Category: 32345-60-1

Liu, Lei published the artcileSeveral non-salt and solid thienopyridine derivatives as oral P2Y12 receptor inhibitors with good stability, Synthetic Route of 32345-60-1, the main research area is thienopyridine preparation purinoceptor receptor inhibitor; Clopidogrel resistance; Hygroscopicity; P2Y(12) receptor inhibitors; Prodrug design; Stability; Thienopyridine derivatives.

A series of novel thienopyridine derivatives I (R1 = H, Me; R2 = H, Et, Me, 4-mthoxyphenyl, etc.; R3 = H, Me, Ph) was designed and synthesized as P2Y12 receptor inhibitors. Several solid compounds were assessed for inhibitory effect where they exhibited stronger potency than clopidogrel. Compound I (R1 = R3 = H, R2 = Me (II); R1 = R3 = H, R2 = prop-1-en-1-yl) were evaluated for metabolism to verify that they could overcome clopidogrel resistance and for toxicity where they showed lower toxicity than prasugrel. Compound II exhibited lower risk of bleeding than prasugrel and showed good stability under stress testing. Overall, as a promising antiplatelet agent, representative compound II showed the following advantages: (1) no drug resistance for CYP2C19 poor metabolizers; (2) higher potency than clopidogrel; (3) lower toxicity than prasugrel; (4) lower risk of bleeding than prasugrel; and (5) good stability as a non-salt solid.

Bioorganic & Medicinal Chemistry Letters published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 32345-60-1 belongs to class chlorides-buliding-blocks, name is (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, and the molecular formula is C9H9ClO3, Synthetic Route of 32345-60-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ku, Angela F. published the artcileSynthetic Studies of 7-Oxygenated Aporphine Alkaloids: Preparation of (-)-Oliveroline, (-)-Nornuciferidine, and Derivatives, Quality Control of 32345-60-1, the main research area is aporphine alkaloid oxygenated preparation; oliveroline nornuciferidine diastereoselective synthesis; diastereoselective reductive cyclization aporphine alkaloid synthesis; arylation ortho palladium catalyst aporphine alkaloid synthesis.

7-Oxygenated aporphines I (R = Me, R1 = R2 = H, COMe; R2 = CH2, R1 = R2 = H, COMe; R2 = CH2, R1 = Me, R2 = H) and II possessing anti-configurations have previously been reported. In order to explore their bioactivities, a synthesis was established by utilizing a diastereoselective reductive acid-mediated cyclization followed by palladium-catalyzed ortho-arylations. Moderate XPhos precatalyst loading (10 mol %) and short reaction times (30 min) were sufficient to mediate the arylations. Alkaloids I were successfully prepared, while (-)-artabonatine A was revised to syn-isomer III. Consequently, (-)-artabonatine E likely also has a syn-configuration.

Organic Letters published new progress about Aporphine alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 32345-60-1 belongs to class chlorides-buliding-blocks, name is (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, and the molecular formula is C9H9ClO3, Quality Control of 32345-60-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics