Rui; Jin, Can published the artcile< Photoinduced EDA Complexes Enabled Radical Tandem Cyclization/Arylation of Unactivated Alkene with 2-Amino-1,4-naphthoquinones>, Category: chlorides-buliding-blocks, the main research area is oxopyrrolidinyl arylamino naphthalenedione preparation photochem regioselective green chem; amino naphthoquinone allyl bromo difluoroacetamide cyclization arylation EDA complex.

A visible-light-induced radical tandem cyclization/arylation between 2-amino-1, 4-naphthoquinone and N-allyl-2-bromo-2,2-difluoroacetamides has been developed without an external photocatalyst. The transformation could be carried out at room temperature and gave a variety of C-3-functionalized 2-amino-1,4-naphthoquinone derivatives I (R1 = Ph, 4-MeOC6H4, 2-MeC6H4, etc.; R2 = H, 4-i-Pr, 3-Br, etc.) in moderate to excellent yields. Moreover, mechanistic studies revealed that the reaction is driven by the formation of an electron donor-acceptor (EDA) complex.

Organic Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formenti, Dario; Topf, Christoph; Junge, Kathrin; Ragaini, Fabio; Beller, Matthias published the artcile< Fe2O3/NGr@C- and Co-Co3O4/NGr@C-catalysed hydrogenation of nitroarenes under mild conditions>, Application of C7H8ClN, the main research area is aniline preparation green chem chemoselective; nitroarene hydrogenation reaction doped graphene iron cobalt nanocatalyst.

An improved hydrogenation of nitroarenes such as nitrobenzene, 2-nitrobiphenyl, 2,4,6-tri-t-butylnitrobenzene, etc. using nano-structured iron- and cobalt-based catalysts has been presented. Modifications of the heterogeneous catalysts by N-doped graphene-flakes are crucial for the success of selective reductions The use of polar solvents and basic additives has a significant pos. influence on the rate of reduction of nitroarenes. This allows performing non-noble metal-catalyzed hydrogenations under very mild reaction conditions (e.g. 70 °C and 20 bar). On the basis of the obtained catalytic results a heterolytic mechanism for the hydrogenation process is postulated, too.

Catalysis Science & Technology published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Application of C7H8ClN.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ivachtchenko, Alexandre V.; Golovina, Elena S.; Kadieva, Madina G.; Koryakova, Angela G.; Kovalenko, Sergiy M.; Mitkin, Oleg D.; Okun, Ilya M.; Ravnyeyko, Irina M.; Tkachenko, Sergey E.; Zaremba, Oleg V. published the artcile< Synthesis and biological study of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines as potent and selective serotonin 5-HT6 receptor antagonists>, Recommanded Product: 3-Chloro-5-methylaniline, the main research area is serotonin 5HT6 antagonist triazolopyrimidine preparation structure activity combinatorial library.

A number of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines were prepared and their 5-HT6 receptor binding affinity and ability to inhibit the functional cellular responses to serotonin were evaluated. 3-[(3-Chlorophenyl)sulfonyl]-N-(tetrahydrofuran-2-ylmethyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine 2{5,26} appeared to be the most active in a functional assay (IC50 = 29.0 nM) and 3-(phenylsulfonyl)-N-(2-thienylmethyl) thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine 2{1,28} demonstrated the greatest affinity in a 5-HT6 receptor radioligand binding assay (K i = 1.7 nM). A screening of 5-HT2A and 5-HT2B receptor affinity revealed that 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines are highly selective 5-HT6 receptor ligands.

Bioorganic & Medicinal Chemistry published new progress about 5-HT1A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (antagonists). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Recommanded Product: 3-Chloro-5-methylaniline.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Emokpae, Thomas A.; Eguavuen, Osa; Hirst, Jack published the artcile< The kinetics of the reactions of picryl chloride, with some substituted anilines. Part 5>, Synthetic Route of 29027-20-1, the main research area is picryl chloride substitution aniline kinetics; substituent effect aniline substitution; additivity aniline substitution picryl.

Arrhenius parameters were determined for the reactions of picryl chloride in MeCN with 3,5-RR1C6H3NH2 [R = H2N, Me, R1 = H; R = H2N, R1 = O2N (I); R = F, R1 = MeSO2; R = NO2, OMe, Me, F, Cl, Br, iodo, R1 = Me; R = R1 = F, Cl, Br, iodo]. A total of 33 3,5-disubstituted anilines was examined for the additivity of substituent effects on the free energy of activation, and, with the exception of I, this hypothesis reproduces exptl. rate constants within a factor of 2. A rationalization is proposed for the deviations that occur in some cases when more stringent criteria of additivity are used.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about Additivity. 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Synthetic Route of 29027-20-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shi, Hang; Wang, Peng; Suzuki, Shin; Farmer, Marcus E.; Yu, Jin-Quan published the artcile< Ligand Promoted meta-C-H Chlorination of Anilines and Phenols>, Synthetic Route of 29027-20-1, the main research area is regioselective chlorination aniline phenol norbornene mediator.

Pd-Catalyzed meta-C-H chlorination of anilines and phenols was developed using norbornene as the mediator. Heterocycles, including indole, thiophene, and indazole, are tolerated. The identification of a new pyridone-based ligand, I (R = CF3, cyano), was crucial for the success of this meta-C-H chlorination reaction. Subsequent diverse transformations of the chlorinated products demonstrate the versatility of meta-C-H chlorination.

Journal of the American Chemical Society published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Synthetic Route of 29027-20-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cao, Xiufang; Xu, Shengzhen; Li, Xuegang; Shen, Xiaoxia; Zhang, Qingye; Li, Jianhong; Chen, Changshui published the artcile< N-nitrourea derivatives as novel potential fungicides against Rhizoctonia solani: synthesis, antifungal activities, and 3D-QSAR>, Application In Synthesis of 29027-20-1, the main research area is antifungal nitrourea derivative.

N-nitrourea derivatives bearing various aryl substituents were obtained via three steps, including nitration, carbamic chlorination, and aminolysis reactions. The structures of all the newly synthesized compounds were characterized and confirmed by IR, 1H-NMR, MS, and elemental anal. Bioassays indicated that five of the compounds possess fungicidal activity against Rhizoctonia solani. Structure-activity relationship (SAR) is also discussed based on the exptl. data, and the further quant. structure-activity relationship (QSAR) was analyzed using comparative mol. field anal. and comparative mol. similarity indexes anal.

Chemical Biology & Drug Design published new progress about Fungicides (antifungal). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Application In Synthesis of 29027-20-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Khadse, Saurabh C.; Chatpalliwar, Vivekananda A. published the artcile< Synthesis of benzamides by microwave assisted ring opening of less reactive dimethylaminobenzylidene oxazolone>, HPLC of Formula: 29027-20-1, the main research area is dimethylaminobenzylidene oxazolone amine microwave irradiation ring opening; benzamide preparation.

The synthesis of some benzamide compounds by microwave-assisted ring opening of 4-(4-dimethylaminobenzylidene)-2-phenyl-5-oxazolone was presented. By conventional synthesis involving heating, it was found difficult to obtain ring-opened products, probably due to poor tendency of the carbonyl carbon (C5) of oxazolone derivative to undergo nucleophilic attack by mono/or disubstituted anilines. Microwave assisted reactions were easy to perform, have reduced the reaction time and produced good yields.

Arabian Journal of Chemistry published new progress about Benzamides Role: SPN (Synthetic Preparation), PREP (Preparation). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, HPLC of Formula: 29027-20-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics