Category: 2905-24-0

Chlorinated organic compounds are found in nearly every class of biomolecules. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Name: 3-Bromobenzenesulfonyl chloride.

Nepali, Kunal;Hsu, Tsung-I.;Hsieh, Chien-Ming;Lo, Wei-Lun;Lai, Mei-Jung;Hsu, Kai-Cheng;Lin, Tony Eight;Chuang, Jian-Ying;Liou, Jing-Ping research published 《 Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma》, the research content is summarized as follows. The anti-GBM drug pipeline, which is hurdled and marred by the notorious nature of glioblastomas in terms of resistance to therapy and limited drug delivery into the brain is required to be loaded with mechanistically diverse agents. The consideration of HDAC inhibition as a prudent approach to circumvent the resistance issue in GBM spurred to pragmatically design and synthesize of hydroxamic acids, e.g., I endowed with CNS penetrating ability was developed. By virtue of the blood brain barrier permeability, memantine was envisioned as an appropriate CAP component for the construction of the HDAC inhibitors. Diverse linkers were stapled for the tetheration of the zinc binding motif with the CAP group to pinpoint an appropriate combination that could confer inhibitory preference to HDAC6 isoform (overexpressed in GBM). Resultantly, hydroxamic acid like N-(4-{[(3,5-dimethyladamantan-1-yl)amino]methyl}phenyl)-N’-hydroxyoctanediamide (II) was identified as a promising compound that elicited striking antiproliferative effects against Human U87MG GBM cells as well as TMZ-resistant GBM cells and P1S cells, a concurrent chemo radiotherapy-resistant/patient-derived glioma cell line mediated through preferential HDAC6 inhibition (IC₅₀ = 5.42 nM). The II exerted cell cycle arrest at G2 phase, induced apoptosis in GBM cells at high concentration and exhibited high BBB permeability. To add on, in-vivo study revealed that the administration of compound II prolonged the survival of TMZ-resistant U87MG inoculated orthotopic mice. Overall, the cumulative results indicate that II is a tractable CNS penetrant preferential HDAC6 inhibitor that might emerge as a potent weapon against GBM.

Name: 3-Bromobenzenesulfonyl chloride, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., 2905-24-0.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Electric Literature of 2905-24-0.

Michelet, Bastien;Castelli, Ugo;Appert, Emeline;Boucher, Maude;Vitse, Kassandra;Marrot, Jerome;Guillard, Jerome;Martin-Mingot, Agnes;Thibaudeau, Sebastien research published 《 Access to Optically Pure Benzosultams by Superelectrophilic Activation》, the research content is summarized as follows. Through superacid activation, N-(arenesulfonyl)-amino alcs. derived from readily available ephedrines or amino acids undergo an intramol. Friedel-Crafts reaction to afford enantiopure benzosultams bearing two adjacent stereocenters in high yields with fully controlled diastereoselectivity. Low-temperature NMR spectroscopy demonstrated the crucial role played by the conformationally restricted chiral dicationic intermediates.

2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., Electric Literature of 2905-24-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Related Products of 2905-24-0.

Miao, Chun-Bao;Zheng, An-Qi;Zhou, Li-Jin;Lyu, Xinyu;Yang, Hai-Tao research published 《 Copper-Catalyzed Annulation of Oxime Acetates with α-Amino Acid Ester Derivatives: Synthesis of 3-Sulfonamido/Imino 4-Pyrrolin-2-ones》, the research content is summarized as follows. A copper-catalyzed annulation of oxime acetates and α-amino acid ester derivatives for the easy preparation of 4-pyrrolin-2-ones bearing a 3-amino group was developed. This process features the oxidation of amines with oxime esters as the internal oxidant to produce the active 1,3-dinucleophilic and 1,2-dielectrophilic species concurrently. The subsequent nucleophilic cyclization realized the efficient construction of 4-pyrrolin-2-one derivatives

2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., Related Products of 2905-24-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. HPLC of Formula: 2905-24-0.

Mayer, Nicole;Schweiger, Martina;Fuchs, Elisabeth;Migglautsch, Anna K.;Doler, Carina;Grabner, Gernot F.;Romauch, Matthias;Melcher, Michaela-Christina;Zechner, Rudolf;Zimmermann, Robert;Breinbauer, Rolf research published 《 Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL)》, the research content is summarized as follows. High serum fatty acid (FA) levels are causally linked to the development of insulin resistance, which eventually progresses to type 2 diabetes and non-alc. fatty liver disease (NAFLD) generalized in the term metabolic syndrome. Adipose triglyceride lipase (ATGL) is the initial enzyme in the hydrolysis of intracellular triacylglycerol (TG) stores, liberating fatty acids that are released from adipocytes into the circulation. Hence, ATGL-specific inhibitors have the potential to lower circulating FA concentrations, and counteract the development of insulin resistance and NAFLD. In this article, we report about structure-activity relationship (SAR) studies of small mol. inhibitors of murine ATGL which led to the development of Atglistatin. Atglistatin is a specific inhibitor of murine ATGL, which has proven useful for the validation of ATGL as a potential drug target.

HPLC of Formula: 2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., 2905-24-0.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Application of C6H4BrClO2S.

Ma, Qiang;Li, Ming;Chen, Zhuo;Ni, Shao-Fei;Wright, James S.;Wen, Li-Rong;Zhang, Lin-Bao research published 《 An approach for the synthesis of 2-aryl-3-sulfonyl substituted quinolines through an electrochemical cascade annulation pathway》, the research content is summarized as follows. An electrochem. protocol for the synthesis of 2,3-disubstituted quinolines I (R = H, Me, Br, Cl, etc.; R¹ = H, Me, F; R² = Ph, 2-chlorophenyl, thiophen-2-yl, etc.; R³ = Ph, 3-bromophenyl, 4-cyclohexylphenyl, etc.) by reacting benzoxazinones II with arylsulfonyl hydrazides R³S(O)₂NHNH₂ was established under simple and mild conditions (room temperature and an undivided cell). The methodol. does not require noble catalysts or external oxidants, providing a green and mild pathway for de novo synthesis of functional quinolines I with excellent regioselectivity. Moreover, the method tolerated a variety of functional groups. Notably, the scaled-up experiment and follow-up procedures demonstrate the practicality of electrochem. synthesis.

Application of C6H4BrClO2S, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., 2905-24-0.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. SDS of cas: 2905-24-0.

Lv, Yunhe;Han, Wanru;Pu, Weiya;Xie, Jinhui;Wang, Axue;Zhang, Mengyue;Wang, Jin;Lai, Junrong research published 《 Copper-catalyzed regioselective 1,4-sulfonylcyanation of 1,3-enynes with sulfonyl chlorides and TMSCN》, the research content is summarized as follows. A novel and practical copper-catalyzed reaction for the 1,4-sulfonylcyanation of 1,3-enynes under mild conditions was described. This protocol provided efficient and straightforward access to a variety of 5-sulfonylpenta-2,3-dienenitrile derivatives with excellent functional group tolerance and good regioselectivity from readily available 1,3-enynes and com. available sulfonyl chlorides and TMSCN. A mechanism involving sulfonyl and allenyl radical species was proposed.

SDS of cas: 2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., 2905-24-0.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Synthetic Route of 2905-24-0.

Luo, Ziwei;Yang, Xinkan;Tsui, Gavin Chit research published 《 Perfluoroalkylation of Thiosulfonates: Synthesis of Perfluoroalkyl Sulfides》, the research content is summarized as follows. A practical synthesis of perfluoroalkyl sulfides is described. The method employs stable and readily accessible thiosulfonates as new electrophiles with com. nucleophilic perfluoroalkylating reagents. The mild reaction conditions allow access to a wide variety of both aryl- and alkyl-substituted perfluoroalkyl sulfides amenable to pharmaceutical development. Furthermore, the reaction operation is straightforward, odorless, does not produce toxic wastes, and, therefore should appeal to practitioners in industrial-scale productions.

2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., Synthetic Route of 2905-24-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Application of C6H4BrClO2S.

Luo, Xu;Wang, Shengchun;Lei, Aiwen research published 《 Electrochemical-Induced Hydroxysulfonylation of α-CF₃ Alkenes to Access Tertiary β-Hydroxysulfones》, the research content is summarized as follows. An electrochem. hydroxysulfonylation of α-CF₃ alkenes RC(=CH₂)CF₃ (R = 4-CH₃OC₆H₄, 2,3-dihydro-1,4-benzodioxin-6-yl, naphthalen-2-yl, etc.) was accomplished in this work. By using easily available sodium sulfinates R¹SO₂Na (R¹ = Me, Ph, cyclopropyl, etc.) as the sulfonylating agents, a series of valuable α-trifluoromethyl tertiary alcs. RC(OH)CF₃CH₂S(O)₂R¹ was synthesized under mild and environmentally friendly electrolysis conditions in moderate to good yields. The preliminary mechanistic investigation indicates that this difunctional reaction involves a radical process via a sulfonyl radical. Gram-scale synthesis shows the significant potential application of this protocol.

Application of C6H4BrClO2S, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., 2905-24-0.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Related Products of 2905-24-0.

Luo, Lihua;Tang, Juan;Sun, Rui;Li, Wenjing;Zheng, Xueli;Yuan, Maoling;Li, Ruixiang;Chen, Hua;Fu, Haiyan research published 《 Direct C-H Sulfonylimination of Pyridinium Salts》, the research content is summarized as follows. A direct pyridinium C-H sulfonylimination has been developed for the synthesis of sulfonyl iminopyridine derivatives I (R = H, CN, Ph, thiophen-2-yl, etc.; R¹ = H, OMe, Ph, thiophen-3-yl, etc.; R² = H, cyclopropyl, Ph, 4-bromophenyl, etc.; R¹R² = -CH=CH-CH=CH-; R³ = Me, Et, i-Pr, etc.; R⁴ = Et, Ph, pyridin-3-yl, etc.) with high efficiency. This transformation features the direct and efficient formation of a C=N bond with a high functional group tolerance under metal-free conditions. The spectroscopic properties potentially enable these sulfonyl iminopyridine compounds I to be useful new emitting materials.

Related Products of 2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., 2905-24-0.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. HPLC of Formula: 2905-24-0.

Luo, Jinyun;Lin, Muze;Wu, Leifang;Cai, Zhihua;He, Lin;Du, Guangfen research published 《 The organocatalytic synthesis of perfluorophenylsulfides via the thiolation of trimethyl(perfluorophenyl)silanes and thiosulfonates》, the research content is summarized as follows. The organic superbase t-Bu-P₄-catalyzed direct thiolation of trimethyl(perfluorophenyl)silanes and thiosulfonates was developed. Yields of perfluorophenylsulfides of up to 97% under catalysis of 5 mol% t-Bu-P₄ were achieved. This method was shown to provide an efficient way to construct the perfluorophenyl-sulfur bond under mild metal-free reaction conditions.

HPLC of Formula: 2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., 2905-24-0.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics