Category: 32333-53-2

Wang, Bin published the artcileBase-mediated tandem sulfonylation and oximation of alkenes in water, HPLC of Formula: 32333-53-2, the publication is Green Chemistry (2017), 19(24), 5794-5799, database is CAplus.

A base-mediated bifunctionalization of alkenes such as ethenyl-benzene, methylene-cyclopentane, 1-hexene, etc. for the synthesis of α-sulfonylethanone oximes RC(=NOH)CH(R¹)SO₂R² (R = Ph, naphthalen-2-yl, (CH₂)₃CH₃, 4-(chloromethyl)phenyl, etc.; RR¹ = -(CH₂)₃-, R¹ = H, Br; R² = 4-methoxyphenyl, thiophen-2-yl, naphthalen-2-yl, CH₃C(O), etc.) was developed in water under metal-free conditions. This reaction features a wide substrate scope and facile starting materials to afford the desired products in high yields.

Green Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C12H10FeO4, HPLC of Formula: 32333-53-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Xinyu published the artcileFluorocyclization of Allyl Alcohols and Amines to Access 3-Functionalized Oxetanes and Azetidines, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Organic Letters (2021), 23(9), 3674-3679, database is CAplus and MEDLINE.

An efficient method to prepare 3-functionalized oxetanes and azetidines I [R¹ = H, Me, Ph, etc.; R² = Me, Ph, 2-FC₆H₄, etc.; R¹R² = (CH₂)₄, (CH₂)₅, (CH₂)₂O(CH₂)₂, etc.; X = O, NC(O)Ph, NSO₂Ph, etc.] was realized by fluorocyclization of readily available 2-azidoallyl alcs. and amines. Notably, this was the first example applying the fluorocyclization strategy to construct four-membered heterocycles. The pendant electron-donating group (-N₃ or -OR) played a crucial role in polarizing the C=C double bond and facilitating the cyclization process, as verified by DFT and exptl. studies.

Organic Letters published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Wentian published the artcileDesign and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC), Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2019), 62(10), 5217-5241, database is CAplus and MEDLINE.

Despite advances in targeted anticancer therapies, there are still no small-mol.-based therapies available that specifically target colorectal cancer (CRC) development and progression, the second leading cause of cancer deaths. We previously disclosed the discovery of truncating adenomatous polyposis coli (APC)-selective inhibitor 1 (TASIN-1), a small mol. that specifically targets colorectal cancer cells lines with truncating mutations in the adenomatous polyposis coli (APC) tumor suppressor gene through inhibition of cholesterol biosynthesis. Here, we report a medicinal chem. evaluation of a collection of TASIN analogs and activity against colon cancer cell lines and an isogenic cell line pair reporting on the status of APC-dependent selectivity. A number of potent and selective analogs were identified, including compounds with good metabolic stability and pharmacokinetic properties. The compounds reported herein represent a first-in-class genotype-selective series that specifically target apc mutations present in the majority of CRC patients and serve as a translational platform toward a targeted therapy for colon cancer.

Journal of Medicinal Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C6H8O4, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sbenati, Rawan M. published the artcileDesign, synthesis, biological evaluation, and modeling studies of novel conformationally-restricted analogues of sorafenib as selective kinase-inhibitory antiproliferative agents against hepatocellular carcinoma cells, Computed Properties of 32333-53-2, the publication is European Journal of Medicinal Chemistry (2021), 113081, database is CAplus and MEDLINE.

Sorafenib is one of the clin. used anticancer agents that inhibits several kinases. In this study, novel indole-based rigid analogs of sorafenib were designed and synthesized in order to enhance kinase selectivity and hence minimize the side effects associated with its use. The target compounds possess different linkers; urea, amide, sulfonamide, or thiourea, in addition to different terminal aryl moieties attached to the linker in order to investigate their impact on biol. activity. They were tested against Hep3B, Huh7, and Hep-G2 hepatocellular carcinoma (HCC) cell lines to study their potency. Among all the tested target derivatives, arylaminocarbonylaminoindolylpicolinamide I exerted superior antiproliferative potency against all the three tested HCC cell lines compared to sorafenib. Based on these preliminary results, I was selected for further biol. and in silico investigations. Up to 30μM, I did not inhibit 50% of the proliferation of WI-38 normal cells, which indicated promising selectivity against HCC cells than normal cells. In addition, I exerted superior kinase selectivity than sorafenib. It is selective for VEGFR2 and VEGFR3 angiogenesis-related kinases, while sorafenib is a multikinase inhibitor. Superior kinase selectivity of I to sorafenib can be attributed to its conformationally-restricted indole nucleus and the bulky N-methylpiperazinyl moiety. Western blotting was carried out and confirmed the ability of I to inhibit VEGFR2 kinase inside Hep-G2 HCC cells in a dose-dependent pattern. I induces apoptosis and necrosis in Hep-G2 cell line, as shown by caspase-3/7 and lactate dehydrogenase (LDH) release assays, resp. Moreover, I did not inhibit hERG. Thus, we could achieve a more selective kinase inhibitor than sorafenib with retained or even better antiproliferative potency against HCC cell lines. Furthermore, mol. docking and dynamic simulation studies were carried out to investigate its binding mode with VEGFR2 kinase. The mol. has a unique orientation upon binding with the kinase.

European Journal of Medicinal Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Computed Properties of 32333-53-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nourry, Arnaud published the artcileBRAF inhibitors based on an imidazo[4,5]pyridin-2-one scaffold and a meta substituted middle ring, Application of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Journal of Medicinal Chemistry (2010), 53(5), 1964-1978, database is CAplus and MEDLINE.

We recently reported on the development of a novel series of BRAF inhibitors based on a tripartite A-B-C system characterized by a para-substituted central aromatic core connected to an imidazo[4,5]pyridin-2-one scaffold and a substituted urea linker. Here, we present a new series of BRAF inhibitors in which the central Ph ring connects to the hinge binder and substrate pocket of BRAF with a meta-substitution pattern e. g. I. The optimization of this new scaffold led to the development of low-nanomolar inhibitors that permits the use of a wider range of linkers and terminal C rings while enhancing the selectivity for the BRAF enzyme in comparison to the para series.

Journal of Medicinal Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Application of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Wen-Ming published the artcileThe synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid, Related Products of chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(10), 1943-1948, database is CAplus and MEDLINE.

A series of N-sulfonaminoethyloxime derivatives of dehydroabietic acid were synthesized and investigated for their antibacterial activity against Staphylococcus aureus Newman strain and multidrug-resistant strains (NRS-1, NRS-70, NRS-100, NRS-108 and NRS-271). Most of the target compounds having chloro, bromo, trifluoromethyl Ph moiety exhibited potent in vitro antistaphylococcal activity. The meta-CF3 Ph derivative T23 showed the highest activity with MIC of 0.390.78 μg/mL against S. aureus Newman, while several analogs showed similar potent antibacterial activity with MIC values between 0.78 and 1.56 μg/mL against fve multidrug-resistant S. aureus. The stability of T35 in plasma of SD rat and the cellular cytotoxicity were also evaluated.

Bioorganic & Medicinal Chemistry Letters published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C38H24F4O4P2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Bin published the artcileTBN-mediated regio- and stereoselective sulfonylation & oximation (oximosulfonylation) of alkynes with sulfonyl hydrazines in EtOH/H₂O, Formula: C7H3Cl2F3O2S, the publication is Green Chemistry (2019), 21(2), 205-212, database is CAplus.

Terminal aryl alkynes such as phenylacetylene underwent regioselective and diastereoselective cascade sulfonylation and oximation reactions with arylsulfonyl hydrazides such as 4-MeC₆H₄SO₂NHNH₂ mediated by tert-Bu nitrite (TBN), hydrazine hydrate, and imidazole in 40:1 EtOH:H₂O to yield (Z)-α-sulfonyl aryl Me ketoximes such as (Z)-4-MeC₆H₄SO₂CH₂C(:NOH)Ph. The mechanism was studied through identification of byproducts and radical inhibition and deuterium incorporation studies.

Green Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C4H6O3, Formula: C7H3Cl2F3O2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Guo, Zhenbo published the artcileDesign, synthesis and evaluation of novel (S)-tryptamine derivatives containing an allyl group and an aryl sulfonamide unit as anticancer agents, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Bioorganic & Medicinal Chemistry Letters (2019), 29(9), 1133-1137, database is CAplus and MEDLINE.

A series of (S)-tryptamine derivatives containing an allyl group and an aryl sulfonamide unit, I (R = Ph, 3-Cl-4-FC₆H₃, 4-Br-2-ClC₆H₄, etc.) and II [R = Ph, 2,4,6-(Me₂CH)₃C₆H₂], were designed, synthesized and evaluated for their potential application as anticancer agents. The structures of the synthesized compounds were characterized by ¹H NMR, ¹³C NMR and ESI-MS spectral analyses. The target compounds were evaluated for their in vitro cytotoxicity against HepG2, HeLa, CNE1 and A549 human cancer cell lines. Some of the synthesized compounds showed moderate to good anticancer activities against four selected cancer cell lines, among of which I [R = 2,4,6-(Me₂CH)C₆H₂] (III) was found to be the most active analog possessing IC₅₀ values 16.5-18.7 μM. Further mechanism studies revealed that compound III could significantly induce HepG2 cell cycle arrest at G1 phase, promote cell apoptosis, and inhibit the colony formation as well.

Bioorganic & Medicinal Chemistry Letters published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Ying published the artcileCharge-Transfer Complex Promoted Regiospecific C-N Bond Cleavage of Vicinal Tertiary Diamines, Recommanded Product: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Advanced Synthesis & Catalysis (2018), 360(18), 3502-3506, database is CAplus.

A catalyst-free, charge-transfer complex promoted coupling of sulfonyl chlorides RSO₂Cl (R = cyclopropyl, Ph, 3,5-F₂C₆H₃, 2-naphthyl, 2-thienyl, 8-quinolinyl, etc.) with vicinal tertiary diamines R¹R²NCH₂CH₂NR¹R² (R¹ = R² = Me, Et, n-Pr, i-Pr, i-Bu; R¹ = Me, R² = Ph, 3-MeC₆H₄, etc.; R¹R²N = 1-pyrrolidinyl, 4-morpholinyl) to generate sulfonamides RSO₂NR¹R² is presented. Mechanistic studies showed that these reactions proceed via charge transfer of vicinal tertiary diamines to sulfonyl chlorides, forming the unstable sulfonyl quaternary ammonium-like complexes which induce the regiospecific intramol. C-N bond cleavage of vicinal tertiary diamines.

Advanced Synthesis & Catalysis published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Recommanded Product: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Ying published the artcileDebenzylative Sulfonylation of Tertiary Benzylamines Promoted by Visible Light, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is European Journal of Organic Chemistry (2021), 2021(12), 1896-1900, database is CAplus.

An efficient, general, inexpensive, and environmentally friendly photosynthesis of sulfonamides via visible light promoted debenzylative sulfonylation of tertiary benzylamines is described. Compared to the traditional S-N coupling reactions, which are promoted by oxidative C-N bond cleavage of sym. tertiary alkylamines, this strategy provides a selective C-N bond cleavage protocol and avoids the use of transition-metal, explosive oxidants, and ligands.

European Journal of Organic Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Safety of 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics