Category: 2905-54-6

Padmanabhan, Seetharamaiyer; Lavin, Ruth C.; Thakker, Paresh M.; Guo, Jinqing; Zhang, Lu; Moore, Deke; Perlman, Michael E.; Kirk, Cassandra; Daly, Deborah; Burke-Howie, Kathy J.; Wolcott, Teresa; Chari, Suchitra; Berlove, David; Fischer, James B.; Holt, William F.; Durant, Graham J.; McBurney, Robert N. published the artcile< Solution-Phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers>, HPLC of Formula: 2905-54-6, the main research area is acylguanidine synthesis sodium channel blocker human cardiac.

Solution-phase synthesis of various acylguanidine derivatives and the evaluation of a small library of compounds as potential sodium channel blockers are described.

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 2905-54-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6Cl2O2, HPLC of Formula: 2905-54-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Pei; Yin, Juan; Xu, Weiming; Wu, Jian; He, Ming; Hu, Deyu; Yang, Song; Song, Baoan published the artcile< Synthesis, Antibacterial Activities, and 3D-QSAR of Sulfone Derivatives Containing 1, 3, 4-Oxadiazole Moiety>, Computed Properties of 2905-54-6, the main research area is oxadiazole sulfone preparation antibacterial activity QSAR; 3D-QSAR; CoMFA; CoMSIA; antibacterial activities; sulfone derivatives; synthesis.

A series of sulfone derivatives containing 1, 3, 4-oxadiazole moiety were prepared and evaluated for their antibacterial activities by the turbidimeter test. Most compounds inhibited growth of Ralstonia solanacearum (R. solanacearum) from tomato and tobacco bacterial wilt with high potency, among which compounds I [X = H, F] exhibited the most potent inhibition against R. solanacearum from tomato and tobacco bacterial wilts with EC50 values of 19.77 and 8.29 μg/mL, resp. Our results also demonstrated that I [X = H, F] and a number of other compounds were more potent than com. bactericides Kocide 3000 and Thiodiazole Copper, which inhibited R. solanacearum from tomato bacterial wilt with EC50 values of 93.59 and 99.80 μg/mL and tobacco bacterial wilt with EC50 values of 45.91 and 216.70 μg/mL, resp. The structure-activity relationship (SAR) of compounds was studied using three-dimensional quant. structure-activity relationship (3D-QSAR) models created by comparative mol. field anal. (CoMFA) and comparative mol. similarity index anal. (CoMSIA) based on compound bioactivities against tomato and tobacco bacterial wilts. The 3D-QSAR models effectively predicted the correlation between inhibitory activity and steric-electrostatic properties of compounds

Chemical Biology & Drug Design published new progress about Agrochemicals. 2905-54-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6Cl2O2, Computed Properties of 2905-54-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Verma, Krishan K.; Singh, Umesh K.; Jain, Jainendra published the artcile< Screening of Some Novel 4, 5 Disubstituted 1, 2, 4-Triazole-3-thiones for Anticonvulsant Activity>, Name: Methyl 2,3-dichlorobenzoate, the main research area is triazole thione anticonvulsant drug screening; GABA-AT; MES; Triazol-3-thiones; anticonvulsant activity; docking; scPTZ..

In the present study, we synthesized fifteen 4, 5-disubstituted 1, 2, 4-triazol- 3-thione derivatives and evaluated for anticonvulsant activity with neurotoxicity determination The synthesized compounds were characterized using FTIR, 1H-NMR and MS. The mol. docking study was also performed to study the interactions of compounds with LYS329 residue of gamma amino butyric acid aminotransferase (GABA-AT) using Autodock 4.2 software. The anticonvulsant activity was assessed by maximal electroshock (MES) test and s.c. pentylenetetrazol (scPTZ) tests. The neurotoxicity was assessed by rotarod ataxia test. In MES test, compounds 5a, 8a and 9a were found active at 100 mg/kg and five compounds were found active at 300 mg/kg dose after 1 h of administration. After 4 h of drug administration, only two compounds 8a and 9a exhibited protection at 100 mg/kg. In scPTZ test, three compounds 2a, 6a and 8a were found active at 100 mg/kg and 7a was active at 300 mg/kg after 1 h of test drug administration. Most of the compounds were found active in MES test with 8a and 9a being the most active among all. In docking study, 2a was found to be best compound based on the binding energy of -6.5 kcal/mol and estimated inhibition constant of 17.2μM. Majority of synthesized compounds were found active in MES test, whereas only few were found to possess anti scPTZ activity. Among all compounds, only 14a caused motor coordination impairment in rotarod ataxia test at 300 mg/kg 1 h duration.

Central Nervous System Agents in Medicinal Chemistry published new progress about Anticonvulsants. 2905-54-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6Cl2O2, Name: Methyl 2,3-dichlorobenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Carroll, William A.; Kalvin, Douglas M.; Perez Medrano, Arturo; Florjancic, Alan S.; Wang, Ying; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Grayson, George; Honore, Prisca; Jarvis, Michael F. published the artcile< Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists>, Formula: C8H6Cl2O2, the main research area is purinoceptor antagonist analgesic triazole preparation SAR.

Structure-activity relationship (SAR) studies were conducted around early tetrazole-based leads 3 and 4. Replacements for the tetrazole core were investigated and the pendant benzyl substitution was reoptimized with a triazole isostere. Triazole-based P2X7 antagonists were identified with similar potency to the lead compound 4 but with improved physiochem. properties. Compound 12 (I) was active in a rat model of neuropathic pain.

Bioorganic & Medicinal Chemistry Letters published new progress about Analgesics. 2905-54-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6Cl2O2, Formula: C8H6Cl2O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Boechat, Nubia; Santos da Costa, Jorge Carlos; de Souza Mendonca, Jorge; Mello de Oliveira, Pedro Santos; Nora De Souza, Marcus Vinicius published the artcile< A simple reduction of methyl aromatic esters to alcohols using sodium borohydride-methanol system>, COA of Formula: C8H6Cl2O2, the main research area is benzyl alc preparation aromatic ester reduction sodium borohydride methanol.

Several aromatic esters were reduced to the corresponding benzyl alc. by using a sodium borohydride-methanol system. The reduction was completed within 2.0-4.0 h after refluxing in THF. The alc. products were isolated after aqueous workup in good yields (88-97%).

Tetrahedron Letters published new progress about Aralkyl alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 2905-54-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6Cl2O2, COA of Formula: C8H6Cl2O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics