Category: 3240-10-6

Kawatsu, Takahiro; Aoyagi, Keiya; Nakajima, Yumiko; Choi, Jun-Chul; Sato, Kazuhiko; Matsumoto, Kazuhiro published the artcile< Catalytic Decarboxylation of Silyl Alkynoates to Alkynylsilanes>, Application In Synthesis of 3240-10-6, the main research area is copper catalyzed decarboxylation silyl alkynoate.

Herein, the authors describe a decarboxylative approach to the preparation of alkynylsilanes. Treatment of a silyl alkynoate in DMF at 80° in the presence of catalytic amounts of CuCl and PCy3 produced the corresponding alkynylsilane in excellent yield. The Cu-catalyzed decarboxylation proceeded smoothly with low catalyst loadings (0.5 mol % of CuCl and 1.0 mol % of PCy3) under mild reaction conditions and is easily scalable to gram quantities.

Organometallics published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent) (silyl alkynoates). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Application In Synthesis of 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Xia; Lu, Yuling; Guan, Zhenhua; Gu, Lianghu; Chen, Chunmei; Zhu, Hucheng; Luo, Zengwei; Zhang, Yonghui published the artcile< Synthesis of Succinimides via Intramolecular Alder-Ene Reaction of 1,6-Enynes>, Reference of 3240-10-6, the main research area is enyne diastereoselective Alder ene metal free green; succinimide stereoselective preparation.

A novel and convenient method has been developed for the facile synthesis of functionalized succinimide derivatives via intramol. Alder-ene reaction of 1,6-enynes. This reaction features mild and metal-free reaction conditions, which offers a green and efficient entry to synthetically important succinimide scaffolds. Preliminary mechanistic studies suggest that a diradical intermediate might be involved in this transformation.

Organic Letters published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Reference of 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wan, Zi-juan; Yuan, Xiao-feng; Luo, Jun published the artcile< Visible light induced 3-position-selective addition of arylpropiolic acids with ethers via C(sp3)-H functionalization>, Application In Synthesis of 3240-10-6, the main research area is arylpropiolic acid ether photochem diastereoselective regioselective addition reaction; aryl acrylic acid preparation.

An intriguing and mild method for visible light induced regioselective addition of arylpropiolic acids by attacking exclusively at the 3-position with cyclic/acyclic ethers was developed. A variety of 3,3-bis-substituted acrylic acids were successfully obtained in moderate to excellent yields. A plausible reaction mechanism involving an energy transfer induced radical addition in the presence of visible light and photocatalyst was proposed.

Organic & Biomolecular Chemistry published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Application In Synthesis of 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sun, Zhong-Hua; Wang, Xin-Yan; Huang, Kun-Lin; He, Ming-Yang; Chen, Sheng-Chun published the artcile< Heterogeneous catalytic carboxylation of terminal alkynes with CO2 over a copper(II)-based metal-organic framework catalyst>, Recommanded Product: 3-(4-Chlorophenyl)propiolic acid, the main research area is heterogeneous catalytic carboxylation terminal alkyne copper metal framework catalyst.

Developing efficient, inexpensive and robust heterogeneous catalysts for CO2 conversion is greatly important. In this study, a new stable copper(II)-based metal-organic framework [Cu(Fbtx)2Br2]n (denoted as CZU-7, CCDC-2165700, Fbtx = 1,4-bis(1,2,4-triazole-1-ylmethyl)-2,3,5,6-tetrafluorobenzene) was synthesized via a facile and fast microwave heating method. CZU-7 exhibits a two-dimensional layer structure with the 44-sql topol. This material was demonstrated to be an efficient heterogeneous catalyst for the direct carboxylation of 1-ethynylbenzene with CO2, and various propiolic acids were synthesized in moderate to good yields under optimized reaction conditions. Moreover, the catalyst could be easily recovered and reused five times without significant loss of catalytic activity.

Catalysis Communications published new progress about Carboxylation. 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Recommanded Product: 3-(4-Chlorophenyl)propiolic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Song, Liangliang; Liu, Chao; Tian, Guilong; Van Meervelt, Luc; Van der Eycken, Johan; Van der Eycken, Erik V. published the artcile< Late-stage diversification of peptidomimetics and oligopeptides via gold-catalyzed post-Ugi cyclization>, COA of Formula: C9H5ClO2, the main research area is peptidomimetic oligopeptide diversification crystal structure; gold catalyzed post Ugi cyclization cyclocondensation cycloisomerization migration.

A chemo- and regioselective gold-catalyzed tandem 6-endo-dig cyclization/enyne cycloisomerization/1,2-migration process for the synthesis of decorated peptidomimetics is developed. Various migrating groups such as aryl, heteroaryl and alkyl are tolerated in this method under mild conditions. This protocol is successfully utilized to modify various oligopeptides, including substrates bearing the drug amantadine, in a rapid and step-economical manner through the combination with the Ugi reaction.

Molecular Catalysis published new progress about Crystal structure. 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, COA of Formula: C9H5ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Suri Babu, Undamatla; Singam, Maneesh Kumar Reddy; Kumar, Muniganti Naveen; Nanubolu, Jagadeesh Babu; Sridhar Reddy, Maddi published the artcile< Palladium-Catalyzed Carbo-Aminative Cyclization of 1,6-Enynes: Access to Naphthyridinone Derivatives>, Formula: C9H5ClO2, the main research area is naphthyridinone preparation; enyne iodoaniline carbo aminative cyclization palladium catalyst.

A general approach to naphthyridinones I [R = H, 8-Me, 7-F, etc.; Ar = Ph, 4-MeC6H4, Bn, etc.; Ar1 = Ph, 4-MeC6H4, 2-thienyl, etc.] was described via Pd-catalyzed annulation of 1,6-enynes with 2-iodoanilines. This protocol represents a rare carbo-aminative annulative cyclization via 6-endo-trig mode, subduing the well documented exo-trig/dig cyclizations. Regioselective aryl palladation of alkyne followed by Heck type intramol. coupling before isomerization were key in realizing this cascade.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Formula: C9H5ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zeng, Miao; Xue, Jing-Wen; Jiang, Hongwu; Li, Kaiwen; Chen, Yunong; Chen, Zhuqi; Yin, Guochuan published the artcile< Decarboxylative Addition of Propiolic Acids with Indoles to Synthesize Bis(indolyl)methane Derivatives with a Pd(II)/LA Catalyst>, Product Details of C9H5ClO2, the main research area is bisindolylmethane preparation; propiolic acid indole decarboxylative addition palladium Lewis catalyst.

The present work introduces a Pd(II)/LA-catalyzed (LA: Lewis acid) decarboxylative addition reaction for the synthesis of bis(indolyl)methane derivatives The presence of Lewis acid such as Sc(OTf)3 triggered Pd(II)-catalyzed decarboxylative addition of propiolic acids with indoles to offer the bis(indolyl)methane derivatives in moderate to good yields, whereas neither Pd(II) nor Lewis acid alone was active for this synthesis. The catalytic efficiency of Pd(OAc)2 was highly dependent on the Lewis acidity of the added Lewis acid, i.e., a stronger Lewis acid provided a higher yield of the bis(indolyl)methane derivatives Meanwhile, this Pd(II)/LA-catalyzed decarboxylative addition reaction showed good tolerance toward versatile electron-rich or -deficient substituents on the indole skeleton and on the benzyl ring of propiolic acids. The studies on the in situ 1H NMR kinetics of this Pd(II)/Sc(III) catalysis disclosed the formation of a transient vinyl-Pd(II)/Sc(III) intermediate generated by the pyrrole addition to the alkynyl-Pd(II)/Sc(III) species after decarboxylation, which was scarcely observed before.

Journal of Organic Chemistry published new progress about Addition reaction (decarboxylative). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Product Details of C9H5ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Verma, Astha; Grams, R. Justin; Rastatter, Brett P.; Santos, Webster L. published the artcile< Semireduction of alkynoic acids via a transition metal-free α borylation-protodeborylation sequence>, Recommanded Product: 3-(4-Chlorophenyl)propiolic acid, the main research area is acrylic acid preparation; alkynoic acid semiredn diastereoselective.

A method for the semi-reduction of alkynoic acids through an α-borylation and subsequent protodeborylation mechanism was developed. The transition metal-free protocol is achieved through the activation of bis(pinacolato)diboron by an in-situ generated carboxylate moiety yielding aryl acrylic acids. Our studies demonstrate an unprecedented dual role for the carboxylate anion that involves the activation of the diboron reagent and a directing effect in the α-borylation.

Tetrahedron published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Recommanded Product: 3-(4-Chlorophenyl)propiolic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics