Category: 30273-47-3

Application of 30273-47-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 30273-47-3, name is 4-Bromo-5-chloro-2-methylaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Under ice-bath cooling, acetic anhydride (1.553 mL, 16.46 mmol), was added to a solution of 4-bromo-5-chloro-2-methylaniline (1.815 g, 8.23 mmol) in chloroform (20 mL), Potassium acetate (0.889 g, 9.05 mmol), a solution of 18-crown-6 (0.435 g, 1 ,646 mmol) in chloroform (5 mL) and then t-butyl nitrite (2.282 mL, 17.29 mmol) were then added sequentially and the mixture was refluxed at 78C for 16 h. The reaction mixture was cooled and stirred (under ice bath cooling) with saturated aqueous sodium bicarbonate solution (20 mL). The aqueous layer was separated and extracted with DCM (3 x 20 mL) and the organics combined and reduced. The resulting residue was purified twice by chromatography on silica gel, eluting with a gradient of 0-20% ethyl acetate in isohexane to afford the title compound as an orange solid (1.52 g). H NMR (CDCI3, 400MHz) delta ppm: 2.79 (3H, s), 8.03 (1 H, s), 8.06 (1 H, d, J 1 Hz), 8.64 (1 H, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-5-chloro-2-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; BAILEY, James; KING, Nigel Paul; LIN, Xichen; REN, Feng; TAN, Kheng-Chuan; MAK, Sing Yeung; WO2011/72488; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 30273-47-3,Some common heterocyclic compound, 30273-47-3, name is 4-Bromo-5-chloro-2-methylaniline, molecular formula is C7H7BrClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 95 Preparation of 4-bromo-2,3-dichloro-6-methylaniline This material was prepared from 4-bromo-5-chloro-2-methylaniline by chlorination with N-chlorosuccinimide. The product was isolated as a solid, m.p. 66-68 C. The product was characterized by IR and 1 H NMR spectroscopy and combustion analysis.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-5-chloro-2-methylaniline, its application will become more common.

Reference:
Patent; The Dow Chemical Company; US4818273; (1989); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 30273-47-3 as follows. Product Details of 30273-47-3

First, into a 500-mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed dichloromethane (400 mL), 4-bromo-5-chloro-2-methylaniline (25 g, 113.38 mmol, 1.00 equiv). This was followed by the addition of TFAA (trifluoroacetic anhydride, 27.4 g, 130.46 mmol, 1.15 equiv) dropwise with stirring at 0 C. in a water/ice bath. The resulting solution was allowed to react, with stirring, for an additional 1 h at room temperature. The resulting mixture was concentrated under vacuum. This resulted in 30 g (84%) of N-(4-bromo-5-chloro-2-methylphenyl)-2,2,2-trifluoroacetamide as a white solid. First, a solution of 4-bromo-5-chloro-2-methylaniline (5 g, 22.68 mmol, 1.00 equiv), TFAA (5.5 g, 26.19 mmol, 1.50 equiv) in dichloromethane (50 mL) was placed into a 100-mL round-bottom flask. The resulting solution was stirred for 4 h at room temperature. The resulting mixture was concentrated under vacuum. This resulted in 7.9 g (crude) of N-(4-bromo-5-chloro-2-methylphenyl)-2,2,2-trifluoroacetamide as a brown solid.

According to the analysis of related databases, 30273-47-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERIAL, INC.; Meng, Charles; Le Hir de Fallois, Loic; (40 pag.)US2015/366198; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 30273-47-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 30273-47-3, name is 4-Bromo-5-chloro-2-methylaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 79 – Preparation of 4-bromo-2,3-dichloro-6-methyl aniline This material was prepared from 4-bromo-5-chloro-2-methyl aniline by chlorination with N-chlorosuccinimide. The product was isolated as a solid, mp 66-68C. The product was characterized by IR and 1H NMR spectroscopy and combustion analysis.

The synthetic route of 4-Bromo-5-chloro-2-methylaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE DOW CHEMICAL COMPANY; EP142152; (1991); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 30273-47-3, name is 4-Bromo-5-chloro-2-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H7BrClN

Example 11; 3-(4-(5-(8-Bromo-6-(trifluor omethv l)im idazo [ 1 ,2-alpha] pyridin-2-yl)- 1 ,2,4-oxadiazol-3-yl)-2- chloro-5-methylphenyl)propanoic acid; 2-Methyl-4-bromo-5-chloro benzonitrile (57).; To a stirred solution of 2-methyl-4- bromo-5-chloro aniline (56) (2.9 g, 13 mmol) in concentrated HCl (14.5 rnL) cooled to 0 0C was added a solution of sodium nitrite (1 g, 14 mmol) in water (3.5 mL) slowly over 20 min. After stirring at 0 0C for 35 min, a pre-cooled solution of copper (I) cyanide (11.80 g, 13.1 mmol) and sodium cyanide (6.46 g, 13.1 mmol) in water (81 mL) was gradually added to the above solution of diazonium salt at 0 0C over a period of 50 min. After addition, the resulting mixture was stirred at room temperature for 18 h. The precipitated solid was filtered, washed with water and dried. The resulting solid was then dissolved in EtOAc and washed with water followed by saturated NaCl solution. The organic phase was dried over Na2SO4 and concentrated in vacuo. The crude compound was purified by column chromatography, eluting with 5-10% EtOAc/hexane, to afford the title intermediate 57 as a white solid (2.1 g, yield 69%).

The synthetic route of 4-Bromo-5-chloro-2-methylaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EXELIXIS, INC.; CANNE BANNEN, Lynne; CHAN, Diva Sze-ming; GU, Xiao-hui; MAC, Morrison, B.; NG, Stephanie; WANG, Tie-lin; WANG, Yong; XU, Wei; WO2010/65760; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics