Category: 309721-44-6

Adding a certain compound to certain chemical reactions, such as: 309721-44-6, name is 2-Bromo-1-chloro-3-fluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 309721-44-6, COA of Formula: C6H3BrClF

A mixture of 146.1 g (1.36 mol) of p-toluidine, 12.6 g (0.02 mol) of (+-)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl, 261.9 g (2.73 mol) of sodium t-butoxide, 314.1 g (1.50 mol) of 2-bromo-3-fluoro-chlorobenzene and 6.3 g (0.0069 mol) of tris(dibenzylideneacetone)dipalladium(0) in 3000 ml of toluene is heated to 110 over 30 minutes and stirred an additional 4 hours at this temperature. The mixture is cooled to room temperature and a solution of 680 ml 37% hydrochloric acid and 680 ml of water is added over 15 minutes. The mixture is stirred for 20 minutes and filtered through a pad of Celite. The layers are separated and the organic phase is washed twice with 680 ml of water and once with a solution of 225 g of sodium chloride in 680 ml of water. The solvents are evaporated under reduced pressure to give N-(2′-chloro-6′-fluorophenyl)-4-methylaniline as an oil, b.p. 129-131/0.5 mm Hg.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-chloro-3-fluorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Novartis AG; US6291523; (2001); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 309721-44-6, The chemical industry reduces the impact on the environment during synthesis 309721-44-6, name is 2-Bromo-1-chloro-3-fluorobenzene, I believe this compound will play a more active role in future production and life.

General procedure: A 250 mLround-bottom flask was charged with 1-bromo-4-chloro-2-fluoro-benzene (8.5 mL,68.0 mmol), hydrazine monohydrate (13 mL, 270 mmol) and dimethylsulfoxide (25mL) and the solution was stirred at 70 C for 3 days. The reaction was thencooled to room temperature and water (200 mL) was added. The precipitate was collected by filtration and dried under vacuum for 16 hours

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-chloro-3-fluorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Rene, Olivier; Fauber, Benjamin P.; Tetrahedron Letters; vol. 55; 4; (2014); p. 830 – 833;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 309721-44-6, name is 2-Bromo-1-chloro-3-fluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 309721-44-6, Quality Control of 2-Bromo-1-chloro-3-fluorobenzene

General procedure: To a mixture of intermediate C-3 (1 eq), halo-(hetero)arene BB-16 (1.1 to 2 eq) and sodium ferf-butoxide (2 to 2.3 eq) in toluene (3 to 7.8 mL/mmol) under N2, was added BINAP (0.2 to 0.3 eq) and Pd2(dba)3 (0.1 to 0.15 eq). The rxn mixture was flushed with N2, heated under stirring at a given temperature for a given time (see Table ). It was partitioned between water and EtOAc or DCM and the org. phase was washed with brine, dried over MgS04 and concentrated in vacuo. The crude was purified by CC using Hept/EtOAc or DCM/MeOH. When necessary, an additional purification by prep. LC-MS using methods 1, 3, 4, 5, 6 or 10 was performed.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-1-chloro-3-fluorobenzene, and friends who are interested can also refer to it.

Reference:
Patent; IDORSIA PHARMACEUTICALS LTD; FROIDEVAUX, Sylvie; HUBLER, Francis; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon; (266 pag.)WO2019/137927; (2019); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 309721-44-6, name is 2-Bromo-1-chloro-3-fluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 309721-44-6, Recommanded Product: 309721-44-6

40.0 g (1.0 eq) of Compound 1 (5,12-dihydroindolo [3,2-a] carbazole) and 26.27 g (1.5 eq) of Potassium tert-butoxide (KOtBu) were dissolved in dimethylformamide (DMF)And the mixture was heated and stirred.At the start of the reflux, 40.0 g (1.1 eq) of compound 1a (2-bromo-1-chloro-3-fluorobenzene) was added.After the reaction was completed after 3 hours, the reaction was poured into water and the crystals were dropped and filtered.The filtered solid was completely dissolved in chloroform (CHCl3), washed with water, and again reduced in pressure to remove the solvent. The residue was purified by column chromatography to obtain 49.5 g of Compound A-1 (yield: 71%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; LG Chem, Ltd.; Lee Jeong-ha; Park Tae-yun; (125 pag.)KR2017/126814; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 309721-44-6, name is 2-Bromo-1-chloro-3-fluorobenzene, molecular formula is C6H3BrClF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H3BrClF

To a mixture of sodium tert-butoxide (138 mg, 1 .4 mmo) in THF (1.0 mL) was added I ,1 ,1 -trifiuoro-2-propano (0.14 mL, 1.5 mmo) and 2-bromo-1-choro-3-fluorobenzene (200 mg, 0.96 mmofl n DMF (2.0 rnL). The reacfion mxture was heated at 80 C for 24 h. After coohng to rt, EtOAc (5.0 mL) was added to the reacton rnxture and washed sequentaHy with 1 M HC (2.5 mL), saturated aqueous NaHCO3, and brine. The aqueous ayers were extractedw[th EEtOAc, and the combined organic extracts were dred (Na2SO4), ifitered and concentrated. Purflcaton by FCC (0 -10% EtOAc I hexanes) afforded the tWe compound as an o (87 rng, 30% yed). ?H NMR (400 MHz, CDC3) oe 7.23 (rn, 2H), 6.86 (dd, J = 7.3, 2.4 Hz, I H), 4.72 4.58 (m, 1 H), 1.62 – 1.49 (m, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 309721-44-6, its application will become more common.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; RAVULA, Suchitra; SWANSON, Devin M.; SAVALL, Bradley M.; AMERIKS, Michael K.; (250 pag.)WO2016/176449; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 309721-44-6, name is 2-Bromo-1-chloro-3-fluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 309721-44-6, Quality Control of 2-Bromo-1-chloro-3-fluorobenzene

To a solution of 2-bromo-l-chloro-3-fluorobenzene (6.0 g, 29 mmol) in tetrahydrofuran (30 mL) at -70 C was added dropwise lithium diisopropylamide (2 M in tetrahydrofuran/n-heptane, 22 mL, 43 mmol). The resulting solution was stirred at -70 C for 0.5 hour. Then N, N – dimethylformamide (4.2 g, 57 mmol) was added slowly, and stirring was continued at -70 C for another 0.5 hour. On completion of the reaction by TLC [petroleum ether: ethyl acetate = 10: 1, Rf=0.6], the reaction was quenched with saturated aqueous ammonium chloride (2 mL) at 0 C and extracted with acetate ethyl (3 chi 20 mL). The combined organic extracts were concentrated to give compound A-49 (4.0 g, 58% yield) as a yellow solid. -NMR (CD3OD, 400 MHz): delta 7.64-7.57 (m, 1H), 7.21-7.17 (m, 1H), 6.02 (s, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; FORUM PHARMACEUTICALS, INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; MCRINER, Andrew, J.; (127 pag.)WO2016/201096; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics