Category: 320-60-5

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 320-60-5, name is 2,4-Dichloro-1-(trifluoromethyl)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2,4-Dichloro-1-(trifluoromethyl)benzene

To a cooled [(0C)] suspension of aluminium trichloride (2.02 g, 15 mmol, 3.0 eq. ) in 1,2- dichloroethane (7 mL) was slowly added 2, 4-dichlorobenzotrifluoride (1.1 g, 5 mmol) followed by [FLUOROBENZENE] (0.483 g, 5 mmol, 1.0 eq. ). The reaction mixture was stirred at [0-5C] for 5h, then poured onto ice and extracted with dichloromethane. The combined organic layer was washed with brine, dried over sodium sulfate and filtered. The volatiles were removed in vacuo, affording the title compound (1.63 g, quant. ) as yellow oil.

The synthetic route of 320-60-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F.Hoffmann-la Roche AG; WO2004/13120; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 320-60-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 320-60-5, name is 2,4-Dichloro-1-(trifluoromethyl)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

65 ml of 1.60 mol/1 of n-butyl lithium was slowly dropwise added at a temperature of from-75 to-65C over a period of 30 minutes to a solution of 14.8 ml of 2,4- dichlorobenzotrifluoride in 350 ml of anhydrous tetrahydrofuran, followed by stirring at-70C for 1 hour. At a temperature of from-75 to-65C, 15.9 ml of trimethyl borate was gradually dropwise added, followed by stirring for a while. Then, an ice bath was removed, and the mixture was stirred for 1 hour while gradually warming it to room temperature. Then, the reaction system was cooled to 0C, and 70 ml of ice water and 80 ml of 2N hydrochloric acid were gradually added with stirring, followed by stirring at room temperature overnight. Extraction with diethyl ether was carried out (300 ml x twice). The organic layers were put together, washed with a saturated sodium chloride aqueous solution and then dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. Suction drying was thoroughly carried. out to obtain 28 g of crude 2,6-dichloro-3-trifluoromethylbenzene boronic acid. This product was used as raw material for the next coupling reaction.

The synthetic route of 2,4-Dichloro-1-(trifluoromethyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ISHIHARA SANGYO KAISHA, LTD.?; WO2005/44007; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 320-60-5, name is 2,4-Dichloro-1-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., SDS of cas: 320-60-5

Example 3; R-(+)-[2-(2,4-Dichloro-phenyl)-2-(4-fluoro-phenyl)-6-fluoro-benzo[1,3]dioxol-5-yl]-morpholin-4-yl-methanone; Preparation of 2,4-dichloro-4′-fluoro-diphenyldichloromethane; To a cooled (0 C.) suspension of aluminium trichloride (2.02 g, 15 mmol, 3.0 eq.) in 1,2-dichloroethane (7 mL) was slowly added 2,4-dichlorobenzotrifluoride (1.1 g, 5 mmol) followed by fluorobenzene (0.483 g, 5 mmol, 1.0 eq.). The reaction mixture was stirred at 0-5 C. for 5 h, then poured onto ice and extracted with dichloromethane. The combined organic layer was washed with brine, dried over sodium sulfate and filtered. The volatiles were removed in vacuo, affording the title compound (1.63 g, quant.) as yellow oil. MS: m/e=325.0 ([M+H]+).

The synthetic route of 320-60-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Frei, Beat; Plancher, Jean-Marc; Roever, Stephan; Zimmerli, Daniel; US2006/293318; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics