Category: 29882-07-3

Reference of 29882-07-3, These common heterocyclic compound, 29882-07-3, name is 4-Chloro-1,1-dimethoxybutane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2. 2-(5-Cyanomethyl-1H-indol-3-yl)ethylamine. Hydrochloride 4-Chlorobutanal dimethylacetal (37.07 g, 0.24 mol) was added to a stirred solution of 4-hydrazinobenzyl cyanide hydrochloride (47.0 g, 0.26 mol) in EtOH/H2 O (5:1; 21) and refluxed for 4.5 h. The reaction mixture was evaporated to dryness under vacuum, MeOH (150 ml) added, and the mixture left at 0° C. for 10 h. The resultant pale yellow precipitate was filtered under vacuum, washed with Et2 O/MeOH (5:1; 2*100 ml) and dried. The product was used without further purification (24.1 g, 40percent), m.p. 239°-241° C.; Rf 0.4 in CH2 Cl2 /EtOH/NH3 (40:8:1); 1 H NMR (360 MHz, D2 O) 3.18 (2H, t, J=7.1 Hz, CH2); 3.36 (2H, t, J=7.1 Hz, CH2); 4.02 (2H, s, CH2); 7.22 (1H, dd, J=1.5and 8.4 Hz, Ar-H); 7.36 (1H, s, Ar-H); 7.56 (1H, d, J=8.4 Hz, Ar-H); 7.66 (1H, s, Ar-H).

Statistics shows that 4-Chloro-1,1-dimethoxybutane is playing an increasingly important role. we look forward to future research findings about 29882-07-3.

Reference:
Patent; Merck Sharp & Dohme Limited; US5298520; (1994); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

29882-07-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 29882-07-3, name is 4-Chloro-1,1-dimethoxybutane belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1. N-(1-Benzylpiperidin-4-yl)-N-[2-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)ethyl]amine Hydrogen Oxalate 4-(1,2,4-Triazol-4-yl)phenylhydrazine (3 g, 17.12 mmol) and 4-chlorobutyraldehyde dimethyl acetal (2.35 g, 15.41 mmol) were heated at reflux in ethanol/water (5:1, 120 ml) in the presence of concentrated hydrochloric acid (3.77 ml) under nitrogen for 6 hours. The volatiles were evaporated and the residue partitioned between 2M sodium hydroxide (50 ml) and n-butanol. The organic layer was separated and the solvent evaporated. The crude product was purified by column chromatography on silica using dichloromethane/methanol/ammonia (40:8:1) to give 2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethylamine as a brown oil (1.9 g, 49percent).

The synthetic route of 4-Chloro-1,1-dimethoxybutane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck Sharp & Dohme Ltd.; US6140347; (2000); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics