Category: 3240-10-06 00:00:00

Yuan, Wen-Kui; Zhu, Ming-Hui; Geng, Rui-Sen; Ren, Guang-Yi; Zhang, Lin-Bao; Wen, Li-Rong; Li, Ming published the artcile< Construction of Benzofuran-3(2H)-one Scaffolds with a Quaternary Center via Rh/Co Relay Catalyzed C-H Functionalization/Annulation of N-Aryloxyacetamides and Propiolic Acids>, Category: chlorides-buliding-blocks, the main research area is benzofuranone preparation rhodium cobalt catalyzed annulation aryloxyacetamide propiolic acid.

An unprecedented synthesis of valuable benzofuran-3(2H)-one scaffolds with a quaternary center was developed via Rh/Co relay catalyzed C-H functionalization/annulation of N-aryloxyacetamides with propiolic acids in moderate to good yields. The reaction features the simultaneous construction of the benzofuran motif containing a C2 quaternary center and a C3 carbonyl group. The preliminary mechanism study verified that the O atom of C3 carbonyl group originates from mol. oxygen.

Organic Letters published new progress about Acetamides Role: RCT (Reactant), RACT (Reactant or Reagent) (aryloxy). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Yongjie; Huang, Liangbin; Jiang, Kai; Cao, Xiaohui; Yin, Biaolin published the artcile< LiCl-Mediated and Palladium-Catalyzed Oxidative Cyclization of Furan-Ynes via Dearomatizing Alkoxyalkenylation of Furan>, Name: 3-(4-Chlorophenyl)propiolic acid, the main research area is furylmethylalkynamide alc palladium catalyst regioselective diastereoselective chemoselective spirocyclization; oxaazaspirononenone preparation.

A LiCl-mediated and palladium(II)-catalyzed oxidative cyclization of furan-ynes via dearomatizing alkoxyalkenylation of furan was reported to afford polyfunctionalized spiro-dihydrofurans with diastereospecification and high Z/E selectivity. This protocol was likely to involved chloropalladation of alkynes, subsequent intramol. dearomatizing alkenylation of furan and final O-allylation. The d. functional theory (DFT) calculations demonstrated that the coordination of furan with dissolved Li+ weakens its nucleophilicity and promoted the Heck insertion and dissolved Cl- promoted chloropalladation of alkynes.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Name: 3-(4-Chlorophenyl)propiolic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yu, Ke; Kong, Xianqiang; Yang, Jiajun; Li, Guodong; Xu, Bo; Chen, Qianjin published the artcile< Electrochemical Oxidative Halogenation of N-Aryl Alkynamides for the Synthesis of Spiro[4.5]trienones>, SDS of cas: 3240-10-6, the main research area is aryl alkynamide alkylamide electrochem oxidative halogenation dearomative spirocyclization; spirotrienone preparation.

We developed a green method for the synthesis of spiro[4.5]trienones through an electrochem. oxidative halocyclization with N-aryl alkynamides. This reaction was conducted under metal-catalyst- and exogenous-oxidant-free conditions at room temperature Using readily available LiCl, LiBr, and LiI as the halogen source, a variety of dearomative halo-spirocyclization products were obtained in good to excellent yields with a broad scope and functional group tolerance.

Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, SDS of cas: 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Luo, Jiajun; Zeng, Guohui; Cao, Xiaohui; Yin, Biaolin published the artcile< Visible-Light-Induced [2+2+1] Dearomative Cascade Cyclization of Indole/Furan Alkynes to Synthesize Sulfonyl Polycycles>, Quality Control of 3240-10-6, the main research area is sulfonyl polycycle preparation visible light; indole furan alkyne dearomative cascade cyclization.

Herein, authors report a visible-light-induced [2+2+1] dearomative cascade cyclization of indole/furan alkynes with NaHSO3, providing an array of diverse highly strained sulfonyl polycycles. Compared to authors previous work, this method does not require the use of addnl. sacrificial oxidants and have wider reaction scope. Preliminary mechanistic studies suggest that the indole moiety initiated the reaction, which proceeded via single-electron oxidation pathway. An alkenyl radical formed by intramol. addition capture SO2, and the resulting species is cyclized to furnish the final product. Also, DFT calculations disclosed that the groups on the indole ring or at the side chain probably affect the single electron distribution at the reaction site of IM-RC-I, and the distribution may be a decisive factor of spirocyclization.

Advanced Synthesis & Catalysis published new progress about C-C bond formation. 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Quality Control of 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Dong-Chao; Wu, Pan-Pan; Du, Pei-Yu; Qu, Gui-Rong; Guo, Hai-Ming published the artcile< Highly Diastereoselective Synthesis of Oxindoles Containing Vicinal Quaternary and Tertiary Stereocenters by a Domino Heck/Decarboxylative Alkynylation Sequence>, Recommanded Product: 3-(4-Chlorophenyl)propiolic acid, the main research area is phenylacrylamide phenylpropiolic acid palladium catalyst Heck decarboxylative alkynylation; oxindole diastereoselective preparation; pyrimidinecarboxamide phenylpropiolic acid palladium catalyst Heck decarboxylative alkynylation; pyrimidinyl spirooxindole diastereoselective preparation.

A palladium-catalyzed domino Heck/decarboxylative alkynylation reaction of trisubstituted alkenes or enamines was reported. For two different types of substrates, the current domino reaction employing different solvents and bases led to 3,3-disubstituted oxindoles and hydropyrimidinyl spirooxindoles containing vicinal quaternary and tertiary stereocenters in moderate to good yields, resp. The general applicability of this method was shown by gram-scale syntheses and diverse transformations of the reaction products. The enantioselective version for this domino process was also studied.

Organic Letters published new progress about Acrylamides Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Recommanded Product: 3-(4-Chlorophenyl)propiolic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lu, Lin; Luo, Chenguang; Peng, Hui; Jiang, Huanfeng; Lei, Ming; Yin, Biaolin published the artcile< Access to Polycyclic Sulfonyl Indolines via Fe(II)-Catalyzed or UV-Driven Formal [2 + 2 + 1] Cyclization Reactions of N-((1H-indol-3-yl)methyl)propiolamides with NaHSO3>, Formula: C9H5ClO2, the main research area is sulfonyl indoline iron catalyst UV cyclization indolylmethylpropiolamide sodium sulfite.

A variety of structurally novel polycyclic sulfonyl indolines were synthesized via FeCl2-catalyzed or UV-driven intramol. formal [2 + 2 + 1] dearomatizing cyclization reactions of N-(1H-indol-3-yl)methylpropiolamides with NaHSO3 in an aqueous medium. The reactions involve the formation of one C-C bond and two C-S bonds in a single step.

Organic Letters published new progress about Crystal structure. 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Formula: C9H5ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Wan-Hui; Jia, Lihong; Feng, Xiujuan; Fang, Dingqiao; Guo, Hongyu; Bao, Ming published the artcile< Efficient Carboxylation of Terminal Alkynes with Carbon Dioxide Catalyzed by Ligand-Free Copper Catalyst under Ambient Conditions>, Product Details of C9H5ClO2, the main research area is propiolic acid preparation; terminal alkyne carbon dioxide carboxylation copper catalyst.

The combined use of simple copper salts and quaternary ammonium salts in a low-boiling-point solvent is presented as a new strategy for terminal alkynes RCCH (R = Ph, 2-thienyl, t-Bu, etc.) carboxylation with CO2 under ambient conditions. The ligand-free copper-catalyzed carboxylation was achieved with CuCl, nBu4NOAc, and K2CO3 in MeCN to produce various propiolic acids RCCC(O)OH in high to excellent yields.

Asian Journal of Organic Chemistry published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Product Details of C9H5ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Seo, Eunkyeong; Oh, Jonghoon; Lee, Sunwoo published the artcile< Metal-Free Decarboxylation of Alkynoic Acids for the Synthesis of Terminal Alkynes>, COA of Formula: C9H5ClO2, the main research area is arylpropiolic acid TMEDA promoter decarboxylation; arylacetylene preparation.

Terminal alkynes were readily obtained via decarboxylation reaction of alkynoic acids with N,N,N’,N’-tetramethylethylenediamine (TMEDA) in DMSO at 65°C for 12 h. This method gave good yields and showed high functional group tolerance. In addition, deuterated terminal alkynes were formed in good yields when alkynoic acids were treated with D2O prior to the reaction with TMEDA.

Asian Journal of Organic Chemistry published new progress about Alkynes, aryl Role: SPN (Synthetic Preparation), PREP (Preparation). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, COA of Formula: C9H5ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Jian; Zhang, Xiaoyi; Wen, Bingyan; Li, Yipei; Wu, Jingjing; Wang, Zhipeng; Wu, Ting; Zhao, Rusong; Yang, Shenghong published the artcile< Pre-carbonized nitrogen-rich polytriazines for the controlled growth of silver nanoparticles: catalysts for enhanced CO2 chemical conversion at atmospheric pressure>, Quality Control of 3240-10-6, the main research area is silver polytriazine carboxylation catalyst precarbonization carbon dioxide capture.

High catalytic activity and sufficient durability are two unavoidable key indexes of an efficient heterogeneous catalyst for the direct carboxylation of terminal alkynes with CO2 conversion. Nitrogen-rich covalent triazine frameworks (CTFs) are promising substrates, while random distribution of some residual -NH2 groups brings challenges to the controlled growth of catalytic species. Here, we adopt a pre-carbonization protocol, annealing below the carbonization temperature, to eliminate the random -NH2 groups in CTFs and meanwhile to promote polycondensation degree under the premise of maintaining the pore structure. Benefiting from the improved condensation and orderly N atoms, p-CTF-250, for which CTFs are annealed at 250°C, exhibits improved CO2 adsorption capacity and the ability to control the growth of Ag NPs. Mono-dispersed Ag NPs are generated controllably and entrapped to form Ag@p-CTF-250 catalysts. These Ag@p-CTF-250 catalysts were employed in the direct carboxylation of various terminal alkynes with CO2 under mild conditions (50°C, 1 atm) and showed excellent catalytic activity. In addition, these catalysts have robust recyclability and can be used for at least 5 catalytic runs while retaining yield above 90%. CO2 conversion proceeds well under the synergistic effect between the high CO2 capture capability and the uniform tiny Ag NPs in Ag@p-CTF-250 “”nanoreactors””. The results represent an efficient strategy for controlling the growth of metallic nanoparticles in porous organic polymer substrates containing disordered heteroatoms.

Catalysis Science & Technology published new progress about Adsorption. 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Quality Control of 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Man; Hua, Jiawei; Wang, Hao; Ma, Tao; Liu, Chengkou; He, Wei; Zhu, Ning; Hu, Yujing; Fang, Zheng; Guo, Kai published the artcile< Photomediated Spirocyclization of N-Benzyl Propiolamide with N-Iodosuccinimide for Access to Azaspiro[4.5]deca-6,9-diene-3,8-dione>, SDS of cas: 3240-10-6, the main research area is iodo azaspirodecadiene dione preparation diastereoselective photochem green chem; benzyl propiolamide iodosuccinimide spirocyclization.

A metal- and oxidant-free route for affording azaspiro[4.5]deca-6,9-diene-3,8-diones (Z) and (E) or (Z) or (E)-I (R1 = H, 6-Me, 7-Br, 7-F, etc.; R2 = Me, Ph, (4-fluorophenyl)sulfonyl, etc.; R3 = Et, Ph, 2-thienyl, etc.) via photomediated iodinated spirocyclization of N-(4-methoxybenzyl)propiolamides R4-4-MeOC6H3CH2N(R2)C(O)CCR3 (R4 = H, 2-Me, 3-Br, 3-F, etc.) has been developed. The reaction underwent a radical addition/ipso-cyclization/dearomatization process at room temperature and successfully constructed C-C and C-I bonds. This green and convenient approach could be generally expanded to produce a range of iodinated spirocyclization products I in moderate to good yields.

Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (propiolamides). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, SDS of cas: 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics