Category: 29242-84-0

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 29242-84-0, name is 2-Chloro-4-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H8ClNO

To 80 mmol of compound 12 we added in succession 40 mL of water and 20 mL of conc. HCl. The suspension that formed was cooled on an ice bath, after which a solution of 85 mmol of NaNO2 in 40 mL of water was added to it under stirring over the course of 1 h. The solution was stirred for 15 min, and urea was then added until nitrogen no longer evolved. The resulting diazonium salt solution was added in small portions to a stirred solution of 120 mmol of KI in 40 mL of water at 0-5.To bring the reaction to completion, the mixture was heated at 60 for 10 min, cooled, 20% NaOH was then added, and the product was extracted with dichloromethane (3×50 mL). The organic layer was successively washed with 5% NaHSO3 (50 mL) and water (50 mL), dried over MgSO4, and distilled in a vacuum. Yield 45%, mp 136-138 (20 mmHg). 1NMR spectrum, delta, ppm: 3.80 s (3H, OCH3), 6.59 d.d(1H, J = 8.8, 2.9 Hz), 7.04 d (1H, J = 2.9 Hz), 7.68 d(1H, J = 8.8 Hz).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 29242-84-0.

Reference:
Article; Khaibulova, T. Sh.; Boyarskaya; Polukeev; Boyarskii; Russian Journal of General Chemistry; vol. 86; 10; (2016); p. 2318 – 2324; Zh. Obshch. Khim.; vol. 86; 10; (2016); p. 1670 – 1677,8;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 29242-84-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 29242-84-0, name is 2-Chloro-4-methoxyaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 4 N2-(2-chloro-4-methoxyphenyl)-N4,N4-dipropyl-5,7-dihydrofura[3,4-d]pyrimidine-2,4-diamine: [Show Image] A mixture of the compound prepared in Example 3 (300 mg) and 2-chloro-4-methoxyaniline (554 mg) was reacted for 60 minutes by microwave (90 watt, 120C). The reaction mixture was cooled to room temperature, and poured into a mixed solution of ethyl acetate / a saturated aqueous solution sodium bicarbonate and then the mixture was extracted by ethyl acetate. The extract was washed with water and a saturated aqueous solution of sodium chloride, dried over magnesium sulfate and concentrated under reduced pressure. The obtained residue was purified by column chromatography on silica gel (toluene : ethyl acetate = 20 :1 ? hexane : ethyl acetate = 8 : 1 ? 6 : 1) to give the title compound (385 mg) as a pale yellow powder having the following physical data. TLC: Rf 0.29 (hexane : ethyl acetate = 4 : 1); 1H-NMR (300MHz, CDCl3): delta 0.93, 1.59, 3.30, 3.79, 4.82, 5.18, 6.81, 6.94, 7.03, 8.28.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-4-methoxyaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; EP1666468; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 29242-84-0, These common heterocyclic compound, 29242-84-0, name is 2-Chloro-4-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Part H. A solution of the aniline from Part G (7.98 g, 50 mmol) in conc. HCl (25 mL) was cooled to -5 C., and treated dropwise with a concentrated aqueous solution of sodium nitrite (3.80 g, 55.1 mmol). After 30 minutes, the mixture was charged with 15 mL cyclohexane and 15 mL dichloromethane, then treated dropwise with a concentrated aqueous solution of potassium iodide (16.6 g, 100 mmol). This mixture was allowed to stir for 4 hours, then was extracted with dichloromethane (2*100 mL). The extracts were washed in sequence with 1 N aqueous sodium bisulfite (100 mL) and brine (60 mL), then combined, dried over magnesium sulfate, filtered and evaporated to afford sufficiently pure product, 3-chloro-4-iodoanisole (7.00 g, 26.1 mmol, 52%). TLC RF 0.39 (5:95 ethyl acetate-hexane). 1 H NMR (300 MHz, CDCl3): d 7.69 (1H, d, J=8.8 Hz), 7.03 (1H, d, J=3.0 Hz), 6.57 (1H, dd, J=8.8, 3.0 Hz), 3.78 (3H, s). MS(H2 O-GC/MS): m/e 269 (100).

Statistics shows that 2-Chloro-4-methoxyaniline is playing an increasingly important role. we look forward to future research findings about 29242-84-0.

Reference:
Patent; Dupont Pharmaceuticals Company; US6143743; (2000); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics