Adding a certain compound to certain chemical reactions, such as: 32137-20-5, name is 1-Chloro-2-fluoro-4-(trifluoromethyl)benzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 32137-20-5, Computed Properties of C7H3ClF4
(b) Preparation of 3(2-chloro-5-trifluoromethylphenoxy)benzoic acid. 3-Hydroxybenzoic acid (3.45 g) was added to a solution of potassium hydroxide (2.8 g) in methanol. The solution was evaporated under reduced pressure to give a white solid. This was taken up in dry dimethylsulphoxide (25 ml). The resulting solution was stirred and heated at 170 with anhydrous potassium carbonate (1.25 g) and 4-chloro-3-fluorobenzotrifluoride (5 g) for 12 hours. The mixture was then cooled and poured into water, (500 ml). The mixture was extracted with ether and then acidified (HCl). The precipitate which formed was recrystallized from petroleum (b.p. 60-80) to give the required acid (4.5 g) with a melting point of 142-143.
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Reference:
Patent; Imperial Chemical Industries PLC; US4738711; (1988); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics