Category: 3032-32-4

Lee, Jun Young published the artcileDesign, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments, Recommanded Product: 2-Amino-3,6-dichlorobenzoic acid, the main research area is arylaminoquinazolinone preparation anticoronaviral activity; structure arylaminoquinazolinone inhibition SARS CoV2 MERS; pharmacokinetics metabolism toxicity hERG cytochrome inhibition dichlorophenylaminoquinazolinone; 2-aminoquinazolinone; Antiviral; Coronavirus; MERS-CoV; SARS-CoV-2.

Despite the rising threat of fatal coronaviruses, there are no general proven effective antivirals to treat them. 2-Aminoquinazolin-4(3H)-one derivatives were newly designed, synthesized, and investigated to show the inhibitory effects on SARS-CoV-2 and MERS-CoV. Among the synthesized derivatives, 7-chloro-2-((3,5-dichlorophenyl)amino)quinazolin-4(3H)-one I (R = Cl; R1 = H) and 2-((3,5-dichlorophenyl)amino)-5-hydroxyquinazolin-4(3H)-one I (R = H; R1 = HO) showed the most potent anti-SARS-CoV-2 activities (IC50 < 0.25μM) and anti-MERS-CoV activities (IC50 < 1.1μM) with no cytotoxicity (CC50 > 25μM). In addition, both compounds showed acceptable results in metabolic stabilities, hERG binding affinities, CYP inhibitions, and preliminary PK studies.

Bioorganic & Medicinal Chemistry Letters published new progress about Anticoronaviral agents. 3032-32-4 belongs to class chlorides-buliding-blocks, name is 2-Amino-3,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, Recommanded Product: 2-Amino-3,6-dichlorobenzoic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

James, C. S. published the artcilePlant growth-regulating substances. XXVI. Isatic and anthranilic acids, Formula: C7H5Cl2NO2, the main research area is isatic acid growth regulation; anthranilic acid growth regulation; growth regulation anthranilic acid.

The plant growth-regulating activities of isatic acid and 26 isatic acid derivatives, together with the 27 corresponding anthranilic acids, were assessed in the wheat cylinder, the pea segment, and pea curvature tests. Activity was sustained by substitution in the 4-and 5-positions of isatic acid as in Na 4-chloroisatate and Na 5-bromoisatate but decreased by substitution in the 3- and 6-positions as in Na 3-chloroisatate and Na 6-chloroisatate. In the anthranilic acid series, the parent acid was inactive but the introduction of a large grouping (Br or I) into the 5-position as in Na 5-iodoanthranilate conferred activity. The 3,6- and 5,6-dichloro and the 3,6-dibromo acids such as Na 3,6-dichloroisatate were also active; compounds substituted in the 4-position to the carboxyl group or disubstituted in the 3 and 5 positions as in Na 3,5-dichloroisatate, were, as expected, inactive. Wheat coleoptile and pea stem segments metabolized Na isatate and Na 5-chloroisatate to the corresponding Na anthranilate and Na 5-chloroanthranilate, together with an unidentified nonacidic metabolite in each case. The acids apparently possess activity per se since there was no evidence that the growth regulating activity of isatic acids was related to this breakdown. 19 references.

Annals of Applied Biology published new progress about Hormones, plant Role: BIOL (Biological Study). 3032-32-4 belongs to class chlorides-buliding-blocks, name is 2-Amino-3,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, Formula: C7H5Cl2NO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Ya published the artcileRemote γ-C(sp3)-H Alkylation of Aliphatic Carboxamides via an Unexpected Regiodetermining Pd Migration Process: Reaction Development and Mechanistic Study, Category: chlorides-buliding-blocks, the main research area is remote alkylation aliphatic carboxamide strained bicyclic alkene palladium catalyst.

In the presence of accessible β-C-H bonds, γ-C-H activation of saturated aliphatic carboxamides remains unresolved because β-C-H activation is kinetically favored. This is almost a dogma in the development of C-H activation reactions. Here we report a strategy to change this dogma, as we have found that a Pd-catalyzed, ligand-enabled remote γ-alkylation of saturated aliphatic carboxamides can be realized in the presence of more accessible β-C-H bonds by using strained bicyclic alkenes as the coupling partners. D. functional theory calculations and experiments suggested that the realization of the present reaction is due to a change in the regiodetermining step from commonly encountered irreversible C-H activations, which are reversible here, to an unexpected Pd migration process, which is regiodetermining. This is a new strategy to achieve γ-C-H activation, compared with the previous strategy, making γ-C-H activation both the turnover- and regiodetermining step.

ACS Catalysis published new progress about Alkylation catalysts, regioselective. 3032-32-4 belongs to class chlorides-buliding-blocks, name is 2-Amino-3,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yamamoto, Gaku published the artcileRestricted rotation involving the tetrahedral carbon. XLV. Appearance of a maximum in the rotational barriers of 9-(1,1-dimethyl-2-phenylethyl)triptycenes at a medium-sized peri-substituent, Formula: C7H5Cl2NO2, the main research area is kinetics rotational isomerization phenethyltriptycene; equilibrium rotational isomerization phenethyltriptycene; atropisomerism substituent effect phenethyltriptycene; rotational barrier substituent effect phenethyltriptycene; potential barrier substituent effect phenethyltriptycene; proton NMR phenethyltriptycene.

The rotational isomers of seven I (R = H, F, OMe, Cl, Br, CF3, Me; R1 = H, Cl; R2 = H, OMe, Cl, Me) were stereoselectively prepared and their rotational isomerization kinetics were determined; compounds with relatively small R and R2 (F and OMe) had larger barriers than I (R = R2 = H, R2 = Cl) and I (R, R2 = Cl, Br, Me, CF3) had lower barriers even though R and R2 were relatively large. This anomaly is due to large mol. deformations. The equilibrium constants for the atropisomerism and the 1H NMR are discussed.

Bulletin of the Chemical Society of Japan published new progress about Conformational transition enthalpy. 3032-32-4 belongs to class chlorides-buliding-blocks, name is 2-Amino-3,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, Formula: C7H5Cl2NO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Szupiluk, Artur published the artcileSynthesis of sterically crowded 9-nitrotriptycenes by the Diels-Alder cycloaddition reaction, SDS of cas: 3032-32-4, the main research area is nitroanthracene halobenzyne regioselective Diels Alder reaction; nitrotriptycene preparation.

The synthesis of novel sterically crowded triptycenes as attractive components for the construction of models for various mol. dynamic studies was reported. 9-Nitrotriptycenes were obtained by the Diels-Alder reactions between 9-nitroanthracene and tetrabromobenzyne as well as 1,4-dichloro-9-nitroanthracene and 2,6-dichlorobenzyne. Interesting regioselectivity relative to the central and terminal rings was observed Moreover, 1,2,3,4-tetrabromo-9-nitrotriptycene was further functionalized to afford 1,2,3,4-tetrabromotriptycyl-9-ammonium tetrafluoroborate in two-steps. The impact of steric hindrance on the geometry of the mol. was estimated on the basis of single crystal X-ray diffraction data.

Tetrahedron Letters published new progress about Diels-Alder reaction, regioselective. 3032-32-4 belongs to class chlorides-buliding-blocks, name is 2-Amino-3,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, SDS of cas: 3032-32-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chang, Ning-hui published the artcileSynthesis of Substituted Picenes through Pd-Catalyzed Cross-Coupling Reaction/Annulation Sequences and Their Physicochemical Properties, Application In Synthesis of 3032-32-4, the main research area is picene chemoselective preparation; palladium catalyzed Suzuki Miyaura coupling cyclocondensation chloroiodobenzene aralkenylboronate; methoxypicene preparation mol crystal structure.

Picenes I (R = H, Et; R1 = H, MeO; R2 = H, Me3Si; R3 = H, MeO; R4 = H, MeO) were prepared from 1,4-dichloro-2,3-diiodobenzene and alkenyl pinacolboronates II (R = H, Et; R1 = H, MeO; R2 = H, Me3Si; R3 = H, MeO; R4 = H, MeO; BPin = 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) by palladium-catalyzed Suzuki-Miyaura coupling to give 2,3-bis(arylalkenyl)-1,4-dichlorobenzenes III (R = H, Et; R1 = H, MeO; R2 = H, Me3Si; R3 = H, MeO; R4 = H, MeO) in 38-68% yields followed by palladium-catalyzed cyclization and C-H activation to give I in 23-60% yields. The UV/visible absorption and fluorescence spectra, HOMO and LUMO energies and orbital structures, and oxidation potentials for I were determined; I were p-type semiconductors and were stable to cyclic voltammetry. The structure of I (R = R1 = R2 = R3 = H; R4 = MeO) was determined by X-ray crystallog.

Organic Letters published new progress about C-H bond activation. 3032-32-4 belongs to class chlorides-buliding-blocks, name is 2-Amino-3,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, Application In Synthesis of 3032-32-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics